Remediation of Cognitive Dysfunction in Euthymic Bipolar Disorder Patients Using Transcranial Direct Current Stimulation (tDCS)

Inclusion Criteria:

• Participants will be right-handed subjects aged 18-65 meeting DSM-IV diagnostic criteria for bipolar disorder, with no acute episodes of depression or mania within the previous 12 weeks
• A score of ≤ 20 on the MADRS, and a score of ≤ 6 on the YMRS, who have been on a stable dose of mood stabiliser medications for at least 1 month.

Exclusion Criteria:

• Patients with high suicide risk
• Co-morbid DSM-IV diagnosis of any psychotic disorder (current or within the last year), schizophrenia and schizoaffective disorder
• Mental retardation
• A history of drug or alcohol abuse or dependence within the last 3 months
• Co-morbid attention deficit hyperactivity disorder (ADHD), or any neurological disorder
• Recent stroke
• Head injury
• History of seizure, or who have had electroconvulsive therapy (ECT) within the 6 months preceding enrolment.
• Participants will also be excluded if currently taking medications known to be associated with frank cognitive impairment (e.g., benzodiazepines).