Effect of Oily Fish Intake, Sex, Age, BMI, and APOE Genotype on Plasma Long Chain n-3 Fatty Acid Composition
研究概览
地位
详细说明
The marine long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are beneficial to cardiovascular and cognitive health and the concentration of EPA and DHA present in blood and tissue lipids is positively correlated with these effects.
As a result, national and global authorities recommend regular consumption of oily fish in order to provide approximately 500 mg EPA+DHA per day in a healthy population. However, the associations between EPA and DHA intake and blood and tissue status, and therefore physiological benefits, are highly variable and the factors influencing this heterogeneity are not well understood.
This study aims to investigate the effect of habitual oily fish intake as well as sex, age, BMI, and Apolipoprotein E (APOE) genotype on LC n-3 PUFA status in plasma phosphatidylcholine, non-esterified fatty acids, cholesteryl esters and triacylglycerols in order to obtain greater knowledge of the determinants of LC n-3 PUFA status with the potential to develop more robust, and perhaps subgroup specific, recommendations for EPA and DHA intake.
研究类型
注册 (实际的)
联系人和位置
学习地点
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-
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Glasgow、英国
- University of Glasgow
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Newcastle upon Tyne、英国
- Newcastle University
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Norwich、英国
- Univeristy of East Anglia
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Reading、英国
- University of Reading
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Southampton、英国
- University of Southampton
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Exclusion Criteria:
- Diagnosed endocrine dysfunction including diabetes
- Fasting glucose concentration > 6.5 mmol/L
- Myocardial infarction in the previous 2 years
- The use of medication that may interfere with lipid metabolism
- Fasting total cholesterol of > 8.0 mmol/L
- TG of > 3.0 mmol/L
- Currently following a weight loss diet
- Taking n-3 fatty acid supplements
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：横截面
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Plasma long chain n-3 polyunsaturated fatty acid concentrations
大体时间：Baseline
|
Concentrations of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) in plasma phosphatidylcholine, non-esterified fatty acids, cholesteryl esters and triacylglycerols
|
Baseline
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
APOE genotyping
大体时间：Baseline
|
APOE genotype determined from blood sample
|
Baseline
|
|
Anthropometric measurements
大体时间：Baseline
|
Height and weight to determine BMI
|
Baseline
|
合作者和调查者
调查人员
- 首席研究员：Philip C Calder、University of Southampton
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- RRD7/N02/A
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
在美国制造并从美国出口的产品
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Plasma Omega-3 Status的临床试验
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RDC Clinical Pty LtdDSM-Firmenich AG招聘中
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Universidad de GranadaFundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental招聘中
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Fatty Acid Research InstituteOmegaquant Analytics, LLC尚未招聘Omega-3 脂肪酸
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St. Mary's University, Twickenham尚未招聘关注Omega-3指数对恢复的影响
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USDA Grand Forks Human Nutrition Research CenterUnited States Department of Agriculture (USDA); University of North Dakota完全的
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Medical University of South CarolinaAker Biomarine Antarctic AS完全的