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コホートの慢性疾患構成における機動性障害の評価 (EVALMOB)

2026年11月2日 更新者：University Hospital, Clermont-Ferrand

Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge both for the treatment of causal pathologies, as well as for evaluating the impact of therapeutic interventions, the benefit of which will be an improvement in physical capacities and ultimately mobility. In view of the hypothesis of an increase in the prevalence of mobility disorders in this population, this approach is part of a logic of screening and improving the effectiveness of the care of these patients with a multidisciplinary evaluation of individual risks. The EVALMOB protocol was designed in order to try to determine a standard profile of "dysmobility" in patients with chronic illness

調査の概要

状態

募集

条件

介入・治療

詳細な説明

We propose to constitute a prospective cohort of subjects carrying chronic disease. The objective is to explore all the different components of mobility (balance, muscle force, body composition, walking ability, metabolism, etc.), to assess their impact on the functional capacity of individuals and to identify their potential interactions. Processing this data could ultimately allow the development of a model to determine a composite standard profile of "dysmobility" in patients with chronic disease.

In the present protocol, parameters will be measured on five occasions (at inclusion, at 6 months from the inclusion day, at 1,2 and 5 year(s) from the inclusion day). All tests will be performed on the same day. New assessments will be done on the same principle as the initial evaluation.

Statistical analyses will be carried out using Stata software (version 13, StataCorp, College Station, USA). Data will be described by frequencies and percentages for categorical variables and by means and standard deviation (or median and interquartile range if data are not normally distributed) for continuous variables. The normality of continuous data will be assessed graphically and using the Shapiro-Wilk test. The main analysis will consist in determining patient profiles regarding their mobility. Clustering-type approaches (supervised or not) will be proposed: k-means, vector machine support, machine learning, factor analysis. For example, factor analyses on mixed data will allow the main components of mobility to be characterized. They can be followed by an ascending hierarchical classification in order to determine homogeneous groups of patients.

These groups will be described and compared on the main criteria evaluated using standard statistical tests: chi2 test (or Fisher's exact test if applicable) for the categorical criteria and using an analysis of variance (or Kruskal-Wallis if data are not normally distributed) for continuous criteria. The main analysis will be broken down more specifically for each of the pathologies considered. In addition, the sensitivity to change will be assessed in each pathology and for each assessment criterion. The search for factors related to the evolution of the different criteria will be carried out using usual tests and mixed multivariate models (logistics for categorical / linear criteria for continuous criteria) considering the subject as a random effect, and adjusting on the time criteria (inclusion / follow-up) and the criteria highlighted in the univariate analyses and in light of the elements reported in the literature. A sensitivity analysis will be proposed in order to study the statistical nature of the missing data and to propose, if necessary, the most suitable method of imputing the data: multiple imputation, maximum bias or LOCF in the case of longitudinal data.

研究の種類

介入

入学 (推定)

5000

段階

  • 適用できない

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究連絡先

研究場所

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

18年～90年 (大人、高齢者)

健康ボランティアの受け入れ

いいえ

受講資格のある性別

全て

説明

Inclusion Criteria:

  • Man or woman aged 18 to 90.
  • Patients with chronic pathology contributing to impaired mobility.
  • Volunteers who have given their written consent.
  • Affiliated to French health care system (for France)

Exclusion Criteria:

  • Patients suffering from progressive psychiatric pathologies (active psychosis, hallucinations, etc.) or the presence of another serious unstabilized pathology (decompensated heart failure, progressive terminal cancer, etc.).
  • People with poorly controlled or unstable cardiovascular disease.
  • Major osteoarticular or neurological problems completely preventing the proper performance of the various tests.
  • Non-autonomous patient
  • Persons under guardianship, curatorship, deprived of liberty or safeguarding justice.
  • People excluded from another study.
  • Pregnant or lactating women.

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか？

デザインの詳細

  • 主な目的：診断
  • 割り当て：なし
  • 介入モデル：単一グループの割り当て
  • マスキング：なし（オープンラベル）

武器と介入

参加者グループ / アーム
介入・治療
実験的：Cohort 1

Participants will be involved in a long-term evaluation program combining, body composition measures, physical tests as well as self-administered questionnaires. Participants will be followed for 5 years with evaluations taking place at inclusion, 6 months, at 1, 2 and 5 years
他の：Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.

Firstly, volunteers will be invited to complete online questionnaires on a secure platform. The mobility assessment will be carried out initially (t1) and up to a maximum of 4 times (t1 to t4) as part of a day hospitalization. Questionnaires will be diverse (SF36, KOOS, HOOS, BROCKER, MNA, TAMPA, etc.) in order to assess several aspects that compose mobility.

Physical evaluations will include various validated tests (isokinetic strength measure, TUG, 6MWT, Berg Balance Scale, etc.)

