Red Meat, Increased Iron Load and CVD Risk
Red Meat Consumption and Risk of Cardiovascular Diseases - is Increased Iron Load a Possible Link?
研究概览
详细说明
The present study part of the the European Prospective Investigation into Cancer and Nutrition (EPIC) - Heidelberg, a large-scale observational cohort study located at the German Cancer Research Center, Heidelberg, Germany. The study started between 1994 and 1998, when 25 540 adults from the local general population were recruited. Study participants are being followed-up by active and passive procedures. The main aim of the study is to evaluate associations between diet, lifestyle as well as metabolism and risks of major chronic diseases (cancer, cardiovascular diseases, diabetes).
Here, the investigators register a project from within EPIC-Heidelberg on prediagnostic iron status as a potential mediator of associations between pre-diagnostic red meat consumption and cardiovascular disease risk. For this particular project, an embedded case-cohort set-up was chosen, i.e. iron status markers (primary marker: serum ferritin; secondary markers: serum transferrin, serum iron) were measured in baseline blood samples from a random subcohort (n=2738) and all validated incident cases of myocardial infarction (n=556), stroke (n=513), and CVD death (n=327) that occured until the closure date of the present study (12-31-2009).
Statistical analyses follow four steps to assess whether iron status may mediate associations between red meat consumption and CVD risk, as proposed by Wittenbecher et al. (Am J Clin Nutr, 2015: www.ncbi.nlm.nih.gov/pubmed/25948672):
- Multivariable Cox regression analyses on red meat consumption and CVD risk, assuming a significant positive association
- Multivariable linear regression analyses on red meat consumption and iron status, assuming a significant positive association
- Multivariable Cox regression analyses on iron status and CVD risk, assuming a significant positive association
- Multivariable Cox regression analyses on red meat consumption and CVD risk, additionally adjusting for iron status, assuming that the association will be attenuated by adjustment for iron status
研究类型
注册 (实际的)
联系人和位置
学习地点
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Heidelberg、德国、69120
- German Cancer Research Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
General population, age 35-65 years
Exclusion Criteria:
Prevalent myocardial infraction or stroke
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
干预/治疗 |
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Random Subcohort
Random subcohort (~10 % of the initial cohort, study has a case-cohort design; details on the case-cohort design have been described by Kulathinal et al., Epidemiol Perspect Innov, 2007: www.ncbi.nlm.nih.gov/pmc/articles/PMC2216006/).
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No intervention assigned, this is an observational study.
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Incident CVD Cases
Validated incident cases of myocardial infarction, stroke and CVD death that occured until Dec-31-2009 (details on the case-cohort design have been described by Kulathinal et al., Epidemiol Perspect Innov, 2007: www.ncbi.nlm.nih.gov/pmc/articles/PMC2216006/).
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No intervention assigned, this is an observational study.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Myocardial infraction
大体时间：1994 - 2009
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Incident cases of primary myocardial infarction according to clinical records
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1994 - 2009
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Stroke
大体时间：1994 - 2009
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Incident cases of primary stroke according to clinical records
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1994 - 2009
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Cardiovascular death
大体时间：1994 - 2009
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Incident cases of cardiovascular death according to death certificates
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1994 - 2009
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合作者和调查者
调查人员
- 首席研究员：Rudolf Kaaks, Prof.、German Cancer Research Center
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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