APOL1 Gene Variants in African American Kidney Transplant Recipients
Impact of APOL1 Gene Variants in African American Kidney Transplant Recipients: A Study of Clinical Outcomes and Molecular Mechanisms
Aim 1:
Determine if there is an association between the APOL1 risk variants and allograft survival and function in African Americans
Aim 2:
Determine if there is an association between the presence of APOL1 risk variants in an African American kidney transplant recipient and the risk of recurrent disease
Aim 3:
Investigate mechanisms of APOL1 associated kidney disease by prospectively following African American kidney transplant recipients throughout their clinical course.
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
Massachusetts
-
Boston、Massachusetts、美国、02115
- Brigham and Women's Hospital
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Aim 1:
Inclusion Criteria:
- self-reported African American
- 18 years or older
- kidney transplant within 12 years
Aim 2:
Inclusion Criteria for patients with recurrent disease:
- self-reported African American
- 18 years or older
- kidney transplant within 12 years
- recurrent or de novo glomerular disease on allograft kidney biopsy
Inclusion Criteria for control group:
- self-reported African American
- 18 years or older
- kidney transplant within 12 years
- end stage kidney disease due to glomerular nephritis, clinically diagnosed or by native kidney biopsy
Exclusion Criteria for control group:
- clinical evidence of recurrent disease (presence of proteinuria, hematuria, Creatinine >2)
Aim 3:
Inclusion Criteria:
- self-reported African American
- 18 years or older
- scheduled living kidney transplant
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
|
2 APOL1 genotypes
African American transplant recipients with homozygous APOL1 gene variants
|
|
0 or 1 APOL1 genotypes
African American transplant recipients without homozygous APOL1 gene variants
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Allograft survival
大体时间：year 1, 3, 5
|
year 1, 3, 5
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Allograft function as measured by serum creatinine
大体时间：creatinine levels at year-1, year-3 and year-5
|
creatinine levels at year-1, year-3 and year-5
|
合作者和调查者
调查人员
- 首席研究员：Anil K Chandraker, MD、Brigham and Women's Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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