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评估人群慢性病构成中流动性受损 (EVALMOB)

2026年11月2日 更新者：University Hospital, Clermont-Ferrand

Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge both for the treatment of causal pathologies, as well as for evaluating the impact of therapeutic interventions, the benefit of which will be an improvement in physical capacities and ultimately mobility. In view of the hypothesis of an increase in the prevalence of mobility disorders in this population, this approach is part of a logic of screening and improving the effectiveness of the care of these patients with a multidisciplinary evaluation of individual risks. The EVALMOB protocol was designed in order to try to determine a standard profile of "dysmobility" in patients with chronic illness

研究概览

地位

招聘中

条件

干预/治疗

详细说明

We propose to constitute a prospective cohort of subjects carrying chronic disease. The objective is to explore all the different components of mobility (balance, muscle force, body composition, walking ability, metabolism, etc.), to assess their impact on the functional capacity of individuals and to identify their potential interactions. Processing this data could ultimately allow the development of a model to determine a composite standard profile of "dysmobility" in patients with chronic disease.

In the present protocol, parameters will be measured on five occasions (at inclusion, at 6 months from the inclusion day, at 1,2 and 5 year(s) from the inclusion day). All tests will be performed on the same day. New assessments will be done on the same principle as the initial evaluation.

Statistical analyses will be carried out using Stata software (version 13, StataCorp, College Station, USA). Data will be described by frequencies and percentages for categorical variables and by means and standard deviation (or median and interquartile range if data are not normally distributed) for continuous variables. The normality of continuous data will be assessed graphically and using the Shapiro-Wilk test. The main analysis will consist in determining patient profiles regarding their mobility. Clustering-type approaches (supervised or not) will be proposed: k-means, vector machine support, machine learning, factor analysis. For example, factor analyses on mixed data will allow the main components of mobility to be characterized. They can be followed by an ascending hierarchical classification in order to determine homogeneous groups of patients.

These groups will be described and compared on the main criteria evaluated using standard statistical tests: chi2 test (or Fisher's exact test if applicable) for the categorical criteria and using an analysis of variance (or Kruskal-Wallis if data are not normally distributed) for continuous criteria. The main analysis will be broken down more specifically for each of the pathologies considered. In addition, the sensitivity to change will be assessed in each pathology and for each assessment criterion. The search for factors related to the evolution of the different criteria will be carried out using usual tests and mixed multivariate models (logistics for categorical / linear criteria for continuous criteria) considering the subject as a random effect, and adjusting on the time criteria (inclusion / follow-up) and the criteria highlighted in the univariate analyses and in light of the elements reported in the literature. A sensitivity analysis will be proposed in order to study the statistical nature of the missing data and to propose, if necessary, the most suitable method of imputing the data: multiple imputation, maximum bias or LOCF in the case of longitudinal data.

研究类型

介入性

注册 (估计的)

5000

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

学习地点

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 90年 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

描述

Inclusion Criteria:

  • Man or woman aged 18 to 90.
  • Patients with chronic pathology contributing to impaired mobility.
  • Volunteers who have given their written consent.
  • Affiliated to French health care system (for France)

Exclusion Criteria:

  • Patients suffering from progressive psychiatric pathologies (active psychosis, hallucinations, etc.) or the presence of another serious unstabilized pathology (decompensated heart failure, progressive terminal cancer, etc.).
  • People with poorly controlled or unstable cardiovascular disease.
  • Major osteoarticular or neurological problems completely preventing the proper performance of the various tests.
  • Non-autonomous patient
  • Persons under guardianship, curatorship, deprived of liberty or safeguarding justice.
  • People excluded from another study.
  • Pregnant or lactating women.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：诊断
  • 分配：不适用
  • 介入模型：单组作业
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：Cohort 1

Participants will be involved in a long-term evaluation program combining, body composition measures, physical tests as well as self-administered questionnaires. Participants will be followed for 5 years with evaluations taking place at inclusion, 6 months, at 1, 2 and 5 years
其他：Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.

Firstly, volunteers will be invited to complete online questionnaires on a secure platform. The mobility assessment will be carried out initially (t1) and up to a maximum of 4 times (t1 to t4) as part of a day hospitalization. Questionnaires will be diverse (SF36, KOOS, HOOS, BROCKER, MNA, TAMPA, etc.) in order to assess several aspects that compose mobility.

Physical evaluations will include various validated tests (isokinetic strength measure, TUG, 6MWT, Berg Balance Scale, etc.)