この研究は何を測定していますか？

主要な結果の測定

結果測定
メジャーの説明
時間枠
dismobility score calculated from the results reported in secondary outcomes
時間枠：Day 0

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Day 0
dismobility score calculated from the results reported in secondary outcomes
時間枠：Month 6

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Month 6
dismobility score calculated from the results reported in secondary outcomes
時間枠：Year 1

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 1
dismobility score calculated from the results reported in secondary outcomes
時間枠：Year 2

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 2
dismobility score calculated from the results reported in secondary outcomes
時間枠：Year 5

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 5

二次結果の測定

結果測定
メジャーの説明
時間枠
The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
時間枠：Day 0

Demographics information will be obtained using a single questionnaire including questions on age, gender, qualification, personal work status, ethnicity, life and occupational events.
Day 0
Weight (Kg).
時間枠：Day 0

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Day 0
Weight (Kg).
時間枠：Month 6

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Month 6
Weight (Kg).
時間枠：Year 1

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 1
Weight (Kg).
時間枠：Year 2

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 2
Weight (Kg).
時間枠：Year 5

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 5
Height (cm).
時間枠：Day 0

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Day 0
Height (cm).
時間枠：Month 6

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Month 6
Height (cm).
時間枠：Year 1

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 1
Height (cm).
時間枠：Year 2

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 2
Height (cm).
時間枠：Year 5

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 5
Body fat percentage (%).
時間枠：Day 0

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Day 0
Body fat percentage (%).
時間枠：Month 6

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Month 6
Body fat percentage (%).
時間枠：Year 1

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 1
Body fat percentage (%).
時間枠：Year 2

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 2
Body fat percentage (%).
時間枠：Year 5

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 5
Waist circumference (cm).
時間枠：Day 0

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Waist circumference (cm).
時間枠：Month 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 5
Waist circumference (cm).
時間枠：Year 1

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Waist circumference (cm).
時間枠：Year 2

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Waist circumference (cm).
時間枠：Year 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Hip circumference (cm).
時間枠：Day 0

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Hip circumference (cm).
時間枠：Month 6

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Hip circumference (cm).
時間枠：Year 1

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Hip circumference (cm).
時間枠：Year 2

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Hip circumference (cm).
時間枠：Year 5

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Brachial circumference (cm).
時間枠：Day 0

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Brachial circumference (cm).
時間枠：Month 6

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Brachial circumference (cm).
時間枠：Year 1

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Brachial circumference (cm).
時間枠：Year 2

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Brachial circumference (cm).
時間枠：Year 5

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Calf circumference (cm).
時間枠：Day 0

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Calf circumference (cm).
時間枠：Month 6

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 6
Calf circumference (cm).
時間枠：Year 1

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Calf circumference (cm).
時間枠：Year 2

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Calf circumference (cm).
時間枠：Year 5

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Body Mass Index (Kg/m²).
時間枠：Day 0

BMI will be calculated (weight in kilograms divided by height in meters squared).
Day 0
Body Mass Index (Kg/m²).
時間枠：Month 6

BMI will be calculated (weight in kilograms divided by height in meters squared).
Month 6
Body Mass Index (Kg/m²).
時間枠：Year 1

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 1
Body Mass Index (Kg/m²).
時間枠：Year 2

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 2
Body Mass Index (Kg/m²).
時間枠：Year 5

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 5
Body composition
時間枠：Day 0

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Day 0
Body composition
時間枠：Month 6

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Month 6
Body composition
時間枠：Year 1

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 1
Body composition
時間枠：Year 2

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 2
Body composition
時間枠：Year 5

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 5
T-score (DS).
時間枠：DAy 0

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
DAy 0
T-score (DS).
時間枠：Month 6

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
T-score (DS).
時間枠：Year 1

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
T-score (DS).
時間枠：Year 2

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
T-score (DS).
時間枠：Year 5

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Z-score (DS).
時間枠：Day 0

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Z-score (DS).
時間枠：Month 6

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Z-score (DS).
時間枠：Year 1

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Z-score (DS).
時間枠：Year 2

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Z-score (DS).
時間枠：Year 5

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Fat mass
時間枠：Day 0

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mass
時間枠：Month 6

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mass
時間枠：Year 1

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mass
時間枠：Year 2

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mass
時間枠：Year 5

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass (%).
時間枠：Day 0

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass (%).
時間枠：Month 6

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass (%).
時間枠：Year 1

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass (%).
時間枠：Year 2

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass (%).
時間枠：Year 5

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat mas index (Kg/m²).
時間枠：Day 0

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mas index (Kg/m²).
時間枠：Month 6

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mas index (Kg/m²).
時間枠：Year 1

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mas index (Kg/m²).
時間枠：Year 2

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mas index (Kg/m²).
時間枠：Year 5

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Ratio of android to gynoid fat mass.
時間枠：Day 0

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Ratio of android to gynoid fat mass.
時間枠：Month 6

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Ratio of android to gynoid fat mass.
時間枠：Year 1

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Ratio of android to gynoid fat mass.
時間枠：Year 2

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Ratio of android to gynoid fat mass.
時間枠：Year 5

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Visceral adipose tissue (Kg).
時間枠：Day 0

