Epicardial Fat Tissue and Cardiometabolic Risk in Russian and Asian Populations (EPIGRAPH)
Epicardial Fat Tissue Assessed by Echocardiography in Russian and Asian Populations: Association With Chronic Non-Communicable Diseases and Risk Factors
Visceral obesity is a well-established risk factor for the development of chronic non-communicable diseases (NCDs). Epicardial fat tissue (EFT) is located on the surface of the myocardium and may directly affect cardiac function and contribute to structural and functional remodeling.
According to the literature, increased EFT thickness is associated with a wide range of NCDs, disease severity, and prognosis.
The aim of this study is to investigate the associations between EFT thickness and clinical and anamnestic parameters, as well as to evaluate the prognostic value of this parameter in patients aged 50-70 years from the Russian Federation, Kazakhstan, Uzbekistan, and Kyrgyzstan.
研究概览
详细说明
The study is designed to:
- Assess physical examination findings, laboratory parameters, and comorbidities;
- Evaluate transthoracic echocardiography parameters;
- Analyze associations between