The Effect of Combined Thermal and Electrical Muscle Stimulation (cTEMS) on Obesity
The Effect of Combined Thermal and Electrical Muscle Stimulation (cTEMS) on Cardiorespiratory Fitness and Adipose Tissue in Obese Individuals
Objective:
It is unclear whether prolonged electrical muscle stimulation can improve cardiorespiratory fitness and reduce body fat in obese subjects. The purpose of this study is to investigate the effect of prolonged combined thermal and electrical muscle stimulation (cTEMS) on peak oxygen consumption (VO2 peak) and body composition. We will also investigate the biochemical effects and the resultant lipolysis-related gene expression changes in adipocytes.
Methods:Eleven obese (BMI≥30) individuals will receive cTEMS in three 60-minute sessions per week for 8 weeks. Activity levels and dietary habits will be kept unchanged and controlled with an accelerometer and nutritional questionnaire. Before and after the stimulation period, functional capacity are assessed by VO2 peak, and body composition was assessed by dual-energy X-ray absorptiometry and bioelectrical impedance analyses. Lipolytic activity will be determined in abdominal adipose tissue by 24 hours of microdialysis on a sedentary day, and adipose tissue biopsies will be taken for the gene expression analysis.
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
-
-
-
Bergen、挪威、5009
- Haukeland University Hospital
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Obese (Body mass index; BMI ≥ 30 kg/m2),
- sedentary subjects (< 20 minutes of exercise < 3 days per week).
- Other inclusion criteria were age between 30 and 70 years and
- the ability to undergo exercise testing.
Exclusion Criteria:
- Pacemaker or implanted defibrillator,
- regular medication,
- cardiovascular disease,
- pulmonary disease,
- extensive dermatological disease or other primary diseases;
- pregnant women;
- and individuals who abuse alcohol or drugs were excluded from the study
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Active
cTEMS
|
cTEMS in three 60-minute sessions per week for 8 weeks
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Oxygen uptake
大体时间：Baseline and after 10 weeks
|
Baseline and after 10 weeks
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Lipolytic activity
大体时间：Baseline and after 10 weeks
|
Lipolytic activity in adipose tissue measured by microdialysis
|
Baseline and after 10 weeks
|
|
Gene expression in adipose tissue
大体时间：Baseline and after 10 weeks
|
Baseline and after 10 weeks
|
|
|
Body composition
大体时间：Baseline and after 10 weeks
|
Body composition by DEXA
|
Baseline and after 10 weeks
|
合作者和调查者
调查人员
- 学习椅：Jan Erik Nordrehaug, PhD、University of Bergen
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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