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
dismobility score calculated from the results reported in secondary outcomes
大体时间：Day 0

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Day 0
dismobility score calculated from the results reported in secondary outcomes
大体时间：Month 6

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Month 6
dismobility score calculated from the results reported in secondary outcomes
大体时间：Year 1

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 1
dismobility score calculated from the results reported in secondary outcomes
大体时间：Year 2

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 2
dismobility score calculated from the results reported in secondary outcomes
大体时间：Year 5

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 5

次要结果测量

结果测量
措施说明
大体时间
The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
大体时间：Day 0

Demographics information will be obtained using a single questionnaire including questions on age, gender, qualification, personal work status, ethnicity, life and occupational events.
Day 0
Weight (Kg).
大体时间：Day 0

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Day 0
Weight (Kg).
大体时间：Month 6

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Month 6
Weight (Kg).
大体时间：Year 1

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 1
Weight (Kg).
大体时间：Year 2

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 2
Weight (Kg).
大体时间：Year 5

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 5
Height (cm).
大体时间：Day 0

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Day 0
Height (cm).
大体时间：Month 6

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Month 6
Height (cm).
大体时间：Year 1

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 1
Height (cm).
大体时间：Year 2

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 2
Height (cm).
大体时间：Year 5

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 5
Body fat percentage (%).
大体时间：Day 0

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Day 0
Body fat percentage (%).
大体时间：Month 6

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Month 6
Body fat percentage (%).
大体时间：Year 1

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 1
Body fat percentage (%).
大体时间：Year 2

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 2
Body fat percentage (%).
大体时间：Year 5

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 5
Waist circumference (cm).
大体时间：Day 0

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Waist circumference (cm).
大体时间：Month 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 5
Waist circumference (cm).
大体时间：Year 1

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Waist circumference (cm).
大体时间：Year 2

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Waist circumference (cm).
大体时间：Year 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Hip circumference (cm).
大体时间：Day 0

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Hip circumference (cm).
大体时间：Month 6

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Hip circumference (cm).
大体时间：Year 1

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Hip circumference (cm).
大体时间：Year 2

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Hip circumference (cm).
大体时间：Year 5

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Brachial circumference (cm).
大体时间：Day 0

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Brachial circumference (cm).
大体时间：Month 6

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Brachial circumference (cm).
大体时间：Year 1

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Brachial circumference (cm).
大体时间：Year 2

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Brachial circumference (cm).
大体时间：Year 5

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Calf circumference (cm).
大体时间：Day 0

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Calf circumference (cm).
大体时间：Month 6

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 6
Calf circumference (cm).
大体时间：Year 1

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Calf circumference (cm).
大体时间：Year 2

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Calf circumference (cm).
大体时间：Year 5

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Body Mass Index (Kg/m²).
大体时间：Day 0

BMI will be calculated (weight in kilograms divided by height in meters squared).
Day 0
Body Mass Index (Kg/m²).
大体时间：Month 6

BMI will be calculated (weight in kilograms divided by height in meters squared).
Month 6
Body Mass Index (Kg/m²).
大体时间：Year 1

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 1
Body Mass Index (Kg/m²).
大体时间：Year 2

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 2
Body Mass Index (Kg/m²).
大体时间：Year 5

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 5
Body composition
大体时间：Day 0

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Day 0
Body composition
大体时间：Month 6

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Month 6
Body composition
大体时间：Year 1

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 1
Body composition
大体时间：Year 2

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 2
Body composition
大体时间：Year 5

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 5
T-score (DS).
大体时间：DAy 0

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
DAy 0
T-score (DS).
大体时间：Month 6

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
T-score (DS).
大体时间：Year 1

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
T-score (DS).
大体时间：Year 2

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
T-score (DS).
大体时间：Year 5

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Z-score (DS).
大体时间：Day 0

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Z-score (DS).
大体时间：Month 6

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Z-score (DS).
大体时间：Year 1

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Z-score (DS).
大体时间：Year 2

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Z-score (DS).
大体时间：Year 5

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Fat mass
大体时间：Day 0

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mass
大体时间：Month 6

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mass
大体时间：Year 1

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mass
大体时间：Year 2

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mass
大体时间：Year 5

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass (%).
大体时间：Day 0

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass (%).
大体时间：Month 6

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass (%).
大体时间：Year 1

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass (%).
大体时间：Year 2

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass (%).
大体时间：Year 5

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat mas index (Kg/m²).
大体时间：Day 0

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mas index (Kg/m²).
大体时间：Month 6

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mas index (Kg/m²).
大体时间：Year 1

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mas index (Kg/m²).
大体时间：Year 2

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mas index (Kg/m²).
大体时间：Year 5

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Ratio of android to gynoid fat mass.
大体时间：Day 0

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Ratio of android to gynoid fat mass.
大体时间：Month 6

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Ratio of android to gynoid fat mass.
大体时间：Year 1

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Ratio of android to gynoid fat mass.
大体时间：Year 2

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Ratio of android to gynoid fat mass.
大体时间：Year 5

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Visceral adipose tissue (Kg).
大体时间：Day 0

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Visceral adipose tissue (Kg).
大体时间：Month 6

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Visceral adipose tissue (Kg).
大体时间：Year 1

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Visceral adipose tissue (Kg).
大体时间：Year 2

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Visceral adipose tissue (Kg).
大体时间：Year 5

