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Évaluation de la mobilité réduite dans la maladie chronique Constitution d'une cohorte (EVALMOB)

2 novembre 2026 mis à jour par: University Hospital, Clermont-Ferrand

Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge both for the treatment of causal pathologies, as well as for evaluating the impact of therapeutic interventions, the benefit of which will be an improvement in physical capacities and ultimately mobility. In view of the hypothesis of an increase in the prevalence of mobility disorders in this population, this approach is part of a logic of screening and improving the effectiveness of the care of these patients with a multidisciplinary evaluation of individual risks. The EVALMOB protocol was designed in order to try to determine a standard profile of "dysmobility" in patients with chronic illness

Aperçu de l'étude

Statut

Recrutement

Les conditions

Intervention / Traitement

Description détaillée

We propose to constitute a prospective cohort of subjects carrying chronic disease. The objective is to explore all the different components of mobility (balance, muscle force, body composition, walking ability, metabolism, etc.), to assess their impact on the functional capacity of individuals and to identify their potential interactions. Processing this data could ultimately allow the development of a model to determine a composite standard profile of "dysmobility" in patients with chronic disease.

In the present protocol, parameters will be measured on five occasions (at inclusion, at 6 months from the inclusion day, at 1,2 and 5 year(s) from the inclusion day). All tests will be performed on the same day. New assessments will be done on the same principle as the initial evaluation.

Statistical analyses will be carried out using Stata software (version 13, StataCorp, College Station, USA). Data will be described by frequencies and percentages for categorical variables and by means and standard deviation (or median and interquartile range if data are not normally distributed) for continuous variables. The normality of continuous data will be assessed graphically and using the Shapiro-Wilk test. The main analysis will consist in determining patient profiles regarding their mobility. Clustering-type approaches (supervised or not) will be proposed: k-means, vector machine support, machine learning, factor analysis. For example, factor analyses on mixed data will allow the main components of mobility to be characterized. They can be followed by an ascending hierarchical classification in order to determine homogeneous groups of patients.

These groups will be described and compared on the main criteria evaluated using standard statistical tests: chi2 test (or Fisher's exact test if applicable) for the categorical criteria and using an analysis of variance (or Kruskal-Wallis if data are not normally distributed) for continuous criteria. The main analysis will be broken down more specifically for each of the pathologies considered. In addition, the sensitivity to change will be assessed in each pathology and for each assessment criterion. The search for factors related to the evolution of the different criteria will be carried out using usual tests and mixed multivariate models (logistics for categorical / linear criteria for continuous criteria) considering the subject as a random effect, and adjusting on the time criteria (inclusion / follow-up) and the criteria highlighted in the univariate analyses and in light of the elements reported in the literature. A sensitivity analysis will be proposed in order to study the statistical nature of the missing data and to propose, if necessary, the most suitable method of imputing the data: multiple imputation, maximum bias or LOCF in the case of longitudinal data.

Type d'étude

Interventionnel

Inscription (Estimé)

5000

Phase

  • N'est pas applicable

Contacts et emplacements

Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.

Coordonnées de l'étude

Lieux d'étude

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

18 ans à 90 ans (Adulte, Adulte plus âgé)

Accepte les volontaires sains

Non

Sexes éligibles pour l'étude

Tout

La description

Inclusion Criteria:

  • Man or woman aged 18 to 90.
  • Patients with chronic pathology contributing to impaired mobility.
  • Volunteers who have given their written consent.
  • Affiliated to French health care system (for France)

Exclusion Criteria:

  • Patients suffering from progressive psychiatric pathologies (active psychosis, hallucinations, etc.) or the presence of another serious unstabilized pathology (decompensated heart failure, progressive terminal cancer, etc.).
  • People with poorly controlled or unstable cardiovascular disease.
  • Major osteoarticular or neurological problems completely preventing the proper performance of the various tests.
  • Non-autonomous patient
  • Persons under guardianship, curatorship, deprived of liberty or safeguarding justice.
  • People excluded from another study.
  • Pregnant or lactating women.

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

  • Objectif principal: Diagnostique
  • Répartition: N / A
  • Modèle interventionnel: Affectation à un seul groupe
  • Masquage: Aucun (étiquette ouverte)

Armes et Interventions

Groupe de participants / Bras
Intervention / Traitement
Expérimental: Cohort 1

Participants will be involved in a long-term evaluation program combining, body composition measures, physical tests as well as self-administered questionnaires. Participants will be followed for 5 years with evaluations taking place at inclusion, 6 months, at 1, 2 and 5 years
Autre: Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.

Firstly, volunteers will be invited to complete online questionnaires on a secure platform. The mobility assessment will be carried out initially (t1) and up to a maximum of 4 times (t1 to t4) as part of a day hospitalization. Questionnaires will be diverse (SF36, KOOS, HOOS, BROCKER, MNA, TAMPA, etc.) in order to assess several aspects that compose mobility.

