Clinical Outcomes in Elderly Patients With Preoperative Cognitive Dysfunction
2017年5月3日 更新者：Jian-jun Yang、Zhongda Hospital
Cognitive Trajectories and Clinical Outcomes in Elderly Patients With Preoperative Cognitive Dysfunction
Preexisting cognitive impairment, such as mild cognitive impairment, is common in many elderly patients who undergoing major surgeries.
Accumulating evidence has demonstrated that preexisting cognitive impairment is associated with increased mortality, increased incidence of postoperative complications, decreased quality of life, and worse outcomes.
However, few studies have evaluated the relationship between preexisting cognitive impairment and cognitive trajectories and clinical outcomes.
研究概览
详细说明
Preexisting cognitive impairment is common in many elderly patients who undergoing major surgeries.
The number of surgical procedures in the elderly will increase dramatically as a result of the increased elderly population in the future.
It has been suggested that preexisting cognitive impairment is associated with increased incidence of postoperative complications, decreased quality of life, and increased mortality.
Preoperative risk assessment is becoming increasingly important because preoperative risk stratification allows the clinical team to forecast postoperative outcomes.
Currently, the most common strategy to identify high-risk patients before surgery is assessment of single end-organ function.
This tactic is most widely recognized by the American Heart Association's guideline for cardiac evaluation, but is also well described for pulmonary, hepatic, and renal organ systems.
Little is known about the effects of pre-existing cognitive (or brain) function (perhaps the most vital human organ) on postoperative outcomes.
Therefore, the present study evaluated whether patients with pre-operative cognitive impairment would have a more precipitous drop in cognitive function and worse outcome in geriatric surgical patients.
研究类型
观察性的
注册 (预期的)
500
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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Jiangsu
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Nanjing、Jiangsu、中国、210009
- 招聘中
- Zhongda Hospital
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接触：
- Jian-jun Yang, Dr
- 电话号码：13357739238
- 邮箱：yjyangjj@126.com
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
65年 及以上 (年长者)
接受健康志愿者
不
有资格学习的性别
全部
取样方法
概率样本
研究人群
Patients were 65 years and older undergoing an elective operation on the general, noncardiac thoracic, urologic, and vascular surgical services.
描述
Inclusion Criteria:
- Inclusion criteria were persons 65 years and older undergoing an elective operation on the general, noncardiac thoracic, urologic, and vascular surgical services.
Exclusion Criteria:
- Patients with vision or hearing impairment who could not visualize pictures or hear instructions associated with the delirium assessments and patients who could not provide informed consent.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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Control group
Patients in this group have normal cognition as assessed by the validated Mini-Cog test before the elective operation.
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Impaired group
Patients in this group have impaired cognition as assessed by the validated Mini-Cog test before the elective operation.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Cognition changes
大体时间：1 year
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Cognitive function was assessed at baseline before the elective operation and one year in all subjects using the Mini-Cog test by a member of a trained research team.
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1 year
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2016年7月1日
初级完成 (预期的)
2018年5月1日
研究完成 (预期的)
2018年8月1日
研究注册日期
首次提交
2017年4月26日
首先提交符合 QC 标准的
2017年5月3日
首次发布 (实际的)
2017年5月8日
研究记录更新
最后更新发布 (实际的)
2017年5月8日
上次提交的符合 QC 标准的更新
2017年5月3日
最后验证
2016年5月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.