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass index (kg/m²).
大体时间：Day 0

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass index (kg/m²).
大体时间：Month 6

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass index (kg/m²).
大体时间：Year 1

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass index (kg/m²).
大体时间：Year 2

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass index (kg/m²).
大体时间：Year 5

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Appendicular fat-free mass index (Kg/m²).
大体时间：Day 0

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Appendicular fat-free mass index (Kg/m²).
大体时间：Month 6

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Appendicular fat-free mass index (Kg/m²).
大体时间：Year 1

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Appendicular fat-free mass index (Kg/m²).
大体时间：Year 2

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Appendicular fat-free mass index (Kg/m²).
大体时间：Year 5

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Bone mass (Kg)
大体时间：Day 0

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Bone mass (Kg)
大体时间：Month 6

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Bone mass (Kg)
大体时间：Year 1

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Bone mass (Kg)
大体时间：Year 2

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Bone mass (Kg)
大体时间：Year 5

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Daily caloric intake (Kcal/24h).
大体时间：Day 0

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily caloric intake (Kcal/24h).
大体时间：Month 6

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily caloric intake (Kcal/24h).
大体时间：Year 1

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily caloric intake (Kcal/24h).
大体时间：Year 2

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily caloric intake (Kcal/24h).
大体时间：Year 5

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily protein intake (in g and as a percentage of total caloric intake).
大体时间：Day 0

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily protein intake (in g and as a percentage of total caloric intake).
大体时间：Month 6

Daily protein intake (in g and as a percentage of total caloric intake).
Month 6
Daily protein intake (in g and as a percentage of total caloric intake).
大体时间：Year 1

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily protein intake (in g and as a percentage of total caloric intake).
大体时间：Year 2

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily protein intake (in g and as a percentage of total caloric intake).
大体时间：Year 5

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
大体时间：Day 0

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
大体时间：Month 6

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
大体时间：Year 1

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
大体时间：Year 2

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
大体时间：Year 5

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily fat intake (in g and as a percentage of total caloric intake).
大体时间：Day 0

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily fat intake (in g and as a percentage of total caloric intake).
大体时间：Month 6

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily fat intake (in g and as a percentage of total caloric intake).
大体时间：Year 1

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily fat intake (in g and as a percentage of total caloric intake).
大体时间：Year 2

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily fat intake (in g and as a percentage of total caloric intake).
大体时间：Year 5

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Nutritional status assessment
大体时间：Day 0

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Day 0
Nutritional status assessment
大体时间：Month 6

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Month 6
Nutritional status assessment
大体时间：Year 1

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 1
Nutritional status assessment
大体时间：Year 2

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 2
Nutritional status assessment
大体时间：Year 5

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 5
Risk of undernutrition.
大体时间：Day 0

Risk of undernutrition will be assessed with the Brocker Questionnaire
Day 0
Risk of undernutrition.
大体时间：Month 6

Risk of undernutrition will be assessed with the Brocker Questionnaire
Month 6
Risk of undernutrition.
大体时间：Year 1

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 1
Risk of undernutrition.
大体时间：Year 2

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 2
Risk of undernutrition.
大体时间：Year 5

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 5
Basic biology.
大体时间：Day 0

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Day 0
Basic biology.
大体时间：Month 6

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Month 6
Basic biology.
大体时间：Year 1

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 1
Basic biology.
大体时间：Year 2

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 2
Basic biology.
大体时间：Year 5

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 5
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
大体时间：Day 0

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
大体时间：Month 6

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
大体时间：Year 1

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
大体时间：Year 2

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
大体时间：Year 5

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
大体时间：Day 0

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
大体时间：Month 6

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
大体时间：Year 1

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
大体时间：Year 2

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
大体时间：Year 5

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
大体时间：Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
大体时间：Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
大体时间：Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
大体时间：Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
大体时间：Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
大体时间：Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
大体时间：Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
大体时间：Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
大体时间：Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
大体时间：Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
大体时间：Day 0

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
大体时间：Month 6

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
大体时间：Year 1

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
大体时间：Year 2

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
大体时间：Year 5

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
大体时间：Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the quadriceps muscles at 180°/s.
大体时间：Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Day 0
Endurance coefficient of the quadriceps muscles at 180°/s.
大体时间：Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Month 6
Endurance coefficient of the quadriceps muscles at 180°/s.
大体时间：Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 1
Endurance coefficient of the quadriceps muscles at 180°/s.
大体时间：Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 2
Endurance coefficient of the quadriceps muscles at 180°/s.
大体时间：Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the hamstring muscles at 180°/s.
大体时间：Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Day 0
Endurance coefficient of the hamstring muscles at 180°/s.
大体时间：Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Month 6
Endurance coefficient of the hamstring muscles at 180°/s.
大体时间：Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 1
Endurance coefficient of the hamstring muscles at 180°/s.
大体时间：Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 2
Endurance coefficient of the hamstring muscles at 180°/s.
大体时间：Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 5
Functional ratio
大体时间：Day 0