Physical evaluations will include various validated tests (isokinetic strength measure, TUG, 6MWT, Berg Balance Scale, etc.)

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats
Description de la mesure
Délai
dismobility score calculated from the results reported in secondary outcomes
Délai: Day 0

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Day 0
dismobility score calculated from the results reported in secondary outcomes
Délai: Month 6

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Month 6
dismobility score calculated from the results reported in secondary outcomes
Délai: Year 1

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 1
dismobility score calculated from the results reported in secondary outcomes
Délai: Year 2

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 2
dismobility score calculated from the results reported in secondary outcomes
Délai: Year 5

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 5

Mesures de résultats secondaires

Mesure des résultats
Description de la mesure
Délai
The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Délai: Day 0

Demographics information will be obtained using a single questionnaire including questions on age, gender, qualification, personal work status, ethnicity, life and occupational events.
Day 0
Weight (Kg).
Délai: Day 0

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Day 0
Weight (Kg).
Délai: Month 6

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Month 6
Weight (Kg).
Délai: Year 1

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 1
Weight (Kg).
Délai: Year 2

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 2
Weight (Kg).
Délai: Year 5

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 5
Height (cm).
Délai: Day 0

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Day 0
Height (cm).
Délai: Month 6

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Month 6
Height (cm).
Délai: Year 1

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 1
Height (cm).
Délai: Year 2

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 2
Height (cm).
Délai: Year 5

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 5
Body fat percentage (%).
Délai: Day 0

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Day 0
Body fat percentage (%).
Délai: Month 6

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Month 6
Body fat percentage (%).
Délai: Year 1

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 1
Body fat percentage (%).
Délai: Year 2

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 2
Body fat percentage (%).
Délai: Year 5

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 5
Waist circumference (cm).
Délai: Day 0

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Waist circumference (cm).
Délai: Month 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 5
Waist circumference (cm).
Délai: Year 1

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Waist circumference (cm).
Délai: Year 2

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Waist circumference (cm).
Délai: Year 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Hip circumference (cm).
Délai: Day 0

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Hip circumference (cm).
Délai: Month 6

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Hip circumference (cm).
Délai: Year 1

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Hip circumference (cm).
Délai: Year 2

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Hip circumference (cm).
Délai: Year 5

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Brachial circumference (cm).
Délai: Day 0

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Brachial circumference (cm).
Délai: Month 6

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Brachial circumference (cm).
Délai: Year 1

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Brachial circumference (cm).
Délai: Year 2

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Brachial circumference (cm).
Délai: Year 5

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Calf circumference (cm).
Délai: Day 0

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Calf circumference (cm).
Délai: Month 6

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 6
Calf circumference (cm).
Délai: Year 1

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Calf circumference (cm).
Délai: Year 2

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Calf circumference (cm).
Délai: Year 5

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Body Mass Index (Kg/m²).
Délai: Day 0

BMI will be calculated (weight in kilograms divided by height in meters squared).
Day 0
Body Mass Index (Kg/m²).
Délai: Month 6

BMI will be calculated (weight in kilograms divided by height in meters squared).
Month 6
Body Mass Index (Kg/m²).
Délai: Year 1

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 1
Body Mass Index (Kg/m²).
Délai: Year 2

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 2
Body Mass Index (Kg/m²).
Délai: Year 5

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 5
Body composition
Délai: Day 0

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Day 0
Body composition
Délai: Month 6

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Month 6
Body composition
Délai: Year 1

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 1
Body composition
Délai: Year 2

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 2
Body composition
Délai: Year 5

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 5
T-score (DS).
Délai: DAy 0

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
DAy 0
T-score (DS).
Délai: Month 6

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
T-score (DS).
Délai: Year 1

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
T-score (DS).
Délai: Year 2

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
T-score (DS).
Délai: Year 5

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Z-score (DS).
Délai: Day 0

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Z-score (DS).
Délai: Month 6

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Z-score (DS).
Délai: Year 1

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Z-score (DS).
Délai: Year 2

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Z-score (DS).
Délai: Year 5

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Fat mass
Délai: Day 0

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mass
Délai: Month 6

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mass
Délai: Year 1

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mass
Délai: Year 2

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mass
Délai: Year 5

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass (%).
Délai: Day 0

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass (%).
Délai: Month 6

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass (%).
Délai: Year 1

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass (%).
Délai: Year 2

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass (%).
Délai: Year 5

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat mas index (Kg/m²).
Délai: Day 0

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mas index (Kg/m²).
Délai: Month 6

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mas index (Kg/m²).
Délai: Year 1

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mas index (Kg/m²).
Délai: Year 2

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mas index (Kg/m²).
Délai: Year 5

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Ratio of android to gynoid fat mass.
Délai: Day 0

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Ratio of android to gynoid fat mass.
Délai: Month 6

