Elimination of Antibiotics During Citrate-anticoagulated Continuous-veno-venous-haemodialysis (DIADSORBMAB)
Acute kidney injury (AKI) requiring renal replacement therapy is common in critically ill patients. The major causes of AKI are severe sepsis and septic shock requiring effective antibiotic treatment. Patients with sepsis on ICUs usually are haemodynamically instable so that renal replacement therapy is applied using continuous techniques. In recent years, the efficacy of renal replacement therapies has improved, namely by using regional citrate anticoagulation which improves filter lifetime and filter patency. At present, the extent of removal of antibiotic drugs using citrate-anticoagulated CVVHD in critically ill patients has not been investigated thoroughly. Thus, the investigators want to investigate
- whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during citrate-anticoagulated CVVHD per se
- whether filter patency during citrate-anticoagulated CVVD remains stable during a treatment period of 72 h
研究概览
研究类型
注册 (预期的)
联系人和位置
学习地点
-
-
-
Duesseldorf、德国、40225
- Prof. Kindgen-Milles
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Intensive care patients with acute kidney injury requiring continous renal replacement therapy with citrate-anticoagulation
- Age > 18 y
Exclusion Criteria:
- < 18 y
- Pregnancy
- Contraindications against citrate-anticoagulation or continous renal replacement therapy
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
|---|
|
Piperacillin/Tazobactam
Patients undergoing continuous veno-venous renal replacement therapy and treated with this antibiotics
|
|
Imipenem/Cilastatin
Patients undergoing continuous veno-venous renal replacement therapy and treated with this antibiotics
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Removal of antibiotic drugs during day 1 - 2 - 3 of citrate anticoagulated CVVHD (mg/d)
大体时间：up to three days
|
Total hemofilter clearance (ml/min) of imipenem/cilastatin and piperacillin/tazobactam on each treatment day during an 8-hour dosing interval using blood sided clearance - Total amount of antibiotic drug which is eliminated via the filter during 24 h using filter clearance and delivered dialysis dose during 24 h |
up to three days
|
|
Filter patency during day 1 - 2 - 3 of citrate anticoagulated CVVHD
大体时间：up to three days
|
Filter patency is calculated as a function of the sieving coefficient for small solutes (i.e.
creatinine and the respective antibiotic drugs) over the first 72 h, Sieving coefficient is without dimension
|
up to three days
|
合作者和调查者
调查人员
- 研究主任：Detlef Kindgen-Milles, Prof.、Department of Anesthesiology
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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