Ventilatory Strategies After Cardiopulmonary Bypass Evaluated by Electrical Impedance Tomography
The Effects of Ventilatory Strategies on Pulmonary Function After Cardiopulmonary Bypass Evaluated by Electrical Impedance Tomography in Patients Undergoing Cardiac Surgery
Pulmonary complications after cardiac surgeries are common. It is one of the most crucial concerns of cardiac surgeons and anesthesiologists. These adverse events may vary from a mild respiratory dysfunction to acute respiratory distress syndrome (ARDS). One of the most public reasons of these complications is atelectasis that would result in hypoxia and pneumonia. Any of these adverse events rises the prevalence of morbidity and mortality. The chief inducing causes for atelectasis are CPB and dropped blood perfusion and ventilation of the lungs. The ventilation arrest is related with a high frequency of retained bronchial sections, local atelectasis, decrease in arterial O2 concentrations as a effect of surge in arteriovenous shunt, declined lung compliance, pulmonary edema and hence increased risk of nosocomial infections.
Electrical Impedance Tomography (EIT) is a non-invasive, radiation-free, real time bedside imaging modality, which provide the assessment of regional gas volume and lung ventilation. EIT has been experienced in quite a lot of animal and clinical applications including optimization of mechanical ventilator strategies and recognition of respiratory adverse events. Besides, EIT has been used to recognize ideal PEEP by detection of homogenous ventilation in non-dependent and dependent lung regions. Homogeneous ventilation is key for inhibition of ventilator-induced lung injury.
研究概览
详细说明
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Neihu Dist
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Taipei City、Neihu Dist、台湾、11490
- Department of Anesthesiology, Tri-Service General Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Age between 20-80 year-old
- Adult patients receiving elective cardiac surgery with hypothermic CPB
Exclusion Criteria:
- Patients were excluded if they had complicating comorbidities, such as chronic hepatic or renal insufficiency, acute cardiopulmonary failure requiring mechanical ventilation, intra-aortic balloon pump, or extracorporeal membrane oxygenation
学习计划
研究是如何设计的?
设计细节
- 主要用途:卫生服务研究
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
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假比较器:Group R
IMV(intermittent mandatory ventilation) Regular Ventilation with Tidal volume with 7ml/ kg (Predicted body weight)
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Ventilation strategies with 4 kinds of ventilator mode since weaning cardiopulmonary bypass (CPB), Four group were control EtCO2 between 35~45mmHg by adjusting respiratory rate, EIT Measurements were performed under supine position
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实验性的:Group RP
Regular Ventilation with Tidal volume with 7ml/ kg (Predicted body weight) + PEEP : 6 cm H2O
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Ventilation strategies with 4 kinds of ventilator mode since weaning cardiopulmonary bypass (CPB), Four group were control EtCO2 between 35~45mmHg by adjusting respiratory rate, EIT Measurements were performed under supine position
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实验性的:Group RI
Regular Ventilation with Tidal volume with 7ml/ kg (Predicted body weight) + Reverse IE ratio ventilation( I:E=1:1)
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Ventilation strategies with 4 kinds of ventilator mode since weaning cardiopulmonary bypass (CPB), Four group were control EtCO2 between 35~45mmHg by adjusting respiratory rate, EIT Measurements were performed under supine position
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实验性的:Group RPI
Regular Ventilation with Tidal volume with 7ml/ kg (Predicted body weight) + PEEP : 6 cm H2O + Reverse IE ratio ventilation( I:E=1:1)
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Ventilation strategies with 4 kinds of ventilator mode since weaning cardiopulmonary bypass (CPB), Four group were control EtCO2 between 35~45mmHg by adjusting respiratory rate, EIT Measurements were performed under supine position
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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The correlation between Different ventilation mode and the relevant value of EIT
大体时间:since weaning cardiopulmonary bypass (CPB) to the end of surgery
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Compare the correlation between Different ventilation mode and the relevant value of EIT in the population of open heart surgery patient
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since weaning cardiopulmonary bypass (CPB) to the end of surgery
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The demographic characteristics and relevant value of EIT
大体时间:since weaning cardiopulmonary bypass (CPB) to the end of surgery
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Campare the demographic characteristics and relevant value of EIT in the population of open heart surgery patient
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since weaning cardiopulmonary bypass (CPB) to the end of surgery
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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If the different ventilation mode setting can improve clinical outcome
大体时间:since weaning cardiopulmonary bypass (CPB) to the end of surgery
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Identify the different ventilation mode setting in open heart surgery patient if can improve clinical care benifit.
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since weaning cardiopulmonary bypass (CPB) to the end of surgery
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The correlation between heart function & oxygenation and different ventilation mode
大体时间:since weaning cardiopulmonary bypass (CPB) to the end of surgery
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Survey the correlation between heart function & oxygenation and different ventilation mode
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since weaning cardiopulmonary bypass (CPB) to the end of surgery
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- Ventilatory with EIT post CPB
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
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