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Ratio of android to gynoid fat mass.
Délai: Year 1

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Ratio of android to gynoid fat mass.
Délai: Year 2

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Ratio of android to gynoid fat mass.
Délai: Year 5

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Visceral adipose tissue (Kg).
Délai: Day 0

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Visceral adipose tissue (Kg).
Délai: Month 6

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Visceral adipose tissue (Kg).
Délai: Year 1

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Visceral adipose tissue (Kg).
Délai: Year 2

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Visceral adipose tissue (Kg).
Délai: Year 5

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass index (kg/m²).
Délai: Day 0

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass index (kg/m²).
Délai: Month 6

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass index (kg/m²).
Délai: Year 1

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass index (kg/m²).
Délai: Year 2

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass index (kg/m²).
Délai: Year 5

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Appendicular fat-free mass index (Kg/m²).
Délai: Day 0

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Appendicular fat-free mass index (Kg/m²).
Délai: Month 6

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Appendicular fat-free mass index (Kg/m²).
Délai: Year 1

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Appendicular fat-free mass index (Kg/m²).
Délai: Year 2

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Appendicular fat-free mass index (Kg/m²).
Délai: Year 5

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Bone mass (Kg)
Délai: Day 0

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Bone mass (Kg)
Délai: Month 6

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Bone mass (Kg)
Délai: Year 1

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Bone mass (Kg)
Délai: Year 2

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Bone mass (Kg)
Délai: Year 5

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Daily caloric intake (Kcal/24h).
Délai: Day 0

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily caloric intake (Kcal/24h).
Délai: Month 6

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily caloric intake (Kcal/24h).
Délai: Year 1

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily caloric intake (Kcal/24h).
Délai: Year 2

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily caloric intake (Kcal/24h).
Délai: Year 5

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily protein intake (in g and as a percentage of total caloric intake).
Délai: Day 0

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily protein intake (in g and as a percentage of total caloric intake).
Délai: Month 6

Daily protein intake (in g and as a percentage of total caloric intake).
Month 6
Daily protein intake (in g and as a percentage of total caloric intake).
Délai: Year 1

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily protein intake (in g and as a percentage of total caloric intake).
Délai: Year 2

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily protein intake (in g and as a percentage of total caloric intake).
Délai: Year 5

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Délai: Day 0

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Délai: Month 6

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Délai: Year 1

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Délai: Year 2

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Délai: Year 5

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily fat intake (in g and as a percentage of total caloric intake).
Délai: Day 0

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily fat intake (in g and as a percentage of total caloric intake).
Délai: Month 6

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily fat intake (in g and as a percentage of total caloric intake).
Délai: Year 1

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily fat intake (in g and as a percentage of total caloric intake).
Délai: Year 2

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily fat intake (in g and as a percentage of total caloric intake).
Délai: Year 5

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Nutritional status assessment
Délai: Day 0

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Day 0
Nutritional status assessment
Délai: Month 6

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Month 6
Nutritional status assessment
Délai: Year 1

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 1
Nutritional status assessment
Délai: Year 2

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 2
Nutritional status assessment
Délai: Year 5

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 5
Risk of undernutrition.
Délai: Day 0

Risk of undernutrition will be assessed with the Brocker Questionnaire
Day 0
Risk of undernutrition.
Délai: Month 6

Risk of undernutrition will be assessed with the Brocker Questionnaire
Month 6
Risk of undernutrition.
Délai: Year 1

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 1
Risk of undernutrition.
Délai: Year 2

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 2
Risk of undernutrition.
Délai: Year 5

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 5
Basic biology.
Délai: Day 0

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Day 0
Basic biology.
Délai: Month 6

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Month 6
Basic biology.
Délai: Year 1

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 1
Basic biology.
Délai: Year 2

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 2
Basic biology.
Délai: Year 5

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 5
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Délai: Day 0

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Délai: Month 6

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Délai: Year 1

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Délai: Year 2

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Délai: Year 5

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Délai: Day 0

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Délai: Month 6

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Délai: Year 1

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Délai: Year 2

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Délai: Year 5

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Délai: Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Délai: Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Délai: Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Délai: Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Délai: Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Délai: Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Délai: Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Délai: Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Délai: Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Délai: Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Délai: Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Délai: Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Délai: Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Délai: Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Délai: Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Délai: Day 0

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Délai: Month 6

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Délai: Year 1

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Délai: Year 2

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Délai: Year 5

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Délai: Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Délai: Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Délai: Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Délai: Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Délai: Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the quadriceps muscles at 180°/s.
Délai: Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Day 0
Endurance coefficient of the quadriceps muscles at 180°/s.
Délai: Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Month 6
Endurance coefficient of the quadriceps muscles at 180°/s.
Délai: Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 1
Endurance coefficient of the quadriceps muscles at 180°/s.
Délai: Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 2
Endurance coefficient of the quadriceps muscles at 180°/s.
Délai: Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the hamstring muscles at 180°/s.
Délai: Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Day 0
Endurance coefficient of the hamstring muscles at 180°/s.
Délai: Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Month 6
Endurance coefficient of the hamstring muscles at 180°/s.
Délai: Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 1
Endurance coefficient of the hamstring muscles at 180°/s.
Délai: Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 2
Endurance coefficient of the hamstring muscles at 180°/s.
Délai: Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 5
Functional ratio
Délai: Day 0

