Age Dependency of Biological Reaction on Wear Particles
Wear is the main reason for revision operations after joint arthroplasty. While the survival of modern implants is often longer than the expected life span in old patients, young patients (<60 years) have to expect at least one wear induced revision operation. The reason is the throughout all registries consistantly significantly reduced implant survival rates in young patients. In the swedish arthrplasty registry the 15 year survival for patients older than 75 years is 95 % and for those younger than 50 years is 75 %. This corresponds to a 5fold increased revision rate (5 % vs. 25 %) 15 years after implantation. This significant difference cannot be explained by the higher activity of younger patients alone. Patient specific factors, that modulate the biological reaction on wear particles, are therefore highly probable. These could explain the significant age dependency of implant survival.
The main hypothesis of this study is therefore, that the biological reaction on wear particles depends on the patients age.
研究概览
研究类型
注册 (预期的)
联系人和位置
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- having received a total hip arthroplasty 4 weeks before blood sample for this study
Exclusion Criteria:
- no informed consent
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
---|---|
<40
patients younger than 40 years
|
standardized wear particles are co-incubated with isolated patient cells (monocytes)
|
40-60
patients younger than 60 years and not older than 40 years
|
standardized wear particles are co-incubated with isolated patient cells (monocytes)
|
60-80
patients younger than 80 years and not older than 80 years
|
standardized wear particles are co-incubated with isolated patient cells (monocytes)
|
>80
patients older than 80 years
|
standardized wear particles are co-incubated with isolated patient cells (monocytes)
|
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
biological reaction
大体时间:one hour
|
TNF-alpha concentration one hour after incubation of patient cells with wear particles in-vitro
|
one hour
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (预期的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- AgeWear
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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