Timing for Arteriovenous Fistula Creation and Its Effect on Target Organs in Patients With Chronic Renal Failure (TACTIC)

Inclusion Criteria:

• Patients with chronic renal failure, without AVF creation;
• Estimated glomerular filtration rate (eGFR) <15ml/min 1.73m2 for patients without diabetic kidney disease, and eGFR<20ml/min 1.73m2 for diabetic kidney disease;
• All study subjects must agree to participate in the study and provide written informed consent.

Exclusion Criteria:

• Patients with the history of arteriovenous graft, or central venous catheter, or peritoneal dialysis catheter placement;

• Contraindications to AVF construction:

  • Allen's Test is positive, or arterial diameter<2 mm; venous diameter<2.5 mm or venous occlusion/stenosis.
  • Local infection.
• Have any other uncontrolled medical condition (severe heart failure, malignancy, severe coagulation disorders ).
• Mental illness that makes the patients unable to complete the trial.
• Female who is planning to become pregnant, who is pregnant and/or lactating, who is unwilling to use effective means of contraception.