Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS (ITEMS)
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease. Various studies have shown that there was a breach of episodic memory, working memory, attention and executive functions regardless of the form of disease, disability or duration of disease progression.
The main objective of this study is to investigate the influence of emotional components and executive processes on the components retrograde and anterograde episodic memory (thanks to an original paradigm based on the emotional valence of the memory) in MS patients
研究概览
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Basse-Normandie
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Caen、Basse-Normandie、法国、14033
- 招聘中
- Department of Neurologie, Caen Hospital University
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接触：
- Gilles Defer, Professor
- 电话号码：+33231064620
- 邮箱：defer.gi@chu-caen.fr
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Men and women 30-60 years of age
- Definite MS (McDonald criteria revised in 2005)
- EDSS <6
- Sick Shapes: Relapsing multiple sclerosis, Primary progressive multiple sclerosis
- All durations evolution
- French Mother tongue
- Signature of informed consent
Exclusion Criteria:
- Other neurological conditions, previous psychiatric or developmental diagnosis of MS
- Head injury sequelae
- Chronic alcohol or drugs Taking
- EDSS greater than or equal to 6
- Secondary Progressive Form
- Push and / or treatment with corticosteroids within one month
- Treatments Amantadine, Modafinil introduced for less than 3 months
- Patient Trust
- Cognitive Assessment of less than one year (including in particular all or part of the balance sheet proposed in this project)
- Any visual motor deficit or incompatible with the award of cognitive tests
- For women, pregnancy, breastfeeding and / or lack of contraception (a pregnancy test will be done before the PET scan)
- Patient with indications against MRI
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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其他：Neuropsychological tests
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Neuropsychological tests
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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anterograde episodic memory: 3 scores of emotional ESR
大体时间：baseline
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3 scores of emotional ESR
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baseline
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retrograde episodic memory: 9 scores TEMP emotional
大体时间：baseline
|
9 scores TEMP emotional
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baseline
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- 09-016
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