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Day 0
Functional ratio
大体时间：Month 6

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Month 6
Functional ratio
大体时间：Year 1

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 1
Functional ratio
大体时间：Year 2

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 2
Functional ratio
大体时间：Year 5

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 5
Mixed ratio
大体时间：Day 0

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Day 0
Mixed ratio
大体时间：Month 6

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Month 6
Mixed ratio
大体时间：Year 1

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 1
Mixed ratio
大体时间：Year 2

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 2
Mixed ratio
大体时间：Year 5

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 5
Maximum voluntary hand grip strength (Kg).
大体时间：Day 0

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Day 0
Maximum voluntary hand grip strength (Kg).
大体时间：Month 6

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Month 6
Maximum voluntary hand grip strength (Kg).
大体时间：Year 1

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 1
Maximum voluntary hand grip strength (Kg).
大体时间：Year 2

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 2
Maximum voluntary hand grip strength (Kg).
大体时间：Year 5

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 5
Maximum voluntary pinch strength (Kg).
大体时间：Day 0

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Day 0
Maximum voluntary pinch strength (Kg).
大体时间：Month 6

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Month 6
Maximum voluntary pinch strength (Kg).
大体时间：Year 1

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 1
Maximum voluntary pinch strength (Kg).
大体时间：Year 2

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 2
Maximum voluntary pinch strength (Kg).
大体时间：Year 5

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 5
Hip passive joint range
大体时间：Day 0

Hip joint range will be measured with a medical goniometer.
Day 0
Hip passive joint range
大体时间：Month 6

Hip joint range will be measured with a medical goniometer.
Month 6
Hip passive joint range
大体时间：Year 1

Hip joint range will be measured with a medical goniometer.
Year 1
Hip passive joint range
大体时间：Year 2

Hip joint range will be measured with a medical goniometer.
Year 2
Hip passive joint range
大体时间：Year 5

Hip joint range will be measured with a medical goniometer.
Year 5
Knee passive joint range.
大体时间：Day 0

Knee joint range will be measured with a medical goniometer.
Day 0
Knee passive joint range.
大体时间：Month 6

Knee joint range will be measured with a medical goniometer.
Month 6
Knee passive joint range.
大体时间：Year 1

Knee joint range will be measured with a medical goniometer.
Year 1
Knee passive joint range.
大体时间：Year 2

Knee joint range will be measured with a medical goniometer.
Year 2
Knee passive joint range.
大体时间：Year 5

Knee joint range will be measured with a medical goniometer.
Year 5
Ankle passive joint range
大体时间：Day 0

Ankle joint range will be measured with a medical goniometer.
Day 0
Ankle passive joint range
大体时间：Month 6

Ankle joint range will be measured with a medical goniometer.
Month 6
Ankle passive joint range
大体时间：Year 1

Ankle joint range will be measured with a medical goniometer.
Year 1
Ankle passive joint range
大体时间：Year 2

Ankle joint range will be measured with a medical goniometer.
Year 2
Ankle passive joint range
大体时间：Year 5

Ankle joint range will be measured with a medical goniometer.
Year 5
Lower and upper limb muscle power assessment (MRC)
大体时间：Day 0

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Day 0
Lower and upper limb muscle power assessment (MRC)
大体时间：Month 6

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Month 6
Lower and upper limb muscle power assessment (MRC)
大体时间：Year 1

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 1
Lower and upper limb muscle power assessment (MRC)
大体时间：Year 2

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 2
Lower and upper limb muscle power assessment (MRC)
大体时间：Year 5

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 5
Statokinesigram surface area (mm²)
大体时间：Day 0

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Day 0
Statokinesigram surface area (mm²)
大体时间：Month 6

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Month 6
Statokinesigram surface area (mm²)
大体时间：Year 1

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 1
Statokinesigram surface area (mm²)
大体时间：Year 2

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 2
Statokinesigram surface area (mm²)
大体时间：Year 5

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 5
Stabilogram length (mm).
大体时间：Day 0

Stabilogram length will be measured with the STATIPRO® static posturography platform
Day 0
Stabilogram length (mm).
大体时间：Month 6

Stabilogram length will be measured with the STATIPRO® static posturography platform
Month 6
Stabilogram length (mm).
大体时间：Year 1

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 1
Stabilogram length (mm).
大体时间：Year 2

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 2
Stabilogram length (mm).
大体时间：Year 5

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 5
Maximal deflection (forward, backward left and right).
大体时间：Day 0

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Day 0
Maximal deflection (forward, backward left and right).
大体时间：Month 6

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Month 6
Maximal deflection (forward, backward left and right).
大体时间：Year 1

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 1
Maximal deflection (forward, backward left and right).
大体时间：Year 2

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 2
Maximal deflection (forward, backward left and right).
大体时间：Year 5

