Construction of Special Disease Cohort Database and Biological Sample Holographic Database of Severe Pneumonia
The incidence rate and mortality of lung infection are high worldwide. It is a common and frequently occurring disease which seriously threatens human health. Severe pneumonia accounts for 18-36% of all pneumonia. Severe pneumonia has caused serious economic and medical burden. Therefore, it is urgent to carry out the real-world cohort study of severe pneumonia. Big data and sample library will provide useful clinical guidance and scientific research reserves for clinicians. Through further research, we can improve the treatment success rate and reduce the mortality.
The purpose of this study is to provide reliable biological samples and related data information for the relevant basic and clinical trials in the field of severe pneumonia by carrying out the construction of special disease cohort database and biological sample holographic database, and to establish a long-term sharing platform for the transformation of research results into clinical practice, improve the prognosis of severe pneumonia,and provide the evidence for improving the diagnosis and treatment of severe pneumonia suitable for China's national conditions.
研究概览
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名:Jieming Qu, MD,PhD
- 电话号码:+86-21-64370045
- 邮箱:jmqu0906@163.com
学习地点
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Shanghai
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Shanghai、Shanghai、中国、200025
- 招聘中
- Ruijin Hospital, Medical School of Shanghai Jiaotong University
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接触:
- Jieming Qu, MD, PhD
- 电话号码:86-21-64370045
- 邮箱:jmqu0906@163.com
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Recent cough, expectoration or aggravation of original respiratory diseases, with or without purulent sputum / chest pain / dyspnea / hemoptysis
- Fever
- Signs of pulmonary consolidation and / or moist rales
- Peripheral blood leukocytes >10×10^9/L or less than 4×10^9/L, with or without nucleus shifting to the left.
- New patchy infiltration, consolidation of lobes / segments, ground glass opacity or interstitial changes, with or without pleural effusion on chest imagings
- Positive etiological examination
- Age > 18 years old
- Need mechanical ventilation; septic shock need vasoactive drug treatment. Meet one of them.
- ① respiratory rate ≥ 30 beats / min; ② oxygenation index (PaO2 / FiO2) ≤ 250; ③ multilobar infiltration; ④ disturbance of consciousness / disorientation; ⑤ azotemia (BUN ≥ 20mg / dl); ⑥ cytopenia (WBC < 4.0 × 109 / L); ⑦ thrombocytopenia (platelet < 10.0 × 109 / L); Ⅷ low body temperature (T < 36 ℃); Ⅸ hypotension, requiring strong fluid resuscitation. Meet the above three requirements at the same time.
Exclusion Criteria:
● Cannot understand and / or implement the investigation protocol.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
|---|
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severe pneumonia
Patients with severe pneumonia
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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clinical outcome of patients with severe pneumonia
大体时间:day 3, day 7, day 14, day 30, day 180.
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The pneumonia is cured or improved, or the treatment of pneumonia is invalid, or the patient is dead.
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day 3, day 7, day 14, day 30, day 180.
|
合作者和调查者
调查人员
- 首席研究员:Jieming Qu, MD,PhD、Ruijin Hospital
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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