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Visceral adipose tissue (Kg).
時間枠：Month 6

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Visceral adipose tissue (Kg).
時間枠：Year 1

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Visceral adipose tissue (Kg).
時間枠：Year 2

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Visceral adipose tissue (Kg).
時間枠：Year 5

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass index (kg/m²).
時間枠：Day 0

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass index (kg/m²).
時間枠：Month 6

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass index (kg/m²).
時間枠：Year 1

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass index (kg/m²).
時間枠：Year 2

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass index (kg/m²).
時間枠：Year 5

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Appendicular fat-free mass index (Kg/m²).
時間枠：Day 0

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Appendicular fat-free mass index (Kg/m²).
時間枠：Month 6

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Appendicular fat-free mass index (Kg/m²).
時間枠：Year 1

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Appendicular fat-free mass index (Kg/m²).
時間枠：Year 2

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Appendicular fat-free mass index (Kg/m²).
時間枠：Year 5

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Bone mass (Kg)
時間枠：Day 0

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Bone mass (Kg)
時間枠：Month 6

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Bone mass (Kg)
時間枠：Year 1

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Bone mass (Kg)
時間枠：Year 2

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Bone mass (Kg)
時間枠：Year 5

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Daily caloric intake (Kcal/24h).
時間枠：Day 0

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily caloric intake (Kcal/24h).
時間枠：Month 6

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily caloric intake (Kcal/24h).
時間枠：Year 1

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily caloric intake (Kcal/24h).
時間枠：Year 2

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily caloric intake (Kcal/24h).
時間枠：Year 5

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily protein intake (in g and as a percentage of total caloric intake).
時間枠：Day 0

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily protein intake (in g and as a percentage of total caloric intake).
時間枠：Month 6

Daily protein intake (in g and as a percentage of total caloric intake).
Month 6
Daily protein intake (in g and as a percentage of total caloric intake).
時間枠：Year 1

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily protein intake (in g and as a percentage of total caloric intake).
時間枠：Year 2

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily protein intake (in g and as a percentage of total caloric intake).
時間枠：Year 5

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
時間枠：Day 0

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
時間枠：Month 6

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
時間枠：Year 1

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
時間枠：Year 2

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
時間枠：Year 5

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily fat intake (in g and as a percentage of total caloric intake).
時間枠：Day 0

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily fat intake (in g and as a percentage of total caloric intake).
時間枠：Month 6

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily fat intake (in g and as a percentage of total caloric intake).
時間枠：Year 1

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily fat intake (in g and as a percentage of total caloric intake).
時間枠：Year 2

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily fat intake (in g and as a percentage of total caloric intake).
時間枠：Year 5

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Nutritional status assessment
時間枠：Day 0

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Day 0
Nutritional status assessment
時間枠：Month 6

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Month 6
Nutritional status assessment
時間枠：Year 1

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 1
Nutritional status assessment
時間枠：Year 2

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 2
Nutritional status assessment
時間枠：Year 5

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 5
Risk of undernutrition.
時間枠：Day 0

Risk of undernutrition will be assessed with the Brocker Questionnaire
Day 0
Risk of undernutrition.
時間枠：Month 6

Risk of undernutrition will be assessed with the Brocker Questionnaire
Month 6
Risk of undernutrition.
時間枠：Year 1

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 1
Risk of undernutrition.
時間枠：Year 2

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 2
Risk of undernutrition.
時間枠：Year 5

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 5
Basic biology.
時間枠：Day 0

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Day 0
Basic biology.
時間枠：Month 6

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Month 6
Basic biology.
時間枠：Year 1

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 1
Basic biology.
時間枠：Year 2

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 2
Basic biology.
時間枠：Year 5

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 5
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
時間枠：Day 0

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
時間枠：Month 6

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
時間枠：Year 1

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
時間枠：Year 2

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
時間枠：Year 5

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
時間枠：Day 0

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
時間枠：Month 6

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
時間枠：Year 1

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
時間枠：Year 2

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
時間枠：Year 5

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
時間枠：Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
時間枠：Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
時間枠：Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
時間枠：Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
時間枠：Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
時間枠：Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
時間枠：Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
時間枠：Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
時間枠：Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
時間枠：Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
時間枠：Day 0

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
時間枠：Month 6

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
時間枠：Year 1

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
時間枠：Year 2

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
時間枠：Year 5

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
時間枠：Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the quadriceps muscles at 180°/s.
時間枠：Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Day 0
Endurance coefficient of the quadriceps muscles at 180°/s.
時間枠：Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Month 6
Endurance coefficient of the quadriceps muscles at 180°/s.
時間枠：Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 1
Endurance coefficient of the quadriceps muscles at 180°/s.
時間枠：Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 2
Endurance coefficient of the quadriceps muscles at 180°/s.
時間枠：Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the hamstring muscles at 180°/s.
時間枠：Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Day 0
Endurance coefficient of the hamstring muscles at 180°/s.
時間枠：Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Month 6
Endurance coefficient of the hamstring muscles at 180°/s.
時間枠：Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 1
Endurance coefficient of the hamstring muscles at 180°/s.
時間枠：Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 2
Endurance coefficient of the hamstring muscles at 180°/s.
時間枠：Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 5
Functional ratio
時間枠：Day 0

