Tissue and Plasma Biomarkers of Lymph Node Involvement in Cervical Cancer
研究概览
详细说明
SPECIFIC STUDY AIMS
Specific Aim 1: To use gene expression analysis of primary cervical cancers to identify a gene expression signature that predicts for lymph node metastases in this disease.
Specific Aim 2: To predict lymph node metastases by performing multiplex measurements of cancer-associated proteins and cytokines using proximity ligation assay (PLA) on plasma samples.
Specific Aim 3: To measure circulating human papilloma virus (HPV) DNA in the plasma samples of cervical cancer patients using real-time quantitative polymerase chain reaction (qPCR) and determine its ability to predict for nodal metastases.
Specific Aim 4: To use deep sequencing to evaluate gene and sequence differences between cervical cancer patients with and without lymph node metastasis.
研究类型
注册 (实际的)
联系人和位置
学习地点
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California
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Stanford、California、美国、94305
- Stanford University, School of Medicine
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients must have a known or suspected cervical cancer.
- Age >=18 years.
- Patients must have no other active cancer at the time of diagnosis.
- Patients must have no history of a hysterectomy.
- Patients must be able to give informed consent.
- Patients must be willing to undergo a biopsy of the cervical tumor to provide tissue for the study.
- Patients must have completed a standard-of-care FDG-PET/CT prior to initiation of therapy, for assessment of lymph nodes.
Exclusion Criteria:
- Pregnant women
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
验证
|
phlebotomy
|
|
Testing
|
phlebotomy
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Biomarkers (genes and proteins) of lymph node involvement
大体时间：4 years
|
4 years
|
合作者和调查者
调查人员
- 首席研究员：Elizabeth Kidd, MD、Stanford University
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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