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Day 0
Functional ratio
Délai: Month 6

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Month 6
Functional ratio
Délai: Year 1

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 1
Functional ratio
Délai: Year 2

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 2
Functional ratio
Délai: Year 5

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 5
Mixed ratio
Délai: Day 0

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Day 0
Mixed ratio
Délai: Month 6

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Month 6
Mixed ratio
Délai: Year 1

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 1
Mixed ratio
Délai: Year 2

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 2
Mixed ratio
Délai: Year 5

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 5
Maximum voluntary hand grip strength (Kg).
Délai: Day 0

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Day 0
Maximum voluntary hand grip strength (Kg).
Délai: Month 6

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Month 6
Maximum voluntary hand grip strength (Kg).
Délai: Year 1

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 1
Maximum voluntary hand grip strength (Kg).
Délai: Year 2

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 2
Maximum voluntary hand grip strength (Kg).
Délai: Year 5

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 5
Maximum voluntary pinch strength (Kg).
Délai: Day 0

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Day 0
Maximum voluntary pinch strength (Kg).
Délai: Month 6

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Month 6
Maximum voluntary pinch strength (Kg).
Délai: Year 1

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 1
Maximum voluntary pinch strength (Kg).
Délai: Year 2

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 2
Maximum voluntary pinch strength (Kg).
Délai: Year 5

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 5
Hip passive joint range
Délai: Day 0

Hip joint range will be measured with a medical goniometer.
Day 0
Hip passive joint range
Délai: Month 6

Hip joint range will be measured with a medical goniometer.
Month 6
Hip passive joint range
Délai: Year 1

Hip joint range will be measured with a medical goniometer.
Year 1
Hip passive joint range
Délai: Year 2

Hip joint range will be measured with a medical goniometer.
Year 2
Hip passive joint range
Délai: Year 5

Hip joint range will be measured with a medical goniometer.
Year 5
Knee passive joint range.
Délai: Day 0

Knee joint range will be measured with a medical goniometer.
Day 0
Knee passive joint range.
Délai: Month 6

Knee joint range will be measured with a medical goniometer.
Month 6
Knee passive joint range.
Délai: Year 1

Knee joint range will be measured with a medical goniometer.
Year 1
Knee passive joint range.
Délai: Year 2

Knee joint range will be measured with a medical goniometer.
Year 2
Knee passive joint range.
Délai: Year 5

Knee joint range will be measured with a medical goniometer.
Year 5
Ankle passive joint range
Délai: Day 0

Ankle joint range will be measured with a medical goniometer.
Day 0
Ankle passive joint range
Délai: Month 6

Ankle joint range will be measured with a medical goniometer.
Month 6
Ankle passive joint range
Délai: Year 1

Ankle joint range will be measured with a medical goniometer.
Year 1
Ankle passive joint range
Délai: Year 2

Ankle joint range will be measured with a medical goniometer.
Year 2
Ankle passive joint range
Délai: Year 5

Ankle joint range will be measured with a medical goniometer.
Year 5
Lower and upper limb muscle power assessment (MRC)
Délai: Day 0

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Day 0
Lower and upper limb muscle power assessment (MRC)
Délai: Month 6

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Month 6
Lower and upper limb muscle power assessment (MRC)
Délai: Year 1

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 1
Lower and upper limb muscle power assessment (MRC)
Délai: Year 2

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 2
Lower and upper limb muscle power assessment (MRC)
Délai: Year 5

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 5
Statokinesigram surface area (mm²)
Délai: Day 0

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Day 0
Statokinesigram surface area (mm²)
Délai: Month 6

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Month 6
Statokinesigram surface area (mm²)
Délai: Year 1

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 1
Statokinesigram surface area (mm²)
Délai: Year 2

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 2
Statokinesigram surface area (mm²)
Délai: Year 5

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 5
Stabilogram length (mm).
Délai: Day 0

Stabilogram length will be measured with the STATIPRO® static posturography platform
Day 0
Stabilogram length (mm).
Délai: Month 6

Stabilogram length will be measured with the STATIPRO® static posturography platform
Month 6
Stabilogram length (mm).
Délai: Year 1

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 1
Stabilogram length (mm).
Délai: Year 2

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 2
Stabilogram length (mm).
Délai: Year 5

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 5
Maximal deflection (forward, backward left and right).
Délai: Day 0