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Day 0
Functional ratio
時間枠：Month 6

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Month 6
Functional ratio
時間枠：Year 1

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 1
Functional ratio
時間枠：Year 2

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 2
Functional ratio
時間枠：Year 5

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 5
Mixed ratio
時間枠：Day 0

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Day 0
Mixed ratio
時間枠：Month 6

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Month 6
Mixed ratio
時間枠：Year 1

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 1
Mixed ratio
時間枠：Year 2

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 2
Mixed ratio
時間枠：Year 5

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 5
Maximum voluntary hand grip strength (Kg).
時間枠：Day 0

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Day 0
Maximum voluntary hand grip strength (Kg).
時間枠：Month 6

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Month 6
Maximum voluntary hand grip strength (Kg).
時間枠：Year 1

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 1
Maximum voluntary hand grip strength (Kg).
時間枠：Year 2

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 2
Maximum voluntary hand grip strength (Kg).
時間枠：Year 5

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 5
Maximum voluntary pinch strength (Kg).
時間枠：Day 0

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Day 0
Maximum voluntary pinch strength (Kg).
時間枠：Month 6

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Month 6
Maximum voluntary pinch strength (Kg).
時間枠：Year 1

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 1
Maximum voluntary pinch strength (Kg).
時間枠：Year 2

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 2
Maximum voluntary pinch strength (Kg).
時間枠：Year 5

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 5
Hip passive joint range
時間枠：Day 0

Hip joint range will be measured with a medical goniometer.
Day 0
Hip passive joint range
時間枠：Month 6

Hip joint range will be measured with a medical goniometer.
Month 6
Hip passive joint range
時間枠：Year 1

Hip joint range will be measured with a medical goniometer.
Year 1
Hip passive joint range
時間枠：Year 2

Hip joint range will be measured with a medical goniometer.
Year 2
Hip passive joint range
時間枠：Year 5

Hip joint range will be measured with a medical goniometer.
Year 5
Knee passive joint range.
時間枠：Day 0

Knee joint range will be measured with a medical goniometer.
Day 0
Knee passive joint range.
時間枠：Month 6

Knee joint range will be measured with a medical goniometer.
Month 6
Knee passive joint range.
時間枠：Year 1

Knee joint range will be measured with a medical goniometer.
Year 1
Knee passive joint range.
時間枠：Year 2

Knee joint range will be measured with a medical goniometer.
Year 2
Knee passive joint range.
時間枠：Year 5

Knee joint range will be measured with a medical goniometer.
Year 5
Ankle passive joint range
時間枠：Day 0

Ankle joint range will be measured with a medical goniometer.
Day 0
Ankle passive joint range
時間枠：Month 6

Ankle joint range will be measured with a medical goniometer.
Month 6
Ankle passive joint range
時間枠：Year 1

Ankle joint range will be measured with a medical goniometer.
Year 1
Ankle passive joint range
時間枠：Year 2

Ankle joint range will be measured with a medical goniometer.
Year 2
Ankle passive joint range
時間枠：Year 5

Ankle joint range will be measured with a medical goniometer.
Year 5
Lower and upper limb muscle power assessment (MRC)
時間枠：Day 0

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Day 0
Lower and upper limb muscle power assessment (MRC)
時間枠：Month 6

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Month 6
Lower and upper limb muscle power assessment (MRC)
時間枠：Year 1

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 1
Lower and upper limb muscle power assessment (MRC)
時間枠：Year 2

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 2
Lower and upper limb muscle power assessment (MRC)
時間枠：Year 5

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 5
Statokinesigram surface area (mm²)
時間枠：Day 0

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Day 0
Statokinesigram surface area (mm²)
時間枠：Month 6

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Month 6
Statokinesigram surface area (mm²)
時間枠：Year 1

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 1
Statokinesigram surface area (mm²)
時間枠：Year 2

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 2
Statokinesigram surface area (mm²)
時間枠：Year 5

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 5
Stabilogram length (mm).
時間枠：Day 0

Stabilogram length will be measured with the STATIPRO® static posturography platform
Day 0
Stabilogram length (mm).
時間枠：Month 6

Stabilogram length will be measured with the STATIPRO® static posturography platform
Month 6
Stabilogram length (mm).
時間枠：Year 1

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 1
Stabilogram length (mm).
時間枠：Year 2

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 2
Stabilogram length (mm).
時間枠：Year 5

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 5
Maximal deflection (forward, backward left and right).
時間枠：Day 0

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Day 0
Maximal deflection (forward, backward left and right).
時間枠：Month 6

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Month 6
Maximal deflection (forward, backward left and right).
時間枠：Year 1

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 1
Maximal deflection (forward, backward left and right).
時間枠：Year 2

