Study on Single-nucleotide-polymorphism in Idiopathic Membranous Nephropathy
Mechanism Research of Traditional Chinese Medicine (the Comprehensive Treatment Regimen) in Treating Idiopathic Membranous Nephropathy by Genomewide Association Studies
研究概览
地位
条件
详细说明
研究类型
注册 (预期的)
联系人和位置
学习地点
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Shanghai
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Shanghai、Shanghai、中国、200032
- 招聘中
- Shanghai University of Traditional Chinese Medicine
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接触：
- Wang Lin, PHD
- 电话号码：86-13816583673
- 邮箱：happytlynn@163.com
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Clinical diagnosis of idiopathic membranous nephropathy
- Chronic Kidney Disease (CKD)≤3 stage（Glomerular Filtration Rate (GFR)≥30ml/min）and 24 hour urinary protein≥3g
- Voluntarily participated in the study and signed an informed consent
Exclusion Criteria:
- Combined life-threatening complications such as serious infection
- Abnormal glucose metabolism
- Patients with malignant tumors or malignancy , HIV infection and a history of mental illness , acute central nervous system disease , serious gastrointestinal diseases,etc
- Pregnancy or breast-feeding women
- Undergoing other clinical trials
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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CR/CTR group
The complete remission group treated by the Comprehensive Treatment Regimen
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①ShenQiMoShen Decoction: which plays vital therapeutic effect in the CTR,the dosage is 150ml per serving and two services per day.Dosage and administration:150ml per time,twice per day ②HuoXueTongMai Capsule : which plays a vital role of promoting blood circulation and removing blood stasis. Its main components are the leeches. Dosage and administration: 4 capsules 3 times daily. ③HeiLiaoDou Particle: which will be prescribed when hypoproteinemia (serum albumin concentration≤30g/L)occurred and should be stopped taking until the serum albumin is above 30g/L. Dosage and administration: 2 packages 3 times daily.
其他名称：
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NR/CTR group
The non-remission group treated by the Comprehensive Treatment Regimen
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①ShenQiMoShen Decoction: which plays vital therapeutic effect in the CTR,the dosage is 150ml per serving and two services per day.Dosage and administration:150ml per time,twice per day ②HuoXueTongMai Capsule : which plays a vital role of promoting blood circulation and removing blood stasis. Its main components are the leeches. Dosage and administration: 4 capsules 3 times daily. ③HeiLiaoDou Particle: which will be prescribed when hypoproteinemia (serum albumin concentration≤30g/L)occurred and should be stopped taking until the serum albumin is above 30g/L. Dosage and administration: 2 packages 3 times daily.
其他名称：
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CR/IA group
The complete remission group treated by Immunosuppressive Agents
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According to Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guideline for glomerulonephritis
其他名称：
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NR/IA group
The non-remission group treated by Immunosuppressive Agents.
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According to Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guideline for glomerulonephritis
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Genome-wide single-nucleotide-polymorphism of IMN patients treated by the Comprehensive Treatment Regimen or conventional approach
大体时间：one year
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Screening for single-nucleotide-polymorphism as the prognostic factor for the TCM intervention of IMN patients.
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one year
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合作者和调查者
调查人员
- 研究主任：Wang Lin, PHD,MD、Shanghai University of Traditional Chinese Medicine
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- ShanghaiMEC-2011
- 11YZ65 (其他赠款/资助编号：Shanghai Municipal Education Commission)
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