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Day 0
Maximal deflection (forward, backward left and right).
Délai: Month 6

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Month 6
Maximal deflection (forward, backward left and right).
Délai: Year 1

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 1
Maximal deflection (forward, backward left and right).
Délai: Year 2

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 2
Maximal deflection (forward, backward left and right).
Délai: Year 5

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 5
Velocity variations (mm/s).
Délai: Day 0

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Day 0
Velocity variations (mm/s).
Délai: Month 6

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Month 6
Velocity variations (mm/s).
Délai: Year 1

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 1
Velocity variations (mm/s).
Délai: Year 2

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 2
Velocity variations (mm/s).
Délai: Year 5

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 5
: Romberg ratio according to sway area
Délai: Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
: Romberg ratio according to sway area
Délai: Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
: Romberg ratio according to sway area
Délai: Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
: Romberg ratio according to sway area
Délai: Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
: Romberg ratio according to sway area
Délai: Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
Romberg ratio according to center of pressure path length
Délai: Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
Romberg ratio according to center of pressure path length
Délai: Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
Romberg ratio according to center of pressure path length
Délai: Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
Romberg ratio according to center of pressure path length
Délai: Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
Romberg ratio according to center of pressure path length
Délai: Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
: Plantar pressure ratio sway area.
Délai: Day 0

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Day 0
: Plantar pressure ratio sway area.
Délai: Month 6

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Month 6
: Plantar pressure ratio sway area.
Délai: Year 1

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 1
: Plantar pressure ratio sway area.
Délai: Year 2

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 2
: Plantar pressure ratio sway area.
Délai: Year 5

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 5
Plantar pressure ratio length.
Délai: Day 0

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Day 0
Plantar pressure ratio length.
Délai: Month 6

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Month 6
Plantar pressure ratio length.
Délai: Year 1

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 1
Plantar pressure ratio length.
Délai: Year 2

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 2
Plantar pressure ratio length.
Délai: Year 5

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 5
Walking velocity (cm/s).
Délai: Day 0

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Day 0
Walking velocity (cm/s).
Délai: Month 6

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Month 6
Walking velocity (cm/s).
Délai: Year 1

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 1
Walking velocity (cm/s).
Délai: Year 2

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 2
Walking velocity (cm/s).
Délai: Year 5

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 5
Cadence (steps/min).
Délai: Day 0

: Cadence will be measured with the GAITRite® Electronic Walkway.
Day 0
Cadence (steps/min).
Délai: Month 6

: Cadence will be measured with the GAITRite® Electronic Walkway.
Month 6
Cadence (steps/min).
Délai: Year 1

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 1
Cadence (steps/min).
Délai: Year 2

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 2
Cadence (steps/min).
Délai: Year 5

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 5
Step length (left and right foot) (cm)
Délai: DAy 0

Step length will be measured with the GAITRite® Electronic Walkway.
DAy 0
Step length (left and right foot) (cm)
Délai: Month 6

Step length will be measured with the GAITRite® Electronic Walkway.
Month 6
Step length (left and right foot) (cm)
Délai: Year 1

Step length will be measured with the GAITRite® Electronic Walkway.
Year 1
Step length (left and right foot) (cm)
Délai: Year 2

Step length will be measured with the GAITRite® Electronic Walkway.
Year 2
Step length (left and right foot) (cm)
Délai: Year 5

Step length will be measured with the GAITRite® Electronic Walkway.
Year 5
Stride length (cm).
Délai: Day 0

Stride length will be measured with the GAITRite® Electronic Walkway.
Day 0
Stride length (cm).
Délai: month 6

Stride length will be measured with the GAITRite® Electronic Walkway.
month 6
Stride length (cm).
Délai: year 1

Stride length will be measured with the GAITRite® Electronic Walkway.
year 1
Stride length (cm).
Délai: year 2

Stride length will be measured with the GAITRite® Electronic Walkway.
year 2
Stride length (cm).
Délai: year 5

Stride length will be measured with the GAITRite® Electronic Walkway.
year 5
Single support time left and right foot (s).
Délai: Day 0

Single support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Single support time left and right foot (s).
Délai: Month 6

Single support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Single support time left and right foot (s).
Délai: Year 1

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 1
Single support time left and right foot (s).
Délai: Year 2

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Single support time left and right foot (s).
Délai: Year 5

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Double support time (s).
Délai: Day 0

: Double support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Double support time (s).
Délai: Month 6

: Double support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Double support time (s).
Délai: YEar 1

: Double support time will be measured with the GAITRite® Electronic Walkway.
YEar 1
Double support time (s).
Délai: Year 2

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Double support time (s).
Délai: Year 5

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing time (s).
Délai: Day 0

: Swing time will be measured with the GAITRite® Electronic Walkway.
Day 0
Swing time (s).
Délai: Month 6

: Swing time will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing time (s).
Délai: Year 1