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 2
Maximal deflection (forward, backward left and right).
時間枠：Year 5

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 5
Velocity variations (mm/s).
時間枠：Day 0

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Day 0
Velocity variations (mm/s).
時間枠：Month 6

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Month 6
Velocity variations (mm/s).
時間枠：Year 1

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 1
Velocity variations (mm/s).
時間枠：Year 2

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 2
Velocity variations (mm/s).
時間枠：Year 5

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 5
: Romberg ratio according to sway area
時間枠：Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
: Romberg ratio according to sway area
時間枠：Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
: Romberg ratio according to sway area
時間枠：Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
: Romberg ratio according to sway area
時間枠：Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
: Romberg ratio according to sway area
時間枠：Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
Romberg ratio according to center of pressure path length
時間枠：Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
Romberg ratio according to center of pressure path length
時間枠：Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
Romberg ratio according to center of pressure path length
時間枠：Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
Romberg ratio according to center of pressure path length
時間枠：Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
Romberg ratio according to center of pressure path length
時間枠：Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
: Plantar pressure ratio sway area.
時間枠：Day 0

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Day 0
: Plantar pressure ratio sway area.
時間枠：Month 6

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Month 6
: Plantar pressure ratio sway area.
時間枠：Year 1

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 1
: Plantar pressure ratio sway area.
時間枠：Year 2

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 2
: Plantar pressure ratio sway area.
時間枠：Year 5

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 5
Plantar pressure ratio length.
時間枠：Day 0

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Day 0
Plantar pressure ratio length.
時間枠：Month 6

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Month 6
Plantar pressure ratio length.
時間枠：Year 1

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 1
Plantar pressure ratio length.
時間枠：Year 2

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 2
Plantar pressure ratio length.
時間枠：Year 5

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 5
Walking velocity (cm/s).
時間枠：Day 0

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Day 0
Walking velocity (cm/s).
時間枠：Month 6

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Month 6
Walking velocity (cm/s).
時間枠：Year 1

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 1
Walking velocity (cm/s).
時間枠：Year 2

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 2
Walking velocity (cm/s).
時間枠：Year 5

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 5
Cadence (steps/min).
時間枠：Day 0

: Cadence will be measured with the GAITRite® Electronic Walkway.
Day 0
Cadence (steps/min).
時間枠：Month 6

: Cadence will be measured with the GAITRite® Electronic Walkway.
Month 6
Cadence (steps/min).
時間枠：Year 1

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 1
Cadence (steps/min).
時間枠：Year 2

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 2
Cadence (steps/min).
時間枠：Year 5

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 5
Step length (left and right foot) (cm)
時間枠：DAy 0

Step length will be measured with the GAITRite® Electronic Walkway.
DAy 0
Step length (left and right foot) (cm)
時間枠：Month 6

Step length will be measured with the GAITRite® Electronic Walkway.
Month 6
Step length (left and right foot) (cm)
時間枠：Year 1

Step length will be measured with the GAITRite® Electronic Walkway.
Year 1
Step length (left and right foot) (cm)
時間枠：Year 2

Step length will be measured with the GAITRite® Electronic Walkway.
Year 2
Step length (left and right foot) (cm)
時間枠：Year 5

Step length will be measured with the GAITRite® Electronic Walkway.
Year 5
Stride length (cm).
時間枠：Day 0

Stride length will be measured with the GAITRite® Electronic Walkway.
Day 0
Stride length (cm).
時間枠：month 6

Stride length will be measured with the GAITRite® Electronic Walkway.
month 6
Stride length (cm).
時間枠：year 1

Stride length will be measured with the GAITRite® Electronic Walkway.
year 1
Stride length (cm).
時間枠：year 2

Stride length will be measured with the GAITRite® Electronic Walkway.
year 2
Stride length (cm).
時間枠：year 5

Stride length will be measured with the GAITRite® Electronic Walkway.
year 5
Single support time left and right foot (s).
時間枠：Day 0

Single support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Single support time left and right foot (s).
時間枠：Month 6

Single support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Single support time left and right foot (s).
時間枠：Year 1

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 1
Single support time left and right foot (s).
時間枠：Year 2

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Single support time left and right foot (s).
時間枠：Year 5

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Double support time (s).
時間枠：Day 0

: Double support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Double support time (s).
時間枠：Month 6

: Double support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Double support time (s).
時間枠：YEar 1

: Double support time will be measured with the GAITRite® Electronic Walkway.
YEar 1
Double support time (s).
時間枠：Year 2

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Double support time (s).
時間枠：Year 5

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing time (s).
時間枠：Day 0

: Swing time will be measured with the GAITRite® Electronic Walkway.
Day 0
Swing time (s).
時間枠：Month 6

: Swing time will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing time (s).
時間枠：Year 1

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing time (s).
時間枠：Year 2

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing time (s).
時間枠：Year 5

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing phase (as a % of walking cycle).
時間枠：DAy 0

: Swing phase will be measured with the GAITRite® Electronic Walkway.
DAy 0
Swing phase (as a % of walking cycle).
時間枠：Month 6

