Pediatric Optimization of the PharmaJet Needle-Free Intradermal Delivery System (PharmaJet)

Inclusion Criteria:

• Infants and children between ages 2 months and 14 years
• Outpatient, expected to go home day of surgery
• Written consent and assent when appropriate
• Willing to complete and return pain diary (postcard) after 48 hours

Exclusion Criteria:

• Presently have skin rash at the intended injection site
• Have a history of use of any topical or systemic medications at the intended injection site that could have potentially altered the normal physical properties of the skin (i.e. atrophy from chronic steroid use, thinning of the skin from topical or systemic retinoids).
• Have a permanent physical change in the skin at the intended injection site, such as burns, scars or prior radiation therapy.
• Skin disorders that may predispose them to develop skin lesions at sites of trauma.
• Present use of any blood thinning medications.
• In the 10-11 year old cohort, none of the participants can have started puberty.