Cellular microRNA Signatures in Multiple Sclerosis (SEP-MIR)
A limited number of studies on microRNA expression variation in immune cells have been reported in relapsing-remitting multiple sclerosis (RRMS). These studies have been performed mostly on a small scale and on whole blood mononuclear cells (PBMC).
In a number of cases, RRMS progresses to a severe secondary neurodegenerative form. In this context, it is important to look for biomarkers that could indicate the pathogenic activity of certain immune cell subpopulations.
研究概览
详细说明
SEP-MIR is a prospective, single-center, descriptive study.
Participants will be recruited among adult patients with RRMS coming for a follow-up consultation in the Neurology Department, Nervous System Diseases Pole, at the hôpital Pitié - Salpêtrière (Paris).
As this is a descriptive study, the recruitment of 20 participants (10 patients with relapsing-remitting MS and 10 patients with relapsing-remitting MS) should meet the objectives of this study.
A 50 ml blood sample will be obtained from each participant and several clinical data regarding their pathology will be collected.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Frédérique Michel, PhD
- 电话号码：+33 1 45 68 86 38
- 邮箱：frederique.michel@pasteur.fr
学习地点
-
-
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Paris、法国、75013
- Hôpital La Pitié - Salpêtrière
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接触：
- Thomas Roux, MD
- 电话号码：+33 1 42 16 17 51
- 邮箱：thomas.roux@aphp.fr
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Caucasian population
- Female and male individuals with an f/m ratio of 2-4/1
- Individuals with RRMS according to the 2010 McDonald criteria for less than 15 years, with EDSS 1-6, in remission or relapse
- Participant's condition compatible with a maximum of 50 ml of blood collection
- Persons affiliated with a social security plan.
Exclusion Criteria:
- MS treatment with steroidal anti-inflammatory drugs, immunomodulators or immunosuppressants within 2 months prior to blood collection
- Persons with acute and chronic infectious disease, autoimmune/inflammatory disease or cancer other than MS
- Pregnant or lactating women
- Be under guardianship,
- Be deprived of liberty by judicial or administrative decision, or be under legal protection.
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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其他：Untreated RRMS patients
Untreated RRMS patients with a 50 ml blood sample during their routine care
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50 ml blood sampling for genetic analysis (expression profiles of microRNAs)
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
microRNA expression profiles in immune cell populations from RRMS patients
大体时间：2 years
|
RNAseq and/or Nanostring sequencing of PBMCs from RRMS patients
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2 years
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
microRNA expression profiles in unstimulated and stimulated CD4+ T cell populations ex vivo from RRMS patients
大体时间：2 years
|
RNAseq and/or Nanostring sequencing of unstimulated and stimulated CD4+ T cell populations ex vivo from RRMS patients
|
2 years
|
|
microRNA expression profiles in monocytes from RRMS patients
大体时间：2 years
|
RNAseq and/or Nanostring sequencing of monocytes from RRMS patients
|
2 years
|
合作者和调查者
调查人员
- 研究主任：Frédérique Michel, PhD、Institut Pasteur
研究记录日期
研究主要日期
学习开始 (预期的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- 2021-044
- 2021-A02983-3 (其他标识符：ID-RCB)
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