Metabolic Effects of Morning 16/8 Fasting
Short-term Metabolic Effects of Morning Energy Restriction Versus Two Different Early-day Nutrition Strategies
研究概览
详细说明
The study design meets a cross-over pattern with 3 different morning visits of 6 hour duration each. After an informed consent is received from the participant, a crude medical history, physical examination and collection of somatometric data through bio-impendance analysis will take place. An intravenous catheter will be placed in the participants forearm.
At zero time point, depending on study visit, participants will either (A) remain fasted (B) start consuming ta pre-prepared zero-carbohydrate 500 kcal test meal (C) start consuming ta pre-prepared 500 kcal test meal with a composition conforming to a standard Mediterannean breakfast. Participants will be given 10 minutes to consume the meal.
Blood samples will be drawn and visual analogue scales (VAS) for hunger and satiety will be filled in at the following time points (min): -15, 0, 15, 30, 60, 90, 120, 180, 240, 300, 360.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Athens、希腊、11527
- Diabetes Clinical Research Laboratory, 1st Department of Propaedeutic Internal Medicine
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- BMI 18-25 kg/m2
- Willfulness to participate
Exclusion Criteria:
- Overweight or obesity (BMI>25 kg/m2)
- Type 1 or 2 diabetes mellitus
- Uncontrolled thyroid disorders
学习计划
研究是如何设计的？
设计细节
- 主要用途：其他
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Fasting
6-hour morning fasting
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6-hour fasting
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实验性的：Low carbohydrate
Consumption of a zero-carbohydrate breakfast
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Consumption of a zero-carbohydrate breakfast
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实验性的：Mediterranean
Consumption of a Mediterranean breakfast
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Consumption of a Mediterranean-type breakfast
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Mobilisation of adipose tissue
大体时间：6 hours
|
Area Under the Curve (AUC) of free fatty acid (FFA) and beta-Hydroxybutyrate (bOB) concentration
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6 hours
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Mobilisation of gut peptides
大体时间：6 hours
|
AUC of Ghrelin, Peptide YY and glucagon-like peptide -1 (GLP-1) concentration
|
6 hours
|
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Degree of appetite suppression
大体时间：6 hours
|
Visual Analogue Scale score (0-10, 0 equals minimal and 10 equals highest) for appetite
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6 hours
|
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Degree of satiety induction
大体时间：6 hours
|
Visual Analogue Scale score (0-10, 0 equals minimal and 10 equals highest) for satiety
|
6 hours
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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