Quantitative 18F-AV-133 PET Imaging in Subjects With Diabetes and Healthy Controls

Inclusion Criteria:

• Male and/or female subjects of non-childbearing potential between the ages of 30 and 65 years inclusive.
• Able to tolerate PET, PET/CT and MR imaging
• Estimated creatinine clearance >= 60mL/min
• Informed consent documents signed and dated by subject
• Subjects must be willing and able to comply with all scheduled visits, treatments laboratory tests, scans and other study procedures.

• In addition, subjects must meet classification requirements for one of the following

  1. Healthy Overweight
  2. Pre-diabetes
  3. T2DM
• (T2DM only) Subjects with other chronic medical conditions (besides diabetes) that are well controlled and stable on medication are acceptable for inclusion in this study.

Exclusion Criteria:

• Subjects who are affiliated with or relatives of staff members of either the site or Pfizer directly involved in the conduct of the trial.
• Conditions which in the opinion of the study investigator may interfere with the subject's ability to participate in the study
• History of allergic reaction to drug/contrast agent or history of drug/alcohol abuse
• Subjects who have received investigational medications within the last 30 days or a radiopharmaceutical in the past 7 days.
• Pregnant or nursing females; females of childbearing potential.