miRNA in Fetal Overgrowth (MIFO)
Placental miRNA (microRNA) Profile in Fetal Overgrowth Related to Maternal Obesity Study
研究概览
详细说明
MicroRNA's are a class of non-coding RNA's that function as translational repressors and are thought to modulate tissue development, proliferation, differentiation and function. Differential expression of certain placental miRNA's has been associated with preeclampsia.
The fetal origins of adult disease hypothesis suggests that risk factors from intrauterine environmental exposures affect the fetus' development during sensitive periods, and increases the risk of specific diseases in adult life. Our aim is to understand factors that predispose fetuses to fetal overgrowth in utero, especially in women with obesity. The objective of the study is to identify miRNA which are differentially expressed in the placenta and cord blood of pregnancies that are affected by fetal macrosomia to determine factors that may predispose fetuses to fetal overgrowth.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Pennsylvania
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Philadelphia、Pennsylvania、美国、19104
- Hospital of the University of Pennsylvania
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- singleton pregnancy
- prenatal care & delivery at the Hospital of the University of Pennsylvania system
- Normal glucose tolerance test results (less than 120 mg/dl)
Exclusion Criteria:
- Multiple gestation
- under 18 years old, or over 45 years old
- chronic hypertension
- preeclampsia
- chronic steroid use
- diabetes
- major fetal anomaly
- connective tissue disorder requiring medication
- active HIV
- Hepatitis C
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Obese mother/ Macrosomic baby
Obese mother that delivers a macrosomic neonate to understand the effects neonatal exposure to maternal obesity.
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Obese mother/ normal weight baby
Obese mother that delivers a normal weight neonate to understand effects neonatal exposure to maternal obesity.
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Normal weight mother/ Macrosomic baby
Normal weight mother that delivers a macrosomic neonate
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Normal weight mother/ Normal weight baby
Normal weight mother who delivered a normal weight neonate
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Fetal Overgrowth
大体时间：Delivery date to up to 6 weeks post partum
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Placental and cord blood samples will be studied for miRNA expression.
The objective of the study is to identify miRNA which are differentially expressed in the placenta and cord blood of pregnancies that are affected by fetal macrosomia to determine factors that may predispose fetuses to fetal overgrowth.
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Delivery date to up to 6 weeks post partum
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合作者和调查者
调查人员
- 首席研究员：Celeste P Durnwald, MD、University of Pennsylvania
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
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