The Effect of Eating Frequency on Blood Pressure
The Effect of Number of Eating Episodes Per Day on Blood Pressure. A Randomised Controlled Trial
研究概览
详细说明
Migration studies, observational epidemiology and clinical trial data indicate that causes of adverse BP levels are mainly environmental , including lifestyle under which dietary factors play a role. Therefore, lifestyle modification is part of the current American Heart Association recommendations for prevention and control of adverse BP levels.
Although the effects of nutrients and foods on BP have been studied extensively, other dietetic factors such as eating frequency and number of meals in a day have been less thoroughly investigated and warrant further research to explore their possible positive effect on BP.
研究类型
阶段
- 不适用
联系人和位置
学习地点
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London、英国、w2
- Sir John Michael Center - Hammersmith Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
Healthy individuals aged 35-70 years with prehypertension (systolic/diastolic BP 120-139/80-89 mm Hg) BMI 20-30 kg/m2 non-smoking non alcoholic drinkers
Exclusion Criteria:
- Weight change of ≥ 3kg in the preceding 2 months
- Current smokers
- Substance abuse
- Alcohol intake
- Pregnancy
- Diabetes
- Cardiovascular disease
- Cancer
- Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
- Kidney disease
- Liver disease
- Pancreatitis
- Use of medications including: anti inflammatory drugs or steroids, antihypertensive drugs, cholesterol lowering medication, androgens, phenytoin, erythromycin or thyroid hormones.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：low frequency diet
Participants will be assigned to a low frequency diet (fixed energy intake)
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a low frequency diet (3 meals/day) a high frequency diet (9 meals/day)
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实验性的：High frequency diet
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a low frequency diet (3 meals/day) a high frequency diet (9 meals/day)
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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blood pressure
大体时间：2 weeks for 24 hours through blood pressure monitor
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Participants will be asked to wear BP monitor continuously for one week then return it back either by post or bring it themselves to the center.
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2 weeks for 24 hours through blood pressure monitor
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Insulin
大体时间：measured twice during each phase (2 phases)
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biomarkers like: Insulin - Glucose- lipid profile- Free fatty acids- C peptides- HS CRP will be measured regularly during study
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measured twice during each phase (2 phases)
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (预期的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- CRO197
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研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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