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 5
Velocity variations (mm/s).
大体时间：Day 0

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Day 0
Velocity variations (mm/s).
大体时间：Month 6

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Month 6
Velocity variations (mm/s).
大体时间：Year 1

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 1
Velocity variations (mm/s).
大体时间：Year 2

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 2
Velocity variations (mm/s).
大体时间：Year 5

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 5
: Romberg ratio according to sway area
大体时间：Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
: Romberg ratio according to sway area
大体时间：Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
: Romberg ratio according to sway area
大体时间：Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
: Romberg ratio according to sway area
大体时间：Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
: Romberg ratio according to sway area
大体时间：Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
Romberg ratio according to center of pressure path length
大体时间：Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
Romberg ratio according to center of pressure path length
大体时间：Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
Romberg ratio according to center of pressure path length
大体时间：Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
Romberg ratio according to center of pressure path length
大体时间：Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
Romberg ratio according to center of pressure path length
大体时间：Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
: Plantar pressure ratio sway area.
大体时间：Day 0

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Day 0
: Plantar pressure ratio sway area.
大体时间：Month 6

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Month 6
: Plantar pressure ratio sway area.
大体时间：Year 1

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 1
: Plantar pressure ratio sway area.
大体时间：Year 2

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 2
: Plantar pressure ratio sway area.
大体时间：Year 5

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 5
Plantar pressure ratio length.
大体时间：Day 0

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Day 0
Plantar pressure ratio length.
大体时间：Month 6

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Month 6
Plantar pressure ratio length.
大体时间：Year 1

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 1
Plantar pressure ratio length.
大体时间：Year 2

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 2
Plantar pressure ratio length.
大体时间：Year 5

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 5
Walking velocity (cm/s).
大体时间：Day 0

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Day 0
Walking velocity (cm/s).
大体时间：Month 6

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Month 6
Walking velocity (cm/s).
大体时间：Year 1

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 1
Walking velocity (cm/s).
大体时间：Year 2

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 2
Walking velocity (cm/s).
大体时间：Year 5

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 5
Cadence (steps/min).
大体时间：Day 0

: Cadence will be measured with the GAITRite® Electronic Walkway.
Day 0
Cadence (steps/min).
大体时间：Month 6

: Cadence will be measured with the GAITRite® Electronic Walkway.
Month 6
Cadence (steps/min).
大体时间：Year 1

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 1
Cadence (steps/min).
大体时间：Year 2

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 2
Cadence (steps/min).
大体时间：Year 5

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 5
Step length (left and right foot) (cm)
大体时间：DAy 0

Step length will be measured with the GAITRite® Electronic Walkway.
DAy 0
Step length (left and right foot) (cm)
大体时间：Month 6

Step length will be measured with the GAITRite® Electronic Walkway.
Month 6
Step length (left and right foot) (cm)
大体时间：Year 1

Step length will be measured with the GAITRite® Electronic Walkway.
Year 1
Step length (left and right foot) (cm)
大体时间：Year 2

Step length will be measured with the GAITRite® Electronic Walkway.
Year 2
Step length (left and right foot) (cm)
大体时间：Year 5

Step length will be measured with the GAITRite® Electronic Walkway.
Year 5
Stride length (cm).
大体时间：Day 0

Stride length will be measured with the GAITRite® Electronic Walkway.
Day 0
Stride length (cm).
大体时间：month 6

Stride length will be measured with the GAITRite® Electronic Walkway.
month 6
Stride length (cm).
大体时间：year 1

Stride length will be measured with the GAITRite® Electronic Walkway.
year 1
Stride length (cm).
大体时间：year 2

Stride length will be measured with the GAITRite® Electronic Walkway.
year 2
Stride length (cm).
大体时间：year 5

Stride length will be measured with the GAITRite® Electronic Walkway.
year 5
Single support time left and right foot (s).
大体时间：Day 0

Single support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Single support time left and right foot (s).
大体时间：Month 6

Single support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Single support time left and right foot (s).
大体时间：Year 1

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 1
Single support time left and right foot (s).
大体时间：Year 2

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Single support time left and right foot (s).
大体时间：Year 5

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Double support time (s).
大体时间：Day 0

: Double support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Double support time (s).
大体时间：Month 6

: Double support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Double support time (s).
大体时间：YEar 1

: Double support time will be measured with the GAITRite® Electronic Walkway.
YEar 1
Double support time (s).
大体时间：Year 2

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Double support time (s).
大体时间：Year 5

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing time (s).
大体时间：Day 0

: Swing time will be measured with the GAITRite® Electronic Walkway.
Day 0
Swing time (s).
大体时间：Month 6

: Swing time will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing time (s).
大体时间：Year 1

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing time (s).
大体时间：Year 2

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing time (s).
大体时间：Year 5

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing phase (as a % of walking cycle).
大体时间：DAy 0