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing phase (as a % of walking cycle).
時間枠：Year 1

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing phase (as a % of walking cycle).
時間枠：Year 2

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing phase (as a % of walking cycle).
時間枠：Year 5

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Stance phase (as a % of walking cycle).
時間枠：Day 0

Stance phase will be measured with the GAITRite® Electronic Walkway.
Day 0
Stance phase (as a % of walking cycle).
時間枠：Month 6

Stance phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Stance phase (as a % of walking cycle).
時間枠：Year 1

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Stance phase (as a % of walking cycle).
時間枠：Year 2

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Stance phase (as a % of walking cycle).
時間枠：Year 5

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Vo2max (maximal oxygen consumption) (mL/Kg/min).
時間枠：Day 0

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Vo2max (maximal oxygen consumption) (mL/Kg/min).
時間枠：Month 6

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Vo2max (maximal oxygen consumption) (mL/Kg/min).
時間枠：Year 1

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Vo2max (maximal oxygen consumption) (mL/Kg/min).
時間枠：Year 2

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Vo2max (maximal oxygen consumption) (mL/Kg/min).
時間枠：Year 5

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum heart rate (bpm).
時間枠：Day 0

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum heart rate (bpm).
時間枠：Month 6

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum heart rate (bpm).
時間枠：Year 1

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum heart rate (bpm).
時間枠：Year 2

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum heart rate (bpm).
時間枠：Year 5

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum power (Watts).
時間枠：Day 0

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum power (Watts).
時間枠：Month 6

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum power (Watts).
時間枠：Year 1

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum power (Watts).
時間枠：Year 2

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum power (Watts).
時間枠：Year 5

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold power (Watts).
時間枠：Day 0

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Threshold power (Watts).
時間枠：Month 6

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold power (Watts).
時間枠：Year 1

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold power (Watts).
時間枠：Year 2

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold power (Watts).
時間枠：Year 5

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold heart rate (bpm).
時間枠：DAy 0

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
DAy 0
Threshold heart rate (bpm).
時間枠：Month 6

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold heart rate (bpm).
時間枠：Year 1

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold heart rate (bpm).
時間枠：Year 2

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold heart rate (bpm).
時間枠：Year 5

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Forced vital Capacity (L).
時間枠：Day 0

: Forced vital Capacity will be measured with a spirometry test.
Day 0
Forced vital Capacity (L).
時間枠：Month 6

: Forced vital Capacity will be measured with a spirometry test.
Month 6
Forced vital Capacity (L).
時間枠：Year 1

: Forced vital Capacity will be measured with a spirometry test.
Year 1
Forced vital Capacity (L).
時間枠：Year 2

: Forced vital Capacity will be measured with a spirometry test.
Year 2
Forced vital Capacity (L).
時間枠：Year 5

: Forced vital Capacity will be measured with a spirometry test.
Year 5
Forced Expiratory volume (L)
時間枠：Day 0

Forced Expiratory volume will be measured with a spirometry test.
Day 0
Forced Expiratory volume (L)
時間枠：Month 6

Forced Expiratory volume will be measured with a spirometry test.
Month 6
Forced Expiratory volume (L)
時間枠：Year 1

Forced Expiratory volume will be measured with a spirometry test.
Year 1
Forced Expiratory volume (L)
時間枠：Year 2

Forced Expiratory volume will be measured with a spirometry test.
Year 2
Forced Expiratory volume (L)
時間枠：Year 5

Forced Expiratory volume will be measured with a spirometry test.
Year 5
Tiffeneau ratio (%).
時間枠：Day 0

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Day 0
Tiffeneau ratio (%).
時間枠：Month 6

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Month 6
Tiffeneau ratio (%).
時間枠：Year 1

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 1
Tiffeneau ratio (%).
時間枠：Year 2

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 2
Tiffeneau ratio (%).
時間枠：Year 5

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 5
Ventilatory reserve (%).
時間枠：Day 0

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Ventilatory reserve (%).
時間枠：Month 6

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Ventilatory reserve (%).
時間枠：Year 1

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Ventilatory reserve (%).
時間枠：Year 2

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Ventilatory reserve (%).
時間枠：Year 5

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Physical activity
時間枠：Day 0

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Day 0
Physical activity
時間枠：Month 6

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Month 6
Physical activity
時間枠：Year 1

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 1
Physical activity
時間枠：Year 2

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 2
Physical activity
時間枠：Year 5

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 5
Functional capacity timed-up and go
時間枠：Day 0

Functional capacity will be evaluated using the Timed-Up and Go test.
Day 0
Functional capacity timed-up and go
時間枠：Month 6

Functional capacity will be evaluated using the Timed-Up and Go test.
Month 6
Functional capacity timed-up and go
時間枠：Year 1

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 1
Functional capacity timed-up and go
時間枠：Year 2

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 2
Functional capacity timed-up and go
時間枠：Year 5

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 5
Functional capacity TDM6
時間枠：Day 0

