Unexpected Pharmacokinetics of Vancomycin in Patients With Severe Acute Pancreatitis Compared With Pneumonia
研究概览
地位
详细说明
The purpose of this study was to evaluate the influence of severe acute pancreatitis on the serum level of vancomycin, a glycopeptide antibacterial agent.
After reviewing more than 6000 clinical charts of patients who received vancomycin therapy and whose serum vancomycin level was monitored between January 2010 and December 2013, we identified 212 patients who also had diagnosed as severe acute pancreatitis (SAP group), and 98 patients who also had diagnosed as pneumonia (pneumonia group) at that time. The fluorescence polarization immunoassay method was used to measure vancomycin serum trough concentrations in these patients 30 min before the next administration. Using these measurements, we calculated the pharmacokinetic parameters using the Bayesian estimator.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Shanghai
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Shanghai、Shanghai、中国、200025
- 招聘中
- Ruijin Hospital
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接触：
- He
- 电话号码：662618 86-21-64370045
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- age 18-85years old
- vancomycin use ≥ 3days
Exclusion Criteria:
- age <18years old or >85 years old
- vancomycin use < 3days
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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severe acute pancreatitis
patients who received vancomycin therapy and whose serum vancomycin level was monitored, and who also had diagnosed as severe acute pancreatitis.
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Pneumonia
patients who received vancomycin therapy and whose serum vancomycin level was monitored, and who also had diagnosed as pneumonia.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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vancomycin serum trough concentrations in these patients just prior to the next vancomycin serum trough concentrations was measured
大体时间：patients will be followed for the duration of hospital stay, an expected average of 5 weeks
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vancomycin serum trough concentrations was measured in patients just prior to the next dose at steady-state conditions (approximately after the fourth dose).
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patients will be followed for the duration of hospital stay, an expected average of 5 weeks
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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the pharmacokinetic parameters was calculated using the Bayesian estimator.
大体时间：patients will be followed for the duration of hospital stay, an expected average of 5 weeks
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patients will be followed for the duration of hospital stay, an expected average of 5 weeks
|
合作者和调查者
调查人员
- 研究主任：Wan-Hua Yang, Prof.、Ruijin Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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