: Swing phase will be measured with the GAITRite® Electronic Walkway.
DAy 0
Swing phase (as a % of walking cycle).
大体时间：Month 6

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing phase (as a % of walking cycle).
大体时间：Year 1

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing phase (as a % of walking cycle).
大体时间：Year 2

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing phase (as a % of walking cycle).
大体时间：Year 5

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Stance phase (as a % of walking cycle).
大体时间：Day 0

Stance phase will be measured with the GAITRite® Electronic Walkway.
Day 0
Stance phase (as a % of walking cycle).
大体时间：Month 6

Stance phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Stance phase (as a % of walking cycle).
大体时间：Year 1

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Stance phase (as a % of walking cycle).
大体时间：Year 2

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Stance phase (as a % of walking cycle).
大体时间：Year 5

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Vo2max (maximal oxygen consumption) (mL/Kg/min).
大体时间：Day 0

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Vo2max (maximal oxygen consumption) (mL/Kg/min).
大体时间：Month 6

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Vo2max (maximal oxygen consumption) (mL/Kg/min).
大体时间：Year 1

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Vo2max (maximal oxygen consumption) (mL/Kg/min).
大体时间：Year 2

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Vo2max (maximal oxygen consumption) (mL/Kg/min).
大体时间：Year 5

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum heart rate (bpm).
大体时间：Day 0

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum heart rate (bpm).
大体时间：Month 6

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum heart rate (bpm).
大体时间：Year 1

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum heart rate (bpm).
大体时间：Year 2

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum heart rate (bpm).
大体时间：Year 5

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum power (Watts).
大体时间：Day 0

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum power (Watts).
大体时间：Month 6

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum power (Watts).
大体时间：Year 1

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum power (Watts).
大体时间：Year 2

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum power (Watts).
大体时间：Year 5

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold power (Watts).
大体时间：Day 0

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Threshold power (Watts).
大体时间：Month 6

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold power (Watts).
大体时间：Year 1

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold power (Watts).
大体时间：Year 2

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold power (Watts).
大体时间：Year 5

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold heart rate (bpm).
大体时间：DAy 0

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
DAy 0
Threshold heart rate (bpm).
大体时间：Month 6

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold heart rate (bpm).
大体时间：Year 1

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold heart rate (bpm).
大体时间：Year 2

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold heart rate (bpm).
大体时间：Year 5

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Forced vital Capacity (L).
大体时间：Day 0

: Forced vital Capacity will be measured with a spirometry test.
Day 0
Forced vital Capacity (L).
大体时间：Month 6

: Forced vital Capacity will be measured with a spirometry test.
Month 6
Forced vital Capacity (L).
大体时间：Year 1

: Forced vital Capacity will be measured with a spirometry test.
Year 1
Forced vital Capacity (L).
大体时间：Year 2

: Forced vital Capacity will be measured with a spirometry test.
Year 2
Forced vital Capacity (L).
大体时间：Year 5

: Forced vital Capacity will be measured with a spirometry test.
Year 5
Forced Expiratory volume (L)
大体时间：Day 0

Forced Expiratory volume will be measured with a spirometry test.
Day 0
Forced Expiratory volume (L)
大体时间：Month 6

Forced Expiratory volume will be measured with a spirometry test.
Month 6
Forced Expiratory volume (L)
大体时间：Year 1

Forced Expiratory volume will be measured with a spirometry test.
Year 1
Forced Expiratory volume (L)
大体时间：Year 2

Forced Expiratory volume will be measured with a spirometry test.
Year 2
Forced Expiratory volume (L)
大体时间：Year 5

Forced Expiratory volume will be measured with a spirometry test.
Year 5
Tiffeneau ratio (%).
大体时间：Day 0

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Day 0
Tiffeneau ratio (%).
大体时间：Month 6

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Month 6
Tiffeneau ratio (%).
大体时间：Year 1

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 1
Tiffeneau ratio (%).
大体时间：Year 2

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 2
Tiffeneau ratio (%).
大体时间：Year 5

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 5
Ventilatory reserve (%).
大体时间：Day 0

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Ventilatory reserve (%).
大体时间：Month 6

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Ventilatory reserve (%).
大体时间：Year 1

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Ventilatory reserve (%).
大体时间：Year 2

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Ventilatory reserve (%).
大体时间：Year 5

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Physical activity
大体时间：Day 0

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Day 0
Physical activity
大体时间：Month 6

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Month 6
Physical activity
大体时间：Year 1

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 1
Physical activity
大体时间：Year 2

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 2
Physical activity
大体时间：Year 5

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 5
Functional capacity timed-up and go
大体时间：Day 0

Functional capacity will be evaluated using the Timed-Up and Go test.
Day 0
Functional capacity timed-up and go
大体时间：Month 6

Functional capacity will be evaluated using the Timed-Up and Go test.
Month 6
Functional capacity timed-up and go
大体时间：Year 1

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 1
Functional capacity timed-up and go
大体时间：Year 2