Functional capacity will be evaluated using the 6-minute walk test.
Day 0
Functional capacity TDM6
時間枠：Month 6

Functional capacity will be evaluated using the 6-minute walk test.
Month 6
Functional capacity TDM6
時間枠：Year 1

Functional capacity will be evaluated using the 6-minute walk test.
Year 1
Functional capacity TDM6
時間枠：Year 2

Functional capacity will be evaluated using the 6-minute walk test.
Year 2
Functional capacity TDM6
時間枠：Year 5

Functional capacity will be evaluated using the 6-minute walk test.
Year 5
Functional capacity Five Times Sit to Stand test.
時間枠：Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Day 0
Functional capacity Five Times Sit to Stand test.
時間枠：Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Month 6
Functional capacity Five Times Sit to Stand test.
時間枠：Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 1
Functional capacity Five Times Sit to Stand test.
時間枠：Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 2
Functional capacity Five Times Sit to Stand test.
時間枠：Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 5
Functional capacity SPPB
時間枠：Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Day 0
Functional capacity SPPB
時間枠：Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Month 6
Functional capacity SPPB
時間枠：Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 1
Functional capacity SPPB
時間枠：Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 2
Functional capacity SPPB
時間枠：Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 5
Functional capacity the mini-BESTest.
時間枠：Day 0

Functional capacity will be evaluated using the mini-BESTest.
Day 0
Functional capacity the mini-BESTest.
時間枠：Month 6

Functional capacity will be evaluated using the mini-BESTest.
Month 6
Functional capacity the mini-BESTest.
時間枠：Year 1

Functional capacity will be evaluated using the mini-BESTest.
Year 1
Functional capacity the mini-BESTest.
時間枠：Year 2

Functional capacity will be evaluated using the mini-BESTest.
Year 2
Functional capacity the mini-BESTest.
時間枠：Year 5

Functional capacity will be evaluated using the mini-BESTest.
Year 5
Functional capacity Berg Balance Scale.
時間枠：Day 0

Functional capacity will be evaluated using the Berg Balance Scale.
Day 0
Functional capacity Berg Balance Scale.
時間枠：Month 6

Functional capacity will be evaluated using the Berg Balance Scale.
Month 6
Functional capacity Berg Balance Scale.
時間枠：Year 1

Functional capacity will be evaluated using the Berg Balance Scale.
Year 1
Functional capacity Berg Balance Scale.
時間枠：Year 2

Functional capacity will be evaluated using the Berg Balance Scale.
Year 2
Functional capacity Berg Balance Scale.
時間枠：Year 5

Functional capacity will be evaluated using the Berg Balance Scale.
Year 5
Functional capacity 10-meter walk test
時間枠：Day 0

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Day 0
Functional capacity 10-meter walk test
時間枠：Month 6

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Month 6
Functional capacity 10-meter walk test
時間枠：Year 1

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 1
Functional capacity 10-meter walk test
時間枠：Year 2

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 2
Functional capacity 10-meter walk test
時間枠：Year 5

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 5
Dyspnea
時間枠：Day 0

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Day 0
Dyspnea
時間枠：Month 6

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Dyspnea
時間枠：Year 1

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Dyspnea
時間枠：Year 2

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Dyspnea
時間枠：Year 5

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Perceived exertion before, during and after effort
時間枠：DAy 0

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
DAy 0
Perceived exertion before, during and after effort
時間枠：Month 6

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Perceived exertion before, during and after effort
時間枠：Year 1

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Perceived exertion before, during and after effort
時間枠：Year 2

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Perceived exertion before, during and after effort
時間枠：Year 5

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Musculoskeletal Pain
時間枠：Day 0

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Day 0
Musculoskeletal Pain
時間枠：Month 6

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Month 6
Musculoskeletal Pain
時間枠：Year 1

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 1
Musculoskeletal Pain
時間枠：Year 2

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 2
Musculoskeletal Pain
時間枠：Year 5

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 5
Sarcopenia risk
時間枠：Day 0

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Day 0
Sarcopenia risk
時間枠：Month 6

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Month 6
Sarcopenia risk
時間枠：Year 1

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 1
Sarcopenia risk
時間枠：Year 2

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 2
Sarcopenia risk
時間枠：Year 5

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 5
Social insecurity
時間枠：Day 0

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Day 0
Social insecurity
時間枠：Month 6

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Month 6
Social insecurity
時間枠：Year 1

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 1
Social insecurity
時間枠：Year 2

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 2
Social insecurity
時間枠：Year 5

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 5
Kinesiophobia
時間枠：Day 0

Kinesiophobia will be evaluated with the TAMPA Scale.
Day 0
Kinesiophobia
時間枠：Month 6

Kinesiophobia will be evaluated with the TAMPA Scale.
Month 6
Kinesiophobia
時間枠：Year 1

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 1
Kinesiophobia
時間枠：Year 2

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 2
Kinesiophobia
時間枠：Year 5

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 5
Quality of life
時間枠：Day 0

