Questa pagina è stata tradotta automaticamente e l'accuratezza della traduzione non è garantita. Si prega di fare riferimento al Versione inglese per un testo di partenza.

Valutazione della mobilità compromessa nella costituzione della malattia cronica di una coorte (EVALMOB)

2 novembre 2026 aggiornato da: University Hospital, Clermont-Ferrand

Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge both for the treatment of causal pathologies, as well as for evaluating the impact of therapeutic interventions, the benefit of which will be an improvement in physical capacities and ultimately mobility. In view of the hypothesis of an increase in the prevalence of mobility disorders in this population, this approach is part of a logic of screening and improving the effectiveness of the care of these patients with a multidisciplinary evaluation of individual risks. The EVALMOB protocol was designed in order to try to determine a standard profile of "dysmobility" in patients with chronic illness

Panoramica dello studio

Stato

Reclutamento

Condizioni

Intervento / Trattamento

Descrizione dettagliata

We propose to constitute a prospective cohort of subjects carrying chronic disease. The objective is to explore all the different components of mobility (balance, muscle force, body composition, walking ability, metabolism, etc.), to assess their impact on the functional capacity of individuals and to identify their potential interactions. Processing this data could ultimately allow the development of a model to determine a composite standard profile of "dysmobility" in patients with chronic disease.

In the present protocol, parameters will be measured on five occasions (at inclusion, at 6 months from the inclusion day, at 1,2 and 5 year(s) from the inclusion day). All tests will be performed on the same day. New assessments will be done on the same principle as the initial evaluation.

Statistical analyses will be carried out using Stata software (version 13, StataCorp, College Station, USA). Data will be described by frequencies and percentages for categorical variables and by means and standard deviation (or median and interquartile range if data are not normally distributed) for continuous variables. The normality of continuous data will be assessed graphically and using the Shapiro-Wilk test. The main analysis will consist in determining patient profiles regarding their mobility. Clustering-type approaches (supervised or not) will be proposed: k-means, vector machine support, machine learning, factor analysis. For example, factor analyses on mixed data will allow the main components of mobility to be characterized. They can be followed by an ascending hierarchical classification in order to determine homogeneous groups of patients.

These groups will be described and compared on the main criteria evaluated using standard statistical tests: chi2 test (or Fisher's exact test if applicable) for the categorical criteria and using an analysis of variance (or Kruskal-Wallis if data are not normally distributed) for continuous criteria. The main analysis will be broken down more specifically for each of the pathologies considered. In addition, the sensitivity to change will be assessed in each pathology and for each assessment criterion. The search for factors related to the evolution of the different criteria will be carried out using usual tests and mixed multivariate models (logistics for categorical / linear criteria for continuous criteria) considering the subject as a random effect, and adjusting on the time criteria (inclusion / follow-up) and the criteria highlighted in the univariate analyses and in light of the elements reported in the literature. A sensitivity analysis will be proposed in order to study the statistical nature of the missing data and to propose, if necessary, the most suitable method of imputing the data: multiple imputation, maximum bias or LOCF in the case of longitudinal data.

Tipo di studio

Interventistico

Iscrizione (Stimato)

5000

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Contatto studio

Luoghi di studio

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

Da 18 anni a 90 anni (Adulto, Adulto più anziano)

Accetta volontari sani

No

Sessi ammissibili allo studio

Tutto

Descrizione

Inclusion Criteria:

  • Man or woman aged 18 to 90.
  • Patients with chronic pathology contributing to impaired mobility.
  • Volunteers who have given their written consent.
  • Affiliated to French health care system (for France)

Exclusion Criteria:

  • Patients suffering from progressive psychiatric pathologies (active psychosis, hallucinations, etc.) or the presence of another serious unstabilized pathology (decompensated heart failure, progressive terminal cancer, etc.).
  • People with poorly controlled or unstable cardiovascular disease.
  • Major osteoarticular or neurological problems completely preventing the proper performance of the various tests.
  • Non-autonomous patient
  • Persons under guardianship, curatorship, deprived of liberty or safeguarding justice.
  • People excluded from another study.
  • Pregnant or lactating women.

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Diagnostico
  • Assegnazione: N / A
  • Modello interventistico: Assegnazione di gruppo singolo
  • Mascheramento: Nessuno (etichetta aperta)

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Sperimentale: Cohort 1

Participants will be involved in a long-term evaluation program combining, body composition measures, physical tests as well as self-administered questionnaires. Participants will be followed for 5 years with evaluations taking place at inclusion, 6 months, at 1, 2 and 5 years
Altro: Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.

Firstly, volunteers will be invited to complete online questionnaires on a secure platform. The mobility assessment will be carried out initially (t1) and up to a maximum of 4 times (t1 to t4) as part of a day hospitalization. Questionnaires will be diverse (SF36, KOOS, HOOS, BROCKER, MNA, TAMPA, etc.) in order to assess several aspects that compose mobility.

Physical evaluations will include various validated tests (isokinetic strength measure, TUG, 6MWT, Berg Balance Scale, etc.)

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
dismobility score calculated from the results reported in secondary outcomes
Lasso di tempo: Day 0

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Day 0
dismobility score calculated from the results reported in secondary outcomes
Lasso di tempo: Month 6

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Month 6
dismobility score calculated from the results reported in secondary outcomes
Lasso di tempo: Year 1

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 1
dismobility score calculated from the results reported in secondary outcomes
Lasso di tempo: Year 2

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 2
dismobility score calculated from the results reported in secondary outcomes
Lasso di tempo: Year 5

The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Year 5

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles
Lasso di tempo: Day 0

Demographics information will be obtained using a single questionnaire including questions on age, gender, qualification, personal work status, ethnicity, life and occupational events.
Day 0
Weight (Kg).
Lasso di tempo: Day 0

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Day 0
Weight (Kg).
Lasso di tempo: Month 6

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Month 6
Weight (Kg).
Lasso di tempo: Year 1

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 1
Weight (Kg).
Lasso di tempo: Year 2

