Long Term Metformin in Women With Polycystic Ovary Syndrome
Effects of Long Term Treatment With Metformin on Clinical, Metabolic and Endocrine Parameters in Women With Polycystic Ovary Syndrome And Increased Metabolic Risk
The investigators analyzed collection data of 10 years for the efficacy of metformin on body mass, menstrual frequencies, metabolic and hormonal outcomes in women with polycystic ovary syndrome (PCOS) and BMI ≥ 25kg/m2.
Each patient's age and height were recorded at baseline. In addition each patient weight, waist circumference, menstrual regularity, fasting glucose, glucose after 120 minute oral glucose tolerance test, luteinizing hormone, follicle stimulating hormone , free and direct testosterone, androstenedione, sex hormone binding globulin, dehydroepiandrosterone sulfate were identified at baseline and at the every follow up visit where available.
研究概览
地位
条件
研究类型
注册 (实际的)
联系人和位置
学习地点
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Ljubljana、斯洛文尼亚、1000
- University Medical Center Ljubljana
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- PCOS phenotype A
- BMI≥ 25kg/m2
- metformin 1000mg twice a day for at least one year
Exclusion Criteria:
- PCOS phenotype B, C, D
- BMI <25kg/m2
- had been treated with spironolactone or oral contraceptives alone or in combination with metformin
- had history of bariatric surgery
- became pregnant during the observation period
- had inability to tolerate metformin, leading to the cessation of drug therapy within first follow up year
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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body weight
大体时间：The measurement is assessed in kilograms at the beginning and after every year of taking metformin for 10 years.
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Primary outcome was change in body weight.
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The measurement is assessed in kilograms at the beginning and after every year of taking metformin for 10 years.
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menstrual frequency
大体时间：The measurement is assessed in number of bleeds per year at the beginning and after every year of taking metformin for 10 years.
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Primary outcome was change in menstrual frequency.
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The measurement is assessed in number of bleeds per year at the beginning and after every year of taking metformin for 10 years.
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free testosterone
大体时间：The measurement is assessed in nmol/L at the beginning and after every year of taking metformin for 10 years.
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Primary outcome was change in levels of free testosterone.
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The measurement is assessed in nmol/L at the beginning and after every year of taking metformin for 10 years.
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diabetes mellitus
大体时间：The measurement of glucose in blood is assessed in mmol/L at the beginning and after every year of taking metformin for 10 years.
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Primary outcome was development of diabetes mellitus.
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The measurement of glucose in blood is assessed in mmol/L at the beginning and after every year of taking metformin for 10 years.
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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