A Prospective, Randomized, Blind, Controlled Multicenter Clinical Study Comparing the Effectiveness of Preventive Ventricular Arrhythmia Ablation on the Prognosis After Left Ventricular Assist Device (LVAD) Surgery. (PAVA-LVAD)
研究概览
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习地点
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Anhui
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Hefei、Anhui、中国
- 5thBuilding, 9thFloor, High-tech Campus of the First Affiliated Hospital of Anhui Medical University
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参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
描述
Inclusion Criteria:
- 1.voluntary and with the provision of an informed consent form 2.males or females aged 18 years or older 3.all patients with acute and critical or chronic advanced heart failure who have failed to respond to standardized oral medication and are scheduled to undergo artificial heart implantation surgery
Exclusion Criteria:
1.The left ventricular assist system is prohibited for patients who cannot tolerate anticoagulant therapy or who are allergic to anticoagulant treatment.
2.Doctors with sufficient experience will make a comprehensive judgment based on the patient's physical condition, body surface area, and the anatomical-related conditions of the planned implantation site, and determine those who are not suitable for the implantation procedure.
3.Pregnant women. 4.Systemic active infection. 5.Patients in a state of brain death. 6.Irreversible severe liver or kidney dysfunction. 7.Having a history of severe chronic obstructive pulmonary disease (COPD) or restrictive lung disease.
8.primary pulmonary hypertension. 9.Having a confirmed and untreated history of abdominal or thoracic aortic aneurysm with a diameter greater than 5 cm.
10.Patients with severe atherosclerotic plaques in the aorta. 11.Having mental disorders/impairments, irreversible cognitive dysfunction, or social-psychological problems, which makes it possible for the patient to fail to comply with the application management regulations of the implanted left ventricular assist device.
12.Preoperative conditions included end-stage organ failure, such as renal failure (requiring hemodialysis), liver failure, respiratory failure; and concurrent malignant tumors or any severe accompanying diseases with an expected lifespan of less than 3 years.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：preventive ablation group
for patients undergoing LVAD surgery while also undergoing prophylactic ablation of ventricular arrhythmias at the same time
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for patients undergoing LVAD surgery while also undergoing prophylactic ablation of ventricular arrhythmias at the same time
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|
无干预：the control group without any treatment
no intervention measures
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
persistent ventricular tachycardia / ventricular fibrillation
大体时间：Continuous electrocardiogram monitoring for 30 days after surgery
|
Electrocardiogram monitoring was conducted daily for the patients 30 days after the surgery.
Data were uploaded daily and the frequency of arrhythmia occurrences was statistically analyzed.
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Continuous electrocardiogram monitoring for 30 days after surgery
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|
all-cause mortality
大体时间：Within 30 days after the operation
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Conduct a 30-day follow-up visit for the patients, and collect the time and cause of death.
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Within 30 days after the operation
|
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mechanical thrombus
大体时间：Within 30 days after the operation
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Electrocardiogram monitoring was performed daily on the patients 30 days after the surgery.
When thrombosis occurred, the left heart assist device would give an alarm to alert.
In some cases, autopsy could be conducted to obtain the results.
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Within 30 days after the operation
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right heart failure
大体时间：Within 30 days after the operation
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Conduct a 30-day follow-up visit for the patients, and collect the time and cause of right heart failure.
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Within 30 days after the operation
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
all-cause mortality
大体时间：semi-annually, for a total of three years
|
Patients are followed up in the outpatient department or by phone every six months to collect death-related records such as death certificates and discharge summaries.
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semi-annually, for a total of three years
|
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mechanical thrombus
大体时间：semi-annually, for a total of three years
|
The artificial heart device implanted in the patient will continuously monitor.
When a thrombosis occurs, the left heart assist device will alert and remotely contact the medical team.
In some cases, this information can be obtained through autopsy after death.
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semi-annually, for a total of three years
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stroke
大体时间：semi-annually, for a total of three years
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Patients are followed up in the outpatient department or by phone every six months, and the necessary medical history records, imaging reports (such as head CT or MRI), and other original materials are collected.
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semi-annually, for a total of three years
|
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Hospitalization or emergency visit due to heart failure
大体时间：semi-annually, for a total of three years
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Patients are followed up in the outpatient department or by phone every six months, and the necessary medical history records are collected, including symptoms such as shortness of breath and signs such as lower extremity edema, measurement of brain natriuretic peptide levels, and treatment with diuretics, etc.
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semi-annually, for a total of three years
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heart transplantation
大体时间：semi-annually, for a total of three years
|
Patients are followed up in the outpatient department or by phone every six months, and the necessary medical history records are collected.
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semi-annually, for a total of three years
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合作者和调查者
合作者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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