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 2
Weight (Kg).
Lasso di tempo: Year 5

Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.
Year 5
Height (cm).
Lasso di tempo: Day 0

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Day 0
Height (cm).
Lasso di tempo: Month 6

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Month 6
Height (cm).
Lasso di tempo: Year 1

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 1
Height (cm).
Lasso di tempo: Year 2

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 2
Height (cm).
Lasso di tempo: Year 5

Height will be measured with a wall mounted tape measure and according to the ISAK recommendations
Year 5
Body fat percentage (%).
Lasso di tempo: Day 0

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Day 0
Body fat percentage (%).
Lasso di tempo: Month 6

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Month 6
Body fat percentage (%).
Lasso di tempo: Year 1

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 1
Body fat percentage (%).
Lasso di tempo: Year 2

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 2
Body fat percentage (%).
Lasso di tempo: Year 5

Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).
Year 5
Waist circumference (cm).
Lasso di tempo: Day 0

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Waist circumference (cm).
Lasso di tempo: Month 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 5
Waist circumference (cm).
Lasso di tempo: Year 1

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Waist circumference (cm).
Lasso di tempo: Year 2

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Waist circumference (cm).
Lasso di tempo: Year 5

Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Hip circumference (cm).
Lasso di tempo: Day 0

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Hip circumference (cm).
Lasso di tempo: Month 6

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Hip circumference (cm).
Lasso di tempo: Year 1

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Hip circumference (cm).
Lasso di tempo: Year 2

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Hip circumference (cm).
Lasso di tempo: Year 5

Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Brachial circumference (cm).
Lasso di tempo: Day 0

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Day 0
Brachial circumference (cm).
Lasso di tempo: Month 6

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Month 6
Brachial circumference (cm).
Lasso di tempo: Year 1

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 1
Brachial circumference (cm).
Lasso di tempo: Year 2

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 2
Brachial circumference (cm).
Lasso di tempo: Year 5

Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.
Year 5
Calf circumference (cm).
Lasso di tempo: Day 0

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Day 0
Calf circumference (cm).
Lasso di tempo: Month 6

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Month 6
Calf circumference (cm).
Lasso di tempo: Year 1

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 1
Calf circumference (cm).
Lasso di tempo: Year 2

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 2
Calf circumference (cm).
Lasso di tempo: Year 5

Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations
Year 5
Body Mass Index (Kg/m²).
Lasso di tempo: Day 0

BMI will be calculated (weight in kilograms divided by height in meters squared).
Day 0
Body Mass Index (Kg/m²).
Lasso di tempo: Month 6

BMI will be calculated (weight in kilograms divided by height in meters squared).
Month 6
Body Mass Index (Kg/m²).
Lasso di tempo: Year 1

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 1
Body Mass Index (Kg/m²).
Lasso di tempo: Year 2

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 2
Body Mass Index (Kg/m²).
Lasso di tempo: Year 5

BMI will be calculated (weight in kilograms divided by height in meters squared).
Year 5
Body composition
Lasso di tempo: Day 0

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Day 0
Body composition
Lasso di tempo: Month 6

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Month 6
Body composition
Lasso di tempo: Year 1

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 1
Body composition
Lasso di tempo: Year 2

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 2
Body composition
Lasso di tempo: Year 5

Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.
Year 5
T-score (DS).
Lasso di tempo: DAy 0

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
DAy 0
T-score (DS).
Lasso di tempo: Month 6

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
T-score (DS).
Lasso di tempo: Year 1

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
T-score (DS).
Lasso di tempo: Year 2

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
T-score (DS).
Lasso di tempo: Year 5

- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Z-score (DS).
Lasso di tempo: Day 0

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Z-score (DS).
Lasso di tempo: Month 6

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Z-score (DS).
Lasso di tempo: Year 1

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Z-score (DS).
Lasso di tempo: Year 2

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Z-score (DS).
Lasso di tempo: Year 5

Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Fat mass
Lasso di tempo: Day 0

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mass
Lasso di tempo: Month 6

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mass
Lasso di tempo: Year 1

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mass
Lasso di tempo: Year 2

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mass
Lasso di tempo: Year 5

Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass (%).
Lasso di tempo: Day 0

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass (%).
Lasso di tempo: Month 6

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass (%).
Lasso di tempo: Year 1

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass (%).
Lasso di tempo: Year 2

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass (%).
Lasso di tempo: Year 5

: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat mas index (Kg/m²).
Lasso di tempo: Day 0

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat mas index (Kg/m²).
Lasso di tempo: Month 6

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat mas index (Kg/m²).
Lasso di tempo: Year 1

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat mas index (Kg/m²).
Lasso di tempo: Year 2

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat mas index (Kg/m²).
Lasso di tempo: Year 5

Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Ratio of android to gynoid fat mass.
Lasso di tempo: Day 0

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Day 0
Ratio of android to gynoid fat mass.
Lasso di tempo: Month 6

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Month 6
Ratio of android to gynoid fat mass.
Lasso di tempo: Year 1

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 1
Ratio of android to gynoid fat mass.
Lasso di tempo: Year 2

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 2
Ratio of android to gynoid fat mass.
Lasso di tempo: Year 5

Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer
Year 5
Visceral adipose tissue (Kg).
Lasso di tempo: Day 0

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Visceral adipose tissue (Kg).
Lasso di tempo: Month 6

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Visceral adipose tissue (Kg).
Lasso di tempo: Year 1

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Visceral adipose tissue (Kg).
Lasso di tempo: Year 2

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Visceral adipose tissue (Kg).
Lasso di tempo: Year 5

Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Fat-free mass index (kg/m²).
Lasso di tempo: Day 0

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Fat-free mass index (kg/m²).
Lasso di tempo: Month 6

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Fat-free mass index (kg/m²).
Lasso di tempo: Year 1

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Fat-free mass index (kg/m²).
Lasso di tempo: Year 2

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Fat-free mass index (kg/m²).
Lasso di tempo: Year 5