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing time (s).
Délai: Year 2

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing time (s).
Délai: Year 5

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing phase (as a % of walking cycle).
Délai: DAy 0

: Swing phase will be measured with the GAITRite® Electronic Walkway.
DAy 0
Swing phase (as a % of walking cycle).
Délai: Month 6

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing phase (as a % of walking cycle).
Délai: Year 1

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing phase (as a % of walking cycle).
Délai: Year 2

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing phase (as a % of walking cycle).
Délai: Year 5

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Stance phase (as a % of walking cycle).
Délai: Day 0

Stance phase will be measured with the GAITRite® Electronic Walkway.
Day 0
Stance phase (as a % of walking cycle).
Délai: Month 6

Stance phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Stance phase (as a % of walking cycle).
Délai: Year 1

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Stance phase (as a % of walking cycle).
Délai: Year 2

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Stance phase (as a % of walking cycle).
Délai: Year 5

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Délai: Day 0

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Délai: Month 6

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Délai: Year 1

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Délai: Year 2

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Délai: Year 5

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum heart rate (bpm).
Délai: Day 0

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum heart rate (bpm).
Délai: Month 6

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum heart rate (bpm).
Délai: Year 1

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum heart rate (bpm).
Délai: Year 2

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum heart rate (bpm).
Délai: Year 5

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum power (Watts).
Délai: Day 0

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum power (Watts).
Délai: Month 6

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum power (Watts).
Délai: Year 1

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum power (Watts).
Délai: Year 2

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum power (Watts).
Délai: Year 5

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold power (Watts).
Délai: Day 0

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Threshold power (Watts).
Délai: Month 6

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold power (Watts).
Délai: Year 1

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold power (Watts).
Délai: Year 2

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold power (Watts).
Délai: Year 5

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold heart rate (bpm).
Délai: DAy 0

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
DAy 0
Threshold heart rate (bpm).
Délai: Month 6

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold heart rate (bpm).
Délai: Year 1

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold heart rate (bpm).
Délai: Year 2

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold heart rate (bpm).
Délai: Year 5

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Forced vital Capacity (L).
Délai: Day 0

: Forced vital Capacity will be measured with a spirometry test.
Day 0
Forced vital Capacity (L).
Délai: Month 6

: Forced vital Capacity will be measured with a spirometry test.
Month 6
Forced vital Capacity (L).
Délai: Year 1

: Forced vital Capacity will be measured with a spirometry test.
Year 1
Forced vital Capacity (L).
Délai: Year 2

: Forced vital Capacity will be measured with a spirometry test.
Year 2
Forced vital Capacity (L).
Délai: Year 5

: Forced vital Capacity will be measured with a spirometry test.
Year 5
Forced Expiratory volume (L)
Délai: Day 0

Forced Expiratory volume will be measured with a spirometry test.
Day 0
Forced Expiratory volume (L)
Délai: Month 6

Forced Expiratory volume will be measured with a spirometry test.
Month 6
Forced Expiratory volume (L)
Délai: Year 1

Forced Expiratory volume will be measured with a spirometry test.
Year 1
Forced Expiratory volume (L)
Délai: Year 2

Forced Expiratory volume will be measured with a spirometry test.
Year 2
Forced Expiratory volume (L)
Délai: Year 5

Forced Expiratory volume will be measured with a spirometry test.
Year 5
Tiffeneau ratio (%).
Délai: Day 0

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Day 0
Tiffeneau ratio (%).
Délai: Month 6

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Month 6
Tiffeneau ratio (%).
Délai: Year 1

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 1
Tiffeneau ratio (%).
Délai: Year 2

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 2
Tiffeneau ratio (%).
Délai: Year 5

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 5
Ventilatory reserve (%).
Délai: Day 0

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Ventilatory reserve (%).
Délai: Month 6

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Ventilatory reserve (%).
Délai: Year 1

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Ventilatory reserve (%).
Délai: Year 2

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Ventilatory reserve (%).
Délai: Year 5

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Physical activity
Délai: Day 0

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Day 0
Physical activity
Délai: Month 6

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Month 6
Physical activity
Délai: Year 1

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 1
Physical activity
Délai: Year 2

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 2
Physical activity
Délai: Year 5

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 5
Functional capacity timed-up and go
Délai: Day 0

Functional capacity will be evaluated using the Timed-Up and Go test.
Day 0
Functional capacity timed-up and go
Délai: Month 6

Functional capacity will be evaluated using the Timed-Up and Go test.
Month 6
Functional capacity timed-up and go
Délai: Year 1

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 1
Functional capacity timed-up and go
Délai: Year 2

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 2
Functional capacity timed-up and go
Délai: Year 5

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 5
Functional capacity TDM6
Délai: Day 0

Functional capacity will be evaluated using the 6-minute walk test.
Day 0
Functional capacity TDM6
Délai: Month 6

