The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection
2021年6月28日 更新者：Fatih Sultan Mehmet Training and Research Hospital
The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection: A Retrospective Study
Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections.
Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.
研究概览
详细说明
In this retrospective study 300 patients diagnosed with COVID19 were included.
According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3).
The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal.
Patients' age, gender, comorbid diseases and laboratory values were recorded
研究类型
观察性的
注册 (实际的)
300
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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Istanbul、火鸡、34752
- Gulcan Ozturk
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
16年 至 97年 (孩子、成人、年长者)
接受健康志愿者
不适用
有资格学习的性别
全部
取样方法
非概率样本
研究人群
COVID19 infection positive patients whose polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months
描述
Inclusion Criteria:
- The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months
Exclusion Criteria:
- Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Experimental: Mild Clinical Group
patients showing mild clinical symptoms without pneumonia.
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Laboratory measurement of patient's inflammatory status in unit of % and mg/dl
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl
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Experimental: Moderate Clinical Group
patients with fever, other respiratory symptoms, and pneumonia findings based on radiological imaging
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Laboratory measurement of patient's inflammatory status in unit of % and mg/dl
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl
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Experimental: severe/critical clinical group
severe one of these as follows; patients with hypoxia (≤93% oxygen saturation), respiratory distress (RR >30 times per minute), partial pressure of arterial blood oxygen (PaO 2 )/the fraction of inspired oxygen (FiO 2 ) ≤ 300 mmHg, patients whose chest imaging shows that lung damage develops significantly within 24 to 48 hours, or critical one of these as follows; respiratory failure requiring mechanical ventilation, signs of septic shock with multiple organ failure requiring intensive care unit admission.
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Laboratory measurement of patient's inflammatory status in unit of % and mg/dl
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
25-OH vitamin D
大体时间：1 day
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laboratory measurement in unit of ng/ml
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1 day
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White blood cell count
大体时间：1 day
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laboratory measurement in unit of x103/uL
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1 day
|
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neutrophil count
大体时间：1 day
|
laboratory measurement in unit of x103/uL
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1 day
|
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neutrophil ratio
大体时间：1 day
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laboratory measurement in unit of %
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1 day
|
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lymphocyte count
大体时间：1 day
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x103/uL
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1 day
|
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lymphocyte ratio
大体时间：1 day
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laboratory measurement in unit of %
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1 day
|
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platelet count
大体时间：1 day
|
laboratory measurement in unit of x103/uL
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1 day
|
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hemoglobin count
大体时间：1 day
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laboratory measurement in unit of g/dl
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1 day
|
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C-reactive protein levels
大体时间：1 day
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laboratory measurement in unit of mg/dL
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1 day
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neutrophil to lymphocyte ratio
大体时间：1 day
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laboratory measurement in unit of %
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1 day
|
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platelet to lymphocyte ratio
大体时间：1 day
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laboratory measurement in unit of %
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1 day
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020 Oct;13(10):1373-1380. doi: 10.1016/j.jiph.2020.06.021. Epub 2020 Jun 20.
- Ali N. Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19. J Med Virol. 2020 Nov;92(11):2409-2411. doi: 10.1002/jmv.26097. Epub 2020 Jun 9. No abstract available.
- Khemka A, Suri A, Singh NK, Bansal SK. Role of Vitamin D Supplementation in Prevention and Treatment of COVID-19. Indian J Clin Biochem. 2020 Oct;35(4):502-503. doi: 10.1007/s12291-020-00908-3. Epub 2020 Jul 30. No abstract available.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2020年7月1日
初级完成 (实际的)
2020年8月1日
研究完成 (实际的)
2020年8月1日
研究注册日期
首次提交
2021年6月6日
首先提交符合 QC 标准的
2021年6月28日
首次发布 (实际的)
2021年6月30日
研究记录更新
最后更新发布 (实际的)
2021年6月30日
上次提交的符合 QC 标准的更新
2021年6月28日
最后验证
2021年6月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.