: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Appendicular fat-free mass index (Kg/m²).
Lasso di tempo: Day 0

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Appendicular fat-free mass index (Kg/m²).
Lasso di tempo: Month 6

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Appendicular fat-free mass index (Kg/m²).
Lasso di tempo: Year 1

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Appendicular fat-free mass index (Kg/m²).
Lasso di tempo: Year 2

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Appendicular fat-free mass index (Kg/m²).
Lasso di tempo: Year 5

Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Bone mass (Kg)
Lasso di tempo: Day 0

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Day 0
Bone mass (Kg)
Lasso di tempo: Month 6

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Month 6
Bone mass (Kg)
Lasso di tempo: Year 1

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 1
Bone mass (Kg)
Lasso di tempo: Year 2

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 2
Bone mass (Kg)
Lasso di tempo: Year 5

- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.
Year 5
Daily caloric intake (Kcal/24h).
Lasso di tempo: Day 0

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily caloric intake (Kcal/24h).
Lasso di tempo: Month 6

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily caloric intake (Kcal/24h).
Lasso di tempo: Year 1

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily caloric intake (Kcal/24h).
Lasso di tempo: Year 2

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily caloric intake (Kcal/24h).
Lasso di tempo: Year 5

Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily protein intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Day 0

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily protein intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Month 6

Daily protein intake (in g and as a percentage of total caloric intake).
Month 6
Daily protein intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 1

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily protein intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 2

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily protein intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 5

Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Day 0

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Month 6

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 1

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 2

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily carbohydrate intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 5

Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Daily fat intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Day 0

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Day 0
Daily fat intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Month 6

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Month 6
Daily fat intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 1

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 1
Daily fat intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 2

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 2
Daily fat intake (in g and as a percentage of total caloric intake).
Lasso di tempo: Year 5

Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).
Year 5
Nutritional status assessment
Lasso di tempo: Day 0

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Day 0
Nutritional status assessment
Lasso di tempo: Month 6

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Month 6
Nutritional status assessment
Lasso di tempo: Year 1

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 1
Nutritional status assessment
Lasso di tempo: Year 2

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 2
Nutritional status assessment
Lasso di tempo: Year 5

Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.
Year 5
Risk of undernutrition.
Lasso di tempo: Day 0

Risk of undernutrition will be assessed with the Brocker Questionnaire
Day 0
Risk of undernutrition.
Lasso di tempo: Month 6

Risk of undernutrition will be assessed with the Brocker Questionnaire
Month 6
Risk of undernutrition.
Lasso di tempo: Year 1

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 1
Risk of undernutrition.
Lasso di tempo: Year 2

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 2
Risk of undernutrition.
Lasso di tempo: Year 5

Risk of undernutrition will be assessed with the Brocker Questionnaire
Year 5
Basic biology.
Lasso di tempo: Day 0

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Day 0
Basic biology.
Lasso di tempo: Month 6

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Month 6
Basic biology.
Lasso di tempo: Year 1

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 1
Basic biology.
Lasso di tempo: Year 2

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 2
Basic biology.
Lasso di tempo: Year 5

: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)
Year 5
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Lasso di tempo: Day 0

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Lasso di tempo: Month 6

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Lasso di tempo: Year 1

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Lasso di tempo: Year 2

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).
Lasso di tempo: Year 5

: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Lasso di tempo: Day 0

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Lasso di tempo: Month 6

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Lasso di tempo: Year 1

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Lasso di tempo: Year 2

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).
Lasso di tempo: Year 5

- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Lasso di tempo: Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Lasso di tempo: Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Lasso di tempo: Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Lasso di tempo: Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).
Lasso di tempo: Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Day 0

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Month 6

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Year 1

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Year 2

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Year 5

Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Lasso di tempo: Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Lasso di tempo: Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Lasso di tempo: Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Lasso di tempo: Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).
Lasso di tempo: Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Lasso di tempo: Day 0

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Lasso di tempo: Month 6

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Lasso di tempo: Year 1

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Lasso di tempo: Year 2

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).
Lasso di tempo: Year 5

- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.
Year 5
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Day 0

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Day 0
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Month 6

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Month 6
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Year 1

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 1
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Year 2

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 2
Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).
Lasso di tempo: Year 5

Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the quadriceps muscles at 180°/s.
Lasso di tempo: Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Day 0
Endurance coefficient of the quadriceps muscles at 180°/s.
Lasso di tempo: Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Month 6
Endurance coefficient of the quadriceps muscles at 180°/s.
Lasso di tempo: Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 1
Endurance coefficient of the quadriceps muscles at 180°/s.
Lasso di tempo: Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 2
Endurance coefficient of the quadriceps muscles at 180°/s.
Lasso di tempo: Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.
Year 5
Endurance coefficient of the hamstring muscles at 180°/s.
Lasso di tempo: Day 0

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Day 0
Endurance coefficient of the hamstring muscles at 180°/s.
Lasso di tempo: Month 6

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Month 6
Endurance coefficient of the hamstring muscles at 180°/s.
Lasso di tempo: Year 1

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 1
Endurance coefficient of the hamstring muscles at 180°/s.
Lasso di tempo: Year 2

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 2
Endurance coefficient of the hamstring muscles at 180°/s.
Lasso di tempo: Year 5

Endurance coefficient will be estimated as a Σ Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..
Year 5
Functional ratio
Lasso di tempo: Day 0

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Day 0
Functional ratio
Lasso di tempo: Month 6

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Month 6
Functional ratio
Lasso di tempo: Year 1

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 1
Functional ratio
Lasso di tempo: Year 2

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 2
Functional ratio
Lasso di tempo: Year 5

Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.
Year 5
Mixed ratio
Lasso di tempo: Day 0

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Day 0
Mixed ratio
Lasso di tempo: Month 6

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Month 6
Mixed ratio
Lasso di tempo: Year 1

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 1
Mixed ratio
Lasso di tempo: Year 2

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 2
Mixed ratio
Lasso di tempo: Year 5

- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.
Year 5
Maximum voluntary hand grip strength (Kg).
Lasso di tempo: Day 0