Quality of life will be evaluated with the 36-Item Short Form Survey.
Day 0
Quality of life
時間枠：Month 6

Quality of life will be evaluated with the 36-Item Short Form Survey.
Month 6
Quality of life
時間枠：Year 1

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 1
Quality of life
時間枠：Year 2

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 2
Quality of life
時間枠：Year 5

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 5
: Balance confidence in performing various activities
時間枠：Day 0

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Day 0
: Balance confidence in performing various activities
時間枠：Month 6

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Month 6
: Balance confidence in performing various activities
時間枠：Year 1

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 1
: Balance confidence in performing various activities
時間枠：Year 2

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 2
: Balance confidence in performing various activities
時間枠：Year 5

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 5
Functioning in regards to activities of daily living.
時間枠：Day 0

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Day 0
Functioning in regards to activities of daily living.
時間枠：Month 6

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Month 6
Functioning in regards to activities of daily living.
時間枠：Year 1

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 1
Functioning in regards to activities of daily living.
時間枠：Year 2

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 2
Functioning in regards to activities of daily living.
時間枠：Year 5

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 5
Exhaustion
時間枠：Day 0

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Day 0
Exhaustion
時間枠：Month 6

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Month 6
Exhaustion
時間枠：Year 1

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 1
Exhaustion
時間枠：Year 2

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 2
Exhaustion
時間枠：Year 5

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 5
Patient's opinion about their knee and associated problems
時間枠：Day 0

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Day 0
Patient's opinion about their knee and associated problems
時間枠：Month 6

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Month 6
Patient's opinion about their knee and associated problems
時間枠：Year 1

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 1
Patient's opinion about their knee and associated problems
時間枠：Year 2

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 2
Patient's opinion about their knee and associated problems
時間枠：Year 5

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 5
Patient's opinion about their hip and associated problems
時間枠：Day 0

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Day 0
Patient's opinion about their hip and associated problems
時間枠：Month 6

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Month 6
Patient's opinion about their hip and associated problems
時間枠：Year 1

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 1
Patient's opinion about their hip and associated problems
時間枠：Year 2

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 2
Patient's opinion about their hip and associated problems
時間枠：Year 5

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 5
Predicting discharge destination after total joint arthroplasty.
時間枠：Day 0

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Day 0
Predicting discharge destination after total joint arthroplasty.
時間枠：Month 6

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Month 6
Physical function in myositis patients
時間枠：Day 0

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Day 0
Physical function in myositis patients
時間枠：Month 6

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Month 6
Physical function in myositis patients
時間枠：Year 1

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 1
Physical function in myositis patients
時間枠：Year 2

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 2
Physical function in myositis patients
時間枠：Year 5

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 5
Quality of life in Parkinson's Disease
時間枠：Day 0

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Day 0
Quality of life in Parkinson's Disease
時間枠：Month 6

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Month 6
Quality of life in Parkinson's Disease
時間枠：Year 1

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 1
Quality of life in Parkinson's Disease
時間枠：Year 2

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 2
Quality of life in Parkinson's Disease
時間枠：Year 5

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 5
Actimetry.
時間枠：during 5 consecutive days after day 0

Actimetry data (energy expenditure, number of steps, sedentary time, total physical activity, etc.) will be obtained with the WGT3X-BT Actigraph inertial sensor unit.
during 5 consecutive days after day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
時間枠：Day 0

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
時間枠：Month 6

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
時間枠：Year 1

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
時間枠：Year 2

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
時間枠：Year 5

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
時間枠：Day 0

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
時間枠：Month 6

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
時間枠：Year 1

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
時間枠：Year 2

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
時間枠：Year 5

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
時間枠：Day 0

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
時間枠：Month 6

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
時間枠：Year 1

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
時間枠：Year 2

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
時間枠：Year 5

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
時間枠：Day 0

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
時間枠：Month 6

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
時間枠：Year 1

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
時間枠：Year 2

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
時間枠：Year 5

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
時間枠：Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
時間枠：Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
時間枠：Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

University Hospital, Clermont-Ferrand

協力者

I-SITE Cap 20-25 project

捜査官

  • 主任研究者：Frédéric Costes、University Hospital, Clermont-Ferrand

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始 (実際)

2020年8月27日

一次修了 (推定)

2035年8月26日

研究の完了 (推定)

2035年8月26日

試験登録日

最初に提出

2020年4月27日

QC基準を満たした最初の提出物

2020年5月4日

最初の投稿 (実際)

2020年5月5日

学習記録の更新

投稿された最後の更新 (実際)

2026年11月4日

QC基準を満たした最後の更新が送信されました

2026年11月2日

最終確認日

2026年10月1日

詳しくは

本研究に関する用語

キーワード

追加の関連 MeSH 用語

その他の研究ID番号

  • RBHP 2019 COSTES
  • 2019-A01017-50 (その他の識別子：2019-A01017-50)

医薬品およびデバイス情報、研究文書

米国FDA規制医薬品の研究

いいえ

米国FDA規制機器製品の研究

いいえ

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