Functional capacity will be evaluated using the 6-minute walk test.
Month 6
Functional capacity TDM6
Délai: Year 1

Functional capacity will be evaluated using the 6-minute walk test.
Year 1
Functional capacity TDM6
Délai: Year 2

Functional capacity will be evaluated using the 6-minute walk test.
Year 2
Functional capacity TDM6
Délai: Year 5

Functional capacity will be evaluated using the 6-minute walk test.
Year 5
Functional capacity Five Times Sit to Stand test.
Délai: Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Day 0
Functional capacity Five Times Sit to Stand test.
Délai: Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Month 6
Functional capacity Five Times Sit to Stand test.
Délai: Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 1
Functional capacity Five Times Sit to Stand test.
Délai: Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 2
Functional capacity Five Times Sit to Stand test.
Délai: Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 5
Functional capacity SPPB
Délai: Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Day 0
Functional capacity SPPB
Délai: Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Month 6
Functional capacity SPPB
Délai: Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 1
Functional capacity SPPB
Délai: Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 2
Functional capacity SPPB
Délai: Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 5
Functional capacity the mini-BESTest.
Délai: Day 0

Functional capacity will be evaluated using the mini-BESTest.
Day 0
Functional capacity the mini-BESTest.
Délai: Month 6

Functional capacity will be evaluated using the mini-BESTest.
Month 6
Functional capacity the mini-BESTest.
Délai: Year 1

Functional capacity will be evaluated using the mini-BESTest.
Year 1
Functional capacity the mini-BESTest.
Délai: Year 2

Functional capacity will be evaluated using the mini-BESTest.
Year 2
Functional capacity the mini-BESTest.
Délai: Year 5

Functional capacity will be evaluated using the mini-BESTest.
Year 5
Functional capacity Berg Balance Scale.
Délai: Day 0

Functional capacity will be evaluated using the Berg Balance Scale.
Day 0
Functional capacity Berg Balance Scale.
Délai: Month 6

Functional capacity will be evaluated using the Berg Balance Scale.
Month 6
Functional capacity Berg Balance Scale.
Délai: Year 1

Functional capacity will be evaluated using the Berg Balance Scale.
Year 1
Functional capacity Berg Balance Scale.
Délai: Year 2

Functional capacity will be evaluated using the Berg Balance Scale.
Year 2
Functional capacity Berg Balance Scale.
Délai: Year 5

Functional capacity will be evaluated using the Berg Balance Scale.
Year 5
Functional capacity 10-meter walk test
Délai: Day 0

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Day 0
Functional capacity 10-meter walk test
Délai: Month 6

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Month 6
Functional capacity 10-meter walk test
Délai: Year 1

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 1
Functional capacity 10-meter walk test
Délai: Year 2

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 2
Functional capacity 10-meter walk test
Délai: Year 5

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 5
Dyspnea
Délai: Day 0

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Day 0
Dyspnea
Délai: Month 6

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Dyspnea
Délai: Year 1

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Dyspnea
Délai: Year 2

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Dyspnea
Délai: Year 5

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Perceived exertion before, during and after effort
Délai: DAy 0

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
DAy 0
Perceived exertion before, during and after effort
Délai: Month 6

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Perceived exertion before, during and after effort
Délai: Year 1

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Perceived exertion before, during and after effort
Délai: Year 2

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Perceived exertion before, during and after effort
Délai: Year 5

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Musculoskeletal Pain
Délai: Day 0

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Day 0
Musculoskeletal Pain
Délai: Month 6

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Month 6
Musculoskeletal Pain
Délai: Year 1

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 1
Musculoskeletal Pain
Délai: Year 2

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 2
Musculoskeletal Pain
Délai: Year 5

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 5
Sarcopenia risk
Délai: Day 0

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Day 0
Sarcopenia risk
Délai: Month 6

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Month 6
Sarcopenia risk
Délai: Year 1

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 1
Sarcopenia risk
Délai: Year 2

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 2
Sarcopenia risk
Délai: Year 5

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 5
Social insecurity
Délai: Day 0

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Day 0
Social insecurity
Délai: Month 6

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Month 6
Social insecurity
Délai: Year 1

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 1
Social insecurity
Délai: Year 2

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 2
Social insecurity
Délai: Year 5

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 5
Kinesiophobia
Délai: Day 0

Kinesiophobia will be evaluated with the TAMPA Scale.
Day 0
Kinesiophobia
Délai: Month 6

Kinesiophobia will be evaluated with the TAMPA Scale.
Month 6
Kinesiophobia
Délai: Year 1

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 1
Kinesiophobia
Délai: Year 2

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 2
Kinesiophobia
Délai: Year 5

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 5
Quality of life
Délai: Day 0

Quality of life will be evaluated with the 36-Item Short Form Survey.
Day 0
Quality of life
Délai: Month 6

Quality of life will be evaluated with the 36-Item Short Form Survey.
Month 6
Quality of life
Délai: Year 1