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Day 0
Maximum voluntary hand grip strength (Kg).
Lasso di tempo: Month 6

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Month 6
Maximum voluntary hand grip strength (Kg).
Lasso di tempo: Year 1

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 1
Maximum voluntary hand grip strength (Kg).
Lasso di tempo: Year 2

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 2
Maximum voluntary hand grip strength (Kg).
Lasso di tempo: Year 5

Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.
Year 5
Maximum voluntary pinch strength (Kg).
Lasso di tempo: Day 0

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Day 0
Maximum voluntary pinch strength (Kg).
Lasso di tempo: Month 6

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Month 6
Maximum voluntary pinch strength (Kg).
Lasso di tempo: Year 1

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 1
Maximum voluntary pinch strength (Kg).
Lasso di tempo: Year 2

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 2
Maximum voluntary pinch strength (Kg).
Lasso di tempo: Year 5

Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.
Year 5
Hip passive joint range
Lasso di tempo: Day 0

Hip joint range will be measured with a medical goniometer.
Day 0
Hip passive joint range
Lasso di tempo: Month 6

Hip joint range will be measured with a medical goniometer.
Month 6
Hip passive joint range
Lasso di tempo: Year 1

Hip joint range will be measured with a medical goniometer.
Year 1
Hip passive joint range
Lasso di tempo: Year 2

Hip joint range will be measured with a medical goniometer.
Year 2
Hip passive joint range
Lasso di tempo: Year 5

Hip joint range will be measured with a medical goniometer.
Year 5
Knee passive joint range.
Lasso di tempo: Day 0

Knee joint range will be measured with a medical goniometer.
Day 0
Knee passive joint range.
Lasso di tempo: Month 6

Knee joint range will be measured with a medical goniometer.
Month 6
Knee passive joint range.
Lasso di tempo: Year 1

Knee joint range will be measured with a medical goniometer.
Year 1
Knee passive joint range.
Lasso di tempo: Year 2

Knee joint range will be measured with a medical goniometer.
Year 2
Knee passive joint range.
Lasso di tempo: Year 5

Knee joint range will be measured with a medical goniometer.
Year 5
Ankle passive joint range
Lasso di tempo: Day 0

Ankle joint range will be measured with a medical goniometer.
Day 0
Ankle passive joint range
Lasso di tempo: Month 6

Ankle joint range will be measured with a medical goniometer.
Month 6
Ankle passive joint range
Lasso di tempo: Year 1

Ankle joint range will be measured with a medical goniometer.
Year 1
Ankle passive joint range
Lasso di tempo: Year 2

Ankle joint range will be measured with a medical goniometer.
Year 2
Ankle passive joint range
Lasso di tempo: Year 5

Ankle joint range will be measured with a medical goniometer.
Year 5
Lower and upper limb muscle power assessment (MRC)
Lasso di tempo: Day 0

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Day 0
Lower and upper limb muscle power assessment (MRC)
Lasso di tempo: Month 6

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Month 6
Lower and upper limb muscle power assessment (MRC)
Lasso di tempo: Year 1

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 1
Lower and upper limb muscle power assessment (MRC)
Lasso di tempo: Year 2

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 2
Lower and upper limb muscle power assessment (MRC)
Lasso di tempo: Year 5

Lower and upper limb muscle power assessment will be performed by an experienced physician.
Year 5
Statokinesigram surface area (mm²)
Lasso di tempo: Day 0

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Day 0
Statokinesigram surface area (mm²)
Lasso di tempo: Month 6

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Month 6
Statokinesigram surface area (mm²)
Lasso di tempo: Year 1

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 1
Statokinesigram surface area (mm²)
Lasso di tempo: Year 2

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 2
Statokinesigram surface area (mm²)
Lasso di tempo: Year 5

Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.
Year 5
Stabilogram length (mm).
Lasso di tempo: Day 0

Stabilogram length will be measured with the STATIPRO® static posturography platform
Day 0
Stabilogram length (mm).
Lasso di tempo: Month 6

Stabilogram length will be measured with the STATIPRO® static posturography platform
Month 6
Stabilogram length (mm).
Lasso di tempo: Year 1

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 1
Stabilogram length (mm).
Lasso di tempo: Year 2

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 2
Stabilogram length (mm).
Lasso di tempo: Year 5

Stabilogram length will be measured with the STATIPRO® static posturography platform
Year 5
Maximal deflection (forward, backward left and right).
Lasso di tempo: Day 0

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Day 0
Maximal deflection (forward, backward left and right).
Lasso di tempo: Month 6

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Month 6
Maximal deflection (forward, backward left and right).
Lasso di tempo: Year 1

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 1
Maximal deflection (forward, backward left and right).
Lasso di tempo: Year 2

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 2
Maximal deflection (forward, backward left and right).
Lasso di tempo: Year 5

Maximal deflection will be measured with the STATIPRO® static posturography platform.
Year 5
Velocity variations (mm/s).
Lasso di tempo: Day 0

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Day 0
Velocity variations (mm/s).
Lasso di tempo: Month 6

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Month 6
Velocity variations (mm/s).
Lasso di tempo: Year 1

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 1
Velocity variations (mm/s).
Lasso di tempo: Year 2

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 2
Velocity variations (mm/s).
Lasso di tempo: Year 5

: Velocity variations will be measured with the STATIPRO® static posturography platform.
Year 5
: Romberg ratio according to sway area
Lasso di tempo: Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
: Romberg ratio according to sway area
Lasso di tempo: Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
: Romberg ratio according to sway area
Lasso di tempo: Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
: Romberg ratio according to sway area
Lasso di tempo: Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
: Romberg ratio according to sway area
Lasso di tempo: Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
Romberg ratio according to center of pressure path length
Lasso di tempo: Day 0

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Day 0
Romberg ratio according to center of pressure path length
Lasso di tempo: Month 6

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Month 6
Romberg ratio according to center of pressure path length
Lasso di tempo: Year 1

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 1
Romberg ratio according to center of pressure path length
Lasso di tempo: Year 2

