此页面是自动翻译的，不保证翻译的准确性。请参阅英文版对于源文本。

Gingival Crevicular Fluid Levels of Prolactin Hormone in Obese Patients With Stage ii and Iii Periodontitis Before and After Non-surgical Periodontal Therapy

2026年5月3日更新者：Alexandria University

Gingival Crevicular Fluid Levels of Prolactin Hormone in Obese Patients With Stage ii and Iii Periodontitis Before and After Non-surgical Periodontal Therapy (a Comparative Clinical Study)

Obesity and periodontitis are among the most common chronic disorders affecting the world population, while Prolactin (PRL) is a neuroendocrine hormone that within the physiological range stimulates bone formation while mild to marked increase in its level induces bone resorption and inhibits bone formation.

Aim of the study: study aims to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF) in obese (O) patients with and without stage II and III periodontitis (P). Further, to evaluate the effect of non-surgical periodontal therapy on these levels compared to controls.

研究概览

地位

完全的

条件

干预/治疗

研究类型

介入性

注册 (实际的)

阶段

不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

埃及
- - Alexandria、埃及
    - Outpatient Clinic of Periodontology and Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

成人

接受健康志愿者

不

描述

Inclusion Criteria:

Body mass index (more than 29.9 kg/m2).
stage II and III periodontitis

Exclusion Criteria:

Pregnancy or lactation.
Any known systemic disease other than obesity
Previous periodontal treatment (surgical or non-surgical) in last 6 months;
Antibiotics in the past 3 months.
Smoking

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

主要用途：治疗
分配：非随机化
介入模型：并行分配
屏蔽：无（打开标签）

手臂数量

武器和干预

参与者组/臂	干预/治疗
实验性的：Patients with peridontal disease	其他：Obese patients with stage II and III periodontitis and non surgical peridontal therapy Patients had BMI of more than 29.9 kg/m2. charaterized by Stage II periodontitis with clinical attachment loss of 3-4 mm, radiographic bone loss confined to the coronal third, and no history of tooth loss due to infection and Stage III signifies severe destruction with attachment loss of more th toan or equal 5 mm, bone loss extending into the middle or apical third of the root, and potential tooth loss of up to four teeth. Patients will undergo full mouth scaling and root planning for two sessions
有源比较器：Patients without peridontal disease	其他：obese patients with healthy periodontium with no intervention Patients had BMI of more than 29.9 kg/m2 but with healthy peridontium

参与者组/臂

干预/治疗

实验性的：Patients with peridontal disease

其他：Obese patients with stage II and III periodontitis and non surgical peridontal therapy

Patients had BMI of more than 29.9 kg/m2. charaterized by Stage II periodontitis with clinical attachment loss of 3-4 mm, radiographic bone loss confined to the coronal third, and no history of tooth loss due to infection and Stage III signifies severe destruction with attachment loss of more th toan or equal 5 mm, bone loss extending into the middle or apical third of the root, and potential tooth loss of up to four teeth. Patients will undergo full mouth scaling and root planning for two sessions

有源比较器：Patients without peridontal disease

其他：obese patients with healthy periodontium with no intervention

Patients had BMI of more than 29.9 kg/m2 but with healthy peridontium

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
change in clinical attachment level 大体时间：Baseline and 3 months	Clinical attachment level (CAL) using a Williams probe (which manufactured in Europe from AISI 304 Stainless steel) from a fixed reference point on the crown to the base of the pocket.	Baseline and 3 months
change in GCF levels of prolactin hormone 大体时间：Baseline and 3 months	Gingival crevicular fluid sample will be obtained from the buccal aspects of two interproximal sites in teeth that will have the highest signs of inflammation and attachment loss	Baseline and 3 months

次要结果测量

结果测量	措施说明	大体时间
change in Probing depth 大体时间：Baseline and 3 months	measured from the margin of the gingiva to the base of the pocket until slight resistance is encountered using a Williams probe (which manufactured in Europe from AISI 304 Stainless steel).	Baseline and 3 months
change in gingival index 大体时间：Baseline and 3 months	Gingival Index evaluates the severity of gingivitis by scoring the color, consistency, and bleeding tendency of the soft tissues on a scale of 0 to 3, where a score of 2 indicates bleeding upon probing and a 3 signifies spontaneous bleeding	Baseline and 3 months
change in plaque index 大体时间：Baseline and 3 months	Plaque Index focuses exclusively on the thickness of the microbial biofilm at the gingival margin, ranging from a score of 1, where plaque is only detectable by running a probe across the surface, to a score of 3, characterized by an abundance of visible soft matter.	Baseline and 3 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Alexandria University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2024年10月1日

初级完成 (实际的)

2025年6月30日

研究完成 (实际的)

2025年6月30日

研究注册日期

首次提交

2026年4月18日

首先提交符合 QC 标准的

2026年5月3日

首次发布 (实际的)

2026年5月6日

研究记录更新

最后更新发布 (实际的)

2026年5月6日

上次提交的符合 QC 标准的更新

2026年5月3日

最后验证

2026年4月1日

Gingival Crevicular Fluid Levels of Prolactin Hormone in Obese Patients With Stage ii and Iii Periodontitis Before and After Non-surgical Periodontal Therapy