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 2
Functional capacity timed-up and go
大体时间：Year 5

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 5
Functional capacity TDM6
大体时间：Day 0

Functional capacity will be evaluated using the 6-minute walk test.
Day 0
Functional capacity TDM6
大体时间：Month 6

Functional capacity will be evaluated using the 6-minute walk test.
Month 6
Functional capacity TDM6
大体时间：Year 1

Functional capacity will be evaluated using the 6-minute walk test.
Year 1
Functional capacity TDM6
大体时间：Year 2

Functional capacity will be evaluated using the 6-minute walk test.
Year 2
Functional capacity TDM6
大体时间：Year 5

Functional capacity will be evaluated using the 6-minute walk test.
Year 5
Functional capacity Five Times Sit to Stand test.
大体时间：Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Day 0
Functional capacity Five Times Sit to Stand test.
大体时间：Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Month 6
Functional capacity Five Times Sit to Stand test.
大体时间：Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 1
Functional capacity Five Times Sit to Stand test.
大体时间：Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 2
Functional capacity Five Times Sit to Stand test.
大体时间：Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 5
Functional capacity SPPB
大体时间：Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Day 0
Functional capacity SPPB
大体时间：Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Month 6
Functional capacity SPPB
大体时间：Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 1
Functional capacity SPPB
大体时间：Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 2
Functional capacity SPPB
大体时间：Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 5
Functional capacity the mini-BESTest.
大体时间：Day 0

Functional capacity will be evaluated using the mini-BESTest.
Day 0
Functional capacity the mini-BESTest.
大体时间：Month 6

Functional capacity will be evaluated using the mini-BESTest.
Month 6
Functional capacity the mini-BESTest.
大体时间：Year 1

Functional capacity will be evaluated using the mini-BESTest.
Year 1
Functional capacity the mini-BESTest.
大体时间：Year 2

Functional capacity will be evaluated using the mini-BESTest.
Year 2
Functional capacity the mini-BESTest.
大体时间：Year 5

Functional capacity will be evaluated using the mini-BESTest.
Year 5
Functional capacity Berg Balance Scale.
大体时间：Day 0

Functional capacity will be evaluated using the Berg Balance Scale.
Day 0
Functional capacity Berg Balance Scale.
大体时间：Month 6

Functional capacity will be evaluated using the Berg Balance Scale.
Month 6
Functional capacity Berg Balance Scale.
大体时间：Year 1

Functional capacity will be evaluated using the Berg Balance Scale.
Year 1
Functional capacity Berg Balance Scale.
大体时间：Year 2

Functional capacity will be evaluated using the Berg Balance Scale.
Year 2
Functional capacity Berg Balance Scale.
大体时间：Year 5

Functional capacity will be evaluated using the Berg Balance Scale.
Year 5
Functional capacity 10-meter walk test
大体时间：Day 0

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Day 0
Functional capacity 10-meter walk test
大体时间：Month 6

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Month 6
Functional capacity 10-meter walk test
大体时间：Year 1

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 1
Functional capacity 10-meter walk test
大体时间：Year 2

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 2
Functional capacity 10-meter walk test
大体时间：Year 5

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 5
Dyspnea
大体时间：Day 0

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Day 0
Dyspnea
大体时间：Month 6

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Dyspnea
大体时间：Year 1

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Dyspnea
大体时间：Year 2

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Dyspnea
大体时间：Year 5

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Perceived exertion before, during and after effort
大体时间：DAy 0

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
DAy 0
Perceived exertion before, during and after effort
大体时间：Month 6

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Perceived exertion before, during and after effort
大体时间：Year 1

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Perceived exertion before, during and after effort
大体时间：Year 2

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Perceived exertion before, during and after effort
大体时间：Year 5

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Musculoskeletal Pain
大体时间：Day 0

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Day 0
Musculoskeletal Pain
大体时间：Month 6

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Month 6
Musculoskeletal Pain
大体时间：Year 1

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 1
Musculoskeletal Pain
大体时间：Year 2

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 2
Musculoskeletal Pain
大体时间：Year 5

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 5
Sarcopenia risk
大体时间：Day 0

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Day 0
Sarcopenia risk
大体时间：Month 6

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Month 6
Sarcopenia risk
大体时间：Year 1

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 1
Sarcopenia risk
大体时间：Year 2

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 2
Sarcopenia risk
大体时间：Year 5

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 5
Social insecurity
大体时间：Day 0

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Day 0
Social insecurity
大体时间：Month 6

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Month 6
Social insecurity
大体时间：Year 1

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 1
Social insecurity
大体时间：Year 2

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 2
Social insecurity
大体时间：Year 5

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 5
Kinesiophobia
大体时间：Day 0

Kinesiophobia will be evaluated with the TAMPA Scale.
Day 0
Kinesiophobia
大体时间：Month 6

Kinesiophobia will be evaluated with the TAMPA Scale.
Month 6
Kinesiophobia
大体时间：Year 1