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 2
Romberg ratio according to center of pressure path length
Lasso di tempo: Year 5

Romberg ratio will be measured with the STATIPRO® static posturography platform.
Year 5
: Plantar pressure ratio sway area.
Lasso di tempo: Day 0

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Day 0
: Plantar pressure ratio sway area.
Lasso di tempo: Month 6

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Month 6
: Plantar pressure ratio sway area.
Lasso di tempo: Year 1

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 1
: Plantar pressure ratio sway area.
Lasso di tempo: Year 2

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 2
: Plantar pressure ratio sway area.
Lasso di tempo: Year 5

Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.
Year 5
Plantar pressure ratio length.
Lasso di tempo: Day 0

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Day 0
Plantar pressure ratio length.
Lasso di tempo: Month 6

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Month 6
Plantar pressure ratio length.
Lasso di tempo: Year 1

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 1
Plantar pressure ratio length.
Lasso di tempo: Year 2

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 2
Plantar pressure ratio length.
Lasso di tempo: Year 5

Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.
Year 5
Walking velocity (cm/s).
Lasso di tempo: Day 0

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Day 0
Walking velocity (cm/s).
Lasso di tempo: Month 6

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Month 6
Walking velocity (cm/s).
Lasso di tempo: Year 1

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 1
Walking velocity (cm/s).
Lasso di tempo: Year 2

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 2
Walking velocity (cm/s).
Lasso di tempo: Year 5

Walking velocity will be measured with the GAITRite® Electronic Walkway.
Year 5
Cadence (steps/min).
Lasso di tempo: Day 0

: Cadence will be measured with the GAITRite® Electronic Walkway.
Day 0
Cadence (steps/min).
Lasso di tempo: Month 6

: Cadence will be measured with the GAITRite® Electronic Walkway.
Month 6
Cadence (steps/min).
Lasso di tempo: Year 1

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 1
Cadence (steps/min).
Lasso di tempo: Year 2

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 2
Cadence (steps/min).
Lasso di tempo: Year 5

: Cadence will be measured with the GAITRite® Electronic Walkway.
Year 5
Step length (left and right foot) (cm)
Lasso di tempo: DAy 0

Step length will be measured with the GAITRite® Electronic Walkway.
DAy 0
Step length (left and right foot) (cm)
Lasso di tempo: Month 6

Step length will be measured with the GAITRite® Electronic Walkway.
Month 6
Step length (left and right foot) (cm)
Lasso di tempo: Year 1

Step length will be measured with the GAITRite® Electronic Walkway.
Year 1
Step length (left and right foot) (cm)
Lasso di tempo: Year 2

Step length will be measured with the GAITRite® Electronic Walkway.
Year 2
Step length (left and right foot) (cm)
Lasso di tempo: Year 5

Step length will be measured with the GAITRite® Electronic Walkway.
Year 5
Stride length (cm).
Lasso di tempo: Day 0

Stride length will be measured with the GAITRite® Electronic Walkway.
Day 0
Stride length (cm).
Lasso di tempo: month 6

Stride length will be measured with the GAITRite® Electronic Walkway.
month 6
Stride length (cm).
Lasso di tempo: year 1

Stride length will be measured with the GAITRite® Electronic Walkway.
year 1
Stride length (cm).
Lasso di tempo: year 2

Stride length will be measured with the GAITRite® Electronic Walkway.
year 2
Stride length (cm).
Lasso di tempo: year 5

Stride length will be measured with the GAITRite® Electronic Walkway.
year 5
Single support time left and right foot (s).
Lasso di tempo: Day 0

Single support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Single support time left and right foot (s).
Lasso di tempo: Month 6

Single support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Single support time left and right foot (s).
Lasso di tempo: Year 1

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 1
Single support time left and right foot (s).
Lasso di tempo: Year 2

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Single support time left and right foot (s).
Lasso di tempo: Year 5

Single support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Double support time (s).
Lasso di tempo: Day 0

: Double support time will be measured with the GAITRite® Electronic Walkway.
Day 0
Double support time (s).
Lasso di tempo: Month 6

: Double support time will be measured with the GAITRite® Electronic Walkway.
Month 6
Double support time (s).
Lasso di tempo: YEar 1

: Double support time will be measured with the GAITRite® Electronic Walkway.
YEar 1
Double support time (s).
Lasso di tempo: Year 2

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 2
Double support time (s).
Lasso di tempo: Year 5

: Double support time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing time (s).
Lasso di tempo: Day 0

: Swing time will be measured with the GAITRite® Electronic Walkway.
Day 0
Swing time (s).
Lasso di tempo: Month 6

: Swing time will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing time (s).
Lasso di tempo: Year 1

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing time (s).
Lasso di tempo: Year 2

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing time (s).
Lasso di tempo: Year 5

: Swing time will be measured with the GAITRite® Electronic Walkway.
Year 5
Swing phase (as a % of walking cycle).
Lasso di tempo: DAy 0

: Swing phase will be measured with the GAITRite® Electronic Walkway.
DAy 0
Swing phase (as a % of walking cycle).
Lasso di tempo: Month 6

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Swing phase (as a % of walking cycle).
Lasso di tempo: Year 1

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Swing phase (as a % of walking cycle).
Lasso di tempo: Year 2

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Swing phase (as a % of walking cycle).
Lasso di tempo: Year 5

: Swing phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Stance phase (as a % of walking cycle).
Lasso di tempo: Day 0

Stance phase will be measured with the GAITRite® Electronic Walkway.
Day 0
Stance phase (as a % of walking cycle).
Lasso di tempo: Month 6

Stance phase will be measured with the GAITRite® Electronic Walkway.
Month 6
Stance phase (as a % of walking cycle).
Lasso di tempo: Year 1

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 1
Stance phase (as a % of walking cycle).
Lasso di tempo: Year 2

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 2
Stance phase (as a % of walking cycle).
Lasso di tempo: Year 5

