Donor Gender Effect on Graft Function in Adult Egyptian Patients Undergoing Living Donor Liver Transplant

Intraoperatively, Both standard anesthetic and piggyback liver transplant for hepatic transplantation will be performed by the same anesthesia and surgical team . Intraoperative hemodynamics (MAP and HR), graft weight to recipient weight ratio (GWRWR), blood products transfused and intraoperative adverse events will be recorded. At the end of surgery patients will be transferred to the ICU where they will be monitored and will receive the standard protocol for postoperative management after liver transplantation.

- Recipients will be divided into two groups ( matched and mismatched) and will be subdivided based on the following variables: recipient age, MELD score, intraoperative packed red blood cells (PRBC) and fresh frozen plasma (FFP) transfusions, duration of cold ischemia. These subgroups will be compared with respect to 2-year graft survival separately in recipients of sex matched and mismatched transplantation.

Inclusion Criteria:

• Adult Egyptian Patients >18 years.

Exclusion Criteria:

• Patient refusal.
• Patients who underwent re-transplantation before discharge from the ICU after the first liver transplant.
• Intraoperative cardiac arrest or immediately postoperative cardiac arrest within the first 6 hours postoperative.
• Massive blood loss.
• Pre-existing renal failure requiring hemodialysis or continuous hemofiltration.
• Pregnancy.