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 1
Kinesiophobia
大体时间：Year 2

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 2
Kinesiophobia
大体时间：Year 5

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 5
Quality of life
大体时间：Day 0

Quality of life will be evaluated with the 36-Item Short Form Survey.
Day 0
Quality of life
大体时间：Month 6

Quality of life will be evaluated with the 36-Item Short Form Survey.
Month 6
Quality of life
大体时间：Year 1

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 1
Quality of life
大体时间：Year 2

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 2
Quality of life
大体时间：Year 5

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 5
: Balance confidence in performing various activities
大体时间：Day 0

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Day 0
: Balance confidence in performing various activities
大体时间：Month 6

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Month 6
: Balance confidence in performing various activities
大体时间：Year 1

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 1
: Balance confidence in performing various activities
大体时间：Year 2

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 2
: Balance confidence in performing various activities
大体时间：Year 5

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 5
Functioning in regards to activities of daily living.
大体时间：Day 0

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Day 0
Functioning in regards to activities of daily living.
大体时间：Month 6

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Month 6
Functioning in regards to activities of daily living.
大体时间：Year 1

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 1
Functioning in regards to activities of daily living.
大体时间：Year 2

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 2
Functioning in regards to activities of daily living.
大体时间：Year 5

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 5
Exhaustion
大体时间：Day 0

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Day 0
Exhaustion
大体时间：Month 6

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Month 6
Exhaustion
大体时间：Year 1

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 1
Exhaustion
大体时间：Year 2

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 2
Exhaustion
大体时间：Year 5

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 5
Patient's opinion about their knee and associated problems
大体时间：Day 0

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Day 0
Patient's opinion about their knee and associated problems
大体时间：Month 6

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Month 6
Patient's opinion about their knee and associated problems
大体时间：Year 1

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 1
Patient's opinion about their knee and associated problems
大体时间：Year 2

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 2
Patient's opinion about their knee and associated problems
大体时间：Year 5

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 5
Patient's opinion about their hip and associated problems
大体时间：Day 0

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Day 0
Patient's opinion about their hip and associated problems
大体时间：Month 6

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Month 6
Patient's opinion about their hip and associated problems
大体时间：Year 1

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 1
Patient's opinion about their hip and associated problems
大体时间：Year 2

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 2
Patient's opinion about their hip and associated problems
大体时间：Year 5

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 5
Predicting discharge destination after total joint arthroplasty.
大体时间：Day 0

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Day 0
Predicting discharge destination after total joint arthroplasty.
大体时间：Month 6

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Month 6
Physical function in myositis patients
大体时间：Day 0

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Day 0
Physical function in myositis patients
大体时间：Month 6

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Month 6
Physical function in myositis patients
大体时间：Year 1

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 1
Physical function in myositis patients
大体时间：Year 2

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 2
Physical function in myositis patients
大体时间：Year 5

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 5
Quality of life in Parkinson's Disease
大体时间：Day 0

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Day 0
Quality of life in Parkinson's Disease
大体时间：Month 6

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Month 6
Quality of life in Parkinson's Disease
大体时间：Year 1

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 1
Quality of life in Parkinson's Disease
大体时间：Year 2

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 2
Quality of life in Parkinson's Disease
大体时间：Year 5

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 5
Actimetry.
大体时间：during 5 consecutive days after day 0

Actimetry data (energy expenditure, number of steps, sedentary time, total physical activity, etc.) will be obtained with the WGT3X-BT Actigraph inertial sensor unit.
during 5 consecutive days after day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
大体时间：Day 0

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
大体时间：Month 6

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
大体时间：Year 1

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
大体时间：Year 2

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
大体时间：Year 5

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
大体时间：Day 0

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
大体时间：Month 6

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
大体时间：Year 1

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
大体时间：Year 2

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
大体时间：Year 5

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
大体时间：Day 0

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
大体时间：Month 6

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
大体时间：Year 1

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
大体时间：Year 2

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
大体时间：Year 5

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
大体时间：Day 0

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
大体时间：Month 6

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
大体时间：Year 1

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
大体时间：Year 2

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
大体时间：Year 5

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
大体时间：Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
大体时间：Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
大体时间：Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

University Hospital, Clermont-Ferrand

合作者

I-SITE Cap 20-25 project

调查人员

  • 首席研究员：Frédéric Costes、University Hospital, Clermont-Ferrand

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2020年8月27日

初级完成 (估计的)

2035年8月26日

研究完成 (估计的)

2035年8月26日

研究注册日期

首次提交

2020年4月27日

首先提交符合 QC 标准的

2020年5月4日

首次发布 (实际的)

2020年5月5日

研究记录更新

最后更新发布 (实际的)

2026年11月4日

上次提交的符合 QC 标准的更新

2026年11月2日

最后验证

2026年10月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • RBHP 2019 COSTES
  • 2019-A01017-50 (其他标识符：2019-A01017-50)

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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