Stance phase will be measured with the GAITRite® Electronic Walkway.
Year 5
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Lasso di tempo: Day 0

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Lasso di tempo: Month 6

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Lasso di tempo: Year 1

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Lasso di tempo: Year 2

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Vo2max (maximal oxygen consumption) (mL/Kg/min).
Lasso di tempo: Year 5

: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum heart rate (bpm).
Lasso di tempo: Day 0

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum heart rate (bpm).
Lasso di tempo: Month 6

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum heart rate (bpm).
Lasso di tempo: Year 1

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum heart rate (bpm).
Lasso di tempo: Year 2

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum heart rate (bpm).
Lasso di tempo: Year 5

Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Maximum power (Watts).
Lasso di tempo: Day 0

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Maximum power (Watts).
Lasso di tempo: Month 6

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Maximum power (Watts).
Lasso di tempo: Year 1

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Maximum power (Watts).
Lasso di tempo: Year 2

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Maximum power (Watts).
Lasso di tempo: Year 5

Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold power (Watts).
Lasso di tempo: Day 0

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Threshold power (Watts).
Lasso di tempo: Month 6

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold power (Watts).
Lasso di tempo: Year 1

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold power (Watts).
Lasso di tempo: Year 2

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold power (Watts).
Lasso di tempo: Year 5

Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Threshold heart rate (bpm).
Lasso di tempo: DAy 0

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
DAy 0
Threshold heart rate (bpm).
Lasso di tempo: Month 6

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Threshold heart rate (bpm).
Lasso di tempo: Year 1

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Threshold heart rate (bpm).
Lasso di tempo: Year 2

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Threshold heart rate (bpm).
Lasso di tempo: Year 5

Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Forced vital Capacity (L).
Lasso di tempo: Day 0

: Forced vital Capacity will be measured with a spirometry test.
Day 0
Forced vital Capacity (L).
Lasso di tempo: Month 6

: Forced vital Capacity will be measured with a spirometry test.
Month 6
Forced vital Capacity (L).
Lasso di tempo: Year 1

: Forced vital Capacity will be measured with a spirometry test.
Year 1
Forced vital Capacity (L).
Lasso di tempo: Year 2

: Forced vital Capacity will be measured with a spirometry test.
Year 2
Forced vital Capacity (L).
Lasso di tempo: Year 5

: Forced vital Capacity will be measured with a spirometry test.
Year 5
Forced Expiratory volume (L)
Lasso di tempo: Day 0

Forced Expiratory volume will be measured with a spirometry test.
Day 0
Forced Expiratory volume (L)
Lasso di tempo: Month 6

Forced Expiratory volume will be measured with a spirometry test.
Month 6
Forced Expiratory volume (L)
Lasso di tempo: Year 1

Forced Expiratory volume will be measured with a spirometry test.
Year 1
Forced Expiratory volume (L)
Lasso di tempo: Year 2

Forced Expiratory volume will be measured with a spirometry test.
Year 2
Forced Expiratory volume (L)
Lasso di tempo: Year 5

Forced Expiratory volume will be measured with a spirometry test.
Year 5
Tiffeneau ratio (%).
Lasso di tempo: Day 0

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Day 0
Tiffeneau ratio (%).
Lasso di tempo: Month 6

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Month 6
Tiffeneau ratio (%).
Lasso di tempo: Year 1

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 1
Tiffeneau ratio (%).
Lasso di tempo: Year 2

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 2
Tiffeneau ratio (%).
Lasso di tempo: Year 5

Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.
Year 5
Ventilatory reserve (%).
Lasso di tempo: Day 0

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Day 0
Ventilatory reserve (%).
Lasso di tempo: Month 6

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Month 6
Ventilatory reserve (%).
Lasso di tempo: Year 1

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 1
Ventilatory reserve (%).
Lasso di tempo: Year 2

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 2
Ventilatory reserve (%).
Lasso di tempo: Year 5

Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.
Year 5
Physical activity
Lasso di tempo: Day 0

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Day 0
Physical activity
Lasso di tempo: Month 6

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Month 6
Physical activity
Lasso di tempo: Year 1

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 1
Physical activity
Lasso di tempo: Year 2

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 2
Physical activity
Lasso di tempo: Year 5

Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)
Year 5
Functional capacity timed-up and go
Lasso di tempo: Day 0

Functional capacity will be evaluated using the Timed-Up and Go test.
Day 0
Functional capacity timed-up and go
Lasso di tempo: Month 6

Functional capacity will be evaluated using the Timed-Up and Go test.
Month 6
Functional capacity timed-up and go
Lasso di tempo: Year 1

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 1
Functional capacity timed-up and go
Lasso di tempo: Year 2

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 2
Functional capacity timed-up and go
Lasso di tempo: Year 5

Functional capacity will be evaluated using the Timed-Up and Go test.
Year 5
Functional capacity TDM6
Lasso di tempo: Day 0

Functional capacity will be evaluated using the 6-minute walk test.
Day 0
Functional capacity TDM6
Lasso di tempo: Month 6

Functional capacity will be evaluated using the 6-minute walk test.
Month 6
Functional capacity TDM6
Lasso di tempo: Year 1

Functional capacity will be evaluated using the 6-minute walk test.
Year 1
Functional capacity TDM6
Lasso di tempo: Year 2

Functional capacity will be evaluated using the 6-minute walk test.
Year 2
Functional capacity TDM6
Lasso di tempo: Year 5

Functional capacity will be evaluated using the 6-minute walk test.
Year 5
Functional capacity Five Times Sit to Stand test.
Lasso di tempo: Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Day 0
Functional capacity Five Times Sit to Stand test.
Lasso di tempo: Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Month 6
Functional capacity Five Times Sit to Stand test.
Lasso di tempo: Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 1
Functional capacity Five Times Sit to Stand test.
Lasso di tempo: Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 2
Functional capacity Five Times Sit to Stand test.
Lasso di tempo: Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.
Year 5
Functional capacity SPPB
Lasso di tempo: Day 0

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Day 0
Functional capacity SPPB
Lasso di tempo: Month 6