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 1
Quality of life
Délai: Year 2

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 2
Quality of life
Délai: Year 5

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 5
: Balance confidence in performing various activities
Délai: Day 0

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Day 0
: Balance confidence in performing various activities
Délai: Month 6

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Month 6
: Balance confidence in performing various activities
Délai: Year 1

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 1
: Balance confidence in performing various activities
Délai: Year 2

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 2
: Balance confidence in performing various activities
Délai: Year 5

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 5
Functioning in regards to activities of daily living.
Délai: Day 0

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Day 0
Functioning in regards to activities of daily living.
Délai: Month 6

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Month 6
Functioning in regards to activities of daily living.
Délai: Year 1

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 1
Functioning in regards to activities of daily living.
Délai: Year 2

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 2
Functioning in regards to activities of daily living.
Délai: Year 5

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 5
Exhaustion
Délai: Day 0

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Day 0
Exhaustion
Délai: Month 6

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Month 6
Exhaustion
Délai: Year 1

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 1
Exhaustion
Délai: Year 2

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 2
Exhaustion
Délai: Year 5

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 5
Patient's opinion about their knee and associated problems
Délai: Day 0

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Day 0
Patient's opinion about their knee and associated problems
Délai: Month 6

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Month 6
Patient's opinion about their knee and associated problems
Délai: Year 1

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 1
Patient's opinion about their knee and associated problems
Délai: Year 2

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 2
Patient's opinion about their knee and associated problems
Délai: Year 5

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 5
Patient's opinion about their hip and associated problems
Délai: Day 0

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Day 0
Patient's opinion about their hip and associated problems
Délai: Month 6

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Month 6
Patient's opinion about their hip and associated problems
Délai: Year 1

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 1
Patient's opinion about their hip and associated problems
Délai: Year 2

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 2
Patient's opinion about their hip and associated problems
Délai: Year 5

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 5
Predicting discharge destination after total joint arthroplasty.
Délai: Day 0

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Day 0
Predicting discharge destination after total joint arthroplasty.
Délai: Month 6

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Month 6
Physical function in myositis patients
Délai: Day 0

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Day 0
Physical function in myositis patients
Délai: Month 6

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Month 6
Physical function in myositis patients
Délai: Year 1

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 1
Physical function in myositis patients
Délai: Year 2

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 2
Physical function in myositis patients
Délai: Year 5

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 5
Quality of life in Parkinson's Disease
Délai: Day 0

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Day 0
Quality of life in Parkinson's Disease
Délai: Month 6

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Month 6
Quality of life in Parkinson's Disease
Délai: Year 1

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 1
Quality of life in Parkinson's Disease
Délai: Year 2

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 2
Quality of life in Parkinson's Disease
Délai: Year 5

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 5
Actimetry.
Délai: during 5 consecutive days after day 0

Actimetry data (energy expenditure, number of steps, sedentary time, total physical activity, etc.) will be obtained with the WGT3X-BT Actigraph inertial sensor unit.
during 5 consecutive days after day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Délai: Day 0

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Délai: Month 6

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Délai: Year 1

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Délai: Year 2

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Délai: Year 5

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Délai: Day 0

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Délai: Month 6

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Délai: Year 1

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Délai: Year 2

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Délai: Year 5

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Délai: Day 0

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Délai: Month 6

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Délai: Year 1

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Délai: Year 2

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Délai: Year 5

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Délai: Day 0

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Délai: Month 6

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Délai: Year 1

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Délai: Year 2

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Délai: Year 5

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Délai: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Délai: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Délai: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Parrainer

University Hospital, Clermont-Ferrand

Collaborateurs

I-SITE Cap 20-25 project

Les enquêteurs

  • Chercheur principal: Frédéric Costes, University Hospital, Clermont-Ferrand

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude (Réel)

27 août 2020

Achèvement primaire (Estimé)

26 août 2035

Achèvement de l'étude (Estimé)

26 août 2035

Dates d'inscription aux études

Première soumission

27 avril 2020

Première soumission répondant aux critères de contrôle qualité

4 mai 2020

Première publication (Réel)

5 mai 2020

Mises à jour des dossiers d'étude

Dernière mise à jour publiée (Réel)

4 novembre 2026

Dernière mise à jour soumise répondant aux critères de contrôle qualité

2 novembre 2026

Dernière vérification

1 octobre 2026

Plus d'information

Termes liés à cette étude

Mots clés

Termes MeSH pertinents supplémentaires

Autres numéros d'identification d'étude

  • RBHP 2019 COSTES
  • 2019-A01017-50 (Autre identifiant: 2019-A01017-50)

Informations sur les médicaments et les dispositifs, documents d'étude

Étudie un produit pharmaceutique réglementé par la FDA américaine

Non

Étudie un produit d'appareil réglementé par la FDA américaine

Non

Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .

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