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Month 6
Functional capacity SPPB
Lasso di tempo: Year 1

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 1
Functional capacity SPPB
Lasso di tempo: Year 2

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 2
Functional capacity SPPB
Lasso di tempo: Year 5

Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.
Year 5
Functional capacity the mini-BESTest.
Lasso di tempo: Day 0

Functional capacity will be evaluated using the mini-BESTest.
Day 0
Functional capacity the mini-BESTest.
Lasso di tempo: Month 6

Functional capacity will be evaluated using the mini-BESTest.
Month 6
Functional capacity the mini-BESTest.
Lasso di tempo: Year 1

Functional capacity will be evaluated using the mini-BESTest.
Year 1
Functional capacity the mini-BESTest.
Lasso di tempo: Year 2

Functional capacity will be evaluated using the mini-BESTest.
Year 2
Functional capacity the mini-BESTest.
Lasso di tempo: Year 5

Functional capacity will be evaluated using the mini-BESTest.
Year 5
Functional capacity Berg Balance Scale.
Lasso di tempo: Day 0

Functional capacity will be evaluated using the Berg Balance Scale.
Day 0
Functional capacity Berg Balance Scale.
Lasso di tempo: Month 6

Functional capacity will be evaluated using the Berg Balance Scale.
Month 6
Functional capacity Berg Balance Scale.
Lasso di tempo: Year 1

Functional capacity will be evaluated using the Berg Balance Scale.
Year 1
Functional capacity Berg Balance Scale.
Lasso di tempo: Year 2

Functional capacity will be evaluated using the Berg Balance Scale.
Year 2
Functional capacity Berg Balance Scale.
Lasso di tempo: Year 5

Functional capacity will be evaluated using the Berg Balance Scale.
Year 5
Functional capacity 10-meter walk test
Lasso di tempo: Day 0

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Day 0
Functional capacity 10-meter walk test
Lasso di tempo: Month 6

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Month 6
Functional capacity 10-meter walk test
Lasso di tempo: Year 1

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 1
Functional capacity 10-meter walk test
Lasso di tempo: Year 2

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 2
Functional capacity 10-meter walk test
Lasso di tempo: Year 5

Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).
Year 5
Dyspnea
Lasso di tempo: Day 0

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Day 0
Dyspnea
Lasso di tempo: Month 6

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Dyspnea
Lasso di tempo: Year 1

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Dyspnea
Lasso di tempo: Year 2

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Dyspnea
Lasso di tempo: Year 5

Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Perceived exertion before, during and after effort
Lasso di tempo: DAy 0

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
DAy 0
Perceived exertion before, during and after effort
Lasso di tempo: Month 6

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Month 6
Perceived exertion before, during and after effort
Lasso di tempo: Year 1

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 1
Perceived exertion before, during and after effort
Lasso di tempo: Year 2

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 2
Perceived exertion before, during and after effort
Lasso di tempo: Year 5

Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.
Year 5
Musculoskeletal Pain
Lasso di tempo: Day 0

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Day 0
Musculoskeletal Pain
Lasso di tempo: Month 6

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Month 6
Musculoskeletal Pain
Lasso di tempo: Year 1

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 1
Musculoskeletal Pain
Lasso di tempo: Year 2

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 2
Musculoskeletal Pain
Lasso di tempo: Year 5

: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.
Year 5
Sarcopenia risk
Lasso di tempo: Day 0

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Day 0
Sarcopenia risk
Lasso di tempo: Month 6

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Month 6
Sarcopenia risk
Lasso di tempo: Year 1

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 1
Sarcopenia risk
Lasso di tempo: Year 2

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 2
Sarcopenia risk
Lasso di tempo: Year 5

Sarcopenia risk will be evaluated with the SARC-F Questionnaire.
Year 5
Social insecurity
Lasso di tempo: Day 0

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Day 0
Social insecurity
Lasso di tempo: Month 6

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Month 6
Social insecurity
Lasso di tempo: Year 1

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 1
Social insecurity
Lasso di tempo: Year 2

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 2
Social insecurity
Lasso di tempo: Year 5

Social insecurity will be evaluated with the EPICES Score Questionnaire.
Year 5
Kinesiophobia
Lasso di tempo: Day 0

Kinesiophobia will be evaluated with the TAMPA Scale.
Day 0
Kinesiophobia
Lasso di tempo: Month 6

Kinesiophobia will be evaluated with the TAMPA Scale.
Month 6
Kinesiophobia
Lasso di tempo: Year 1

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 1
Kinesiophobia
Lasso di tempo: Year 2

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 2
Kinesiophobia
Lasso di tempo: Year 5

Kinesiophobia will be evaluated with the TAMPA Scale.
Year 5
Quality of life
Lasso di tempo: Day 0

Quality of life will be evaluated with the 36-Item Short Form Survey.
Day 0
Quality of life
Lasso di tempo: Month 6

Quality of life will be evaluated with the 36-Item Short Form Survey.
Month 6
Quality of life
Lasso di tempo: Year 1

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 1
Quality of life
Lasso di tempo: Year 2

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 2
Quality of life
Lasso di tempo: Year 5

Quality of life will be evaluated with the 36-Item Short Form Survey.
Year 5
: Balance confidence in performing various activities
Lasso di tempo: Day 0

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Day 0
: Balance confidence in performing various activities
Lasso di tempo: Month 6

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Month 6
: Balance confidence in performing various activities
Lasso di tempo: Year 1

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 1
: Balance confidence in performing various activities
Lasso di tempo: Year 2

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 2
: Balance confidence in performing various activities
Lasso di tempo: Year 5

Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.
Year 5
Functioning in regards to activities of daily living.
Lasso di tempo: Day 0

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Day 0
Functioning in regards to activities of daily living.
Lasso di tempo: Month 6

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Month 6
Functioning in regards to activities of daily living.
Lasso di tempo: Year 1

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 1
Functioning in regards to activities of daily living.
Lasso di tempo: Year 2

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 2
Functioning in regards to activities of daily living.
Lasso di tempo: Year 5

Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.
Year 5
Exhaustion
Lasso di tempo: Day 0

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Day 0
Exhaustion
Lasso di tempo: Month 6

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Month 6
Exhaustion
Lasso di tempo: Year 1

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 1
Exhaustion
Lasso di tempo: Year 2

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 2
Exhaustion
Lasso di tempo: Year 5

Exhaustion will be evaluated with the FACIT-F Questionnaire.
Year 5
Patient's opinion about their knee and associated problems
Lasso di tempo: Day 0

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Day 0
Patient's opinion about their knee and associated problems
Lasso di tempo: Month 6

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Month 6
Patient's opinion about their knee and associated problems
Lasso di tempo: Year 1

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 1
Patient's opinion about their knee and associated problems
Lasso di tempo: Year 2

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 2
Patient's opinion about their knee and associated problems
Lasso di tempo: Year 5

: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).
Year 5
Patient's opinion about their hip and associated problems
Lasso di tempo: Day 0

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Day 0
Patient's opinion about their hip and associated problems
Lasso di tempo: Month 6

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Month 6
Patient's opinion about their hip and associated problems
Lasso di tempo: Year 1

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 1
Patient's opinion about their hip and associated problems
Lasso di tempo: Year 2

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 2
Patient's opinion about their hip and associated problems
Lasso di tempo: Year 5

Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).
Year 5
Predicting discharge destination after total joint arthroplasty.
Lasso di tempo: Day 0

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Day 0
Predicting discharge destination after total joint arthroplasty.
Lasso di tempo: Month 6

: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);
Month 6
Physical function in myositis patients
Lasso di tempo: Day 0

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Day 0
Physical function in myositis patients
Lasso di tempo: Month 6

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Month 6
Physical function in myositis patients
Lasso di tempo: Year 1

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 1
Physical function in myositis patients
Lasso di tempo: Year 2

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 2
Physical function in myositis patients
Lasso di tempo: Year 5

Physical function will be evaluated with the Stanford Health Assessment Questionnaire.
Year 5
Quality of life in Parkinson's Disease
Lasso di tempo: Day 0

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Day 0
Quality of life in Parkinson's Disease
Lasso di tempo: Month 6

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Month 6
Quality of life in Parkinson's Disease
Lasso di tempo: Year 1

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 1
Quality of life in Parkinson's Disease
Lasso di tempo: Year 2

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 2
Quality of life in Parkinson's Disease
Lasso di tempo: Year 5

Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).
Year 5
Actimetry.
Lasso di tempo: during 5 consecutive days after day 0

Actimetry data (energy expenditure, number of steps, sedentary time, total physical activity, etc.) will be obtained with the WGT3X-BT Actigraph inertial sensor unit.
during 5 consecutive days after day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Lasso di tempo: Day 0

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Lasso di tempo: Month 6

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Lasso di tempo: Year 1

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Lasso di tempo: Year 2

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Title: Muscle Cross-Sectional Area (CSA) of the quadriceps muscles (cm^2)
Lasso di tempo: Year 5

Cross-sectional area of the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Lasso di tempo: Day 0

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Lasso di tempo: Month 6

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Lasso di tempo: Year 1

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Lasso di tempo: Year 2

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Subcutaneous Adipose Tissue Thickness Over the Quadriceps (mm)
Lasso di tempo: Year 5

Thickness of the subcutaneous adipose tissue overlying the quadriceps muscles will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Lasso di tempo: Day 0

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Lasso di tempo: Month 6

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Lasso di tempo: Year 1

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Lasso di tempo: Year 2

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Medial Gastrocnemius (cm^2)
Lasso di tempo: Year 5

Cross-sectional area of the medial gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Lasso di tempo: Day 0

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Lasso di tempo: Month 6

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Lasso di tempo: Year 1

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Lasso di tempo: Year 2

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Muscle Cross-Sectional Area (CSA) of the Lateral Gastrocnemius (cm^2)
Lasso di tempo: Year 5

Cross-sectional area of the lateral gastrocnemius muscle will be measured by conventional B-mode ultrasound using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Day 0

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Month 6

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 1

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 2

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Quality Assessed by Shear Wave Elastography (kPa or m/s)
Lasso di tempo: Year 5

Muscle stiffness, reflecting muscle quality, will be assessed by Shear Wave Elastography (SWE) using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Day 0

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Month 6

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 1

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 2

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Microvascularization Assessed by Superb Microvascular Imaging (SMI) (%)
Lasso di tempo: Year 5

Muscle microvascularization will be assessed using Superb Microvascular Imaging (SMI), a Doppler-based technique that detects very low-velocity blood flow without contrast agent injection, using the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Quadriceps muscles Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Medial Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Day 0

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Day 0
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Month 6

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Month 6
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 1

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 1
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 2

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 2
Lateral Gastrocnemius Blood Flow Velocity Measured by Doppler Ultrasound (cm/s)
Lasso di tempo: Year 5

Muscle blood flow velocity will be measured using Doppler ultrasound with the Canon Aplio a ultrasound system (Model CUS-AA000, Canon Medical Systems Corporation).
Year 5

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

University Hospital, Clermont-Ferrand

Collaboratori

I-SITE Cap 20-25 project

Investigatori

  • Investigatore principale: Frédéric Costes, University Hospital, Clermont-Ferrand

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

27 agosto 2020

Completamento primario (Stimato)

26 agosto 2035

Completamento dello studio (Stimato)

26 agosto 2035

Date di iscrizione allo studio

Primo inviato

27 aprile 2020

Primo inviato che soddisfa i criteri di controllo qualità

4 maggio 2020

Primo Inserito (Effettivo)

5 maggio 2020

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

4 novembre 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

2 novembre 2026

Ultimo verificato

1 ottobre 2026

Maggiori informazioni

Termini relativi a questo studio

Parole chiave

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • RBHP 2019 COSTES
  • 2019-A01017-50 (Altro identificatore: 2019-A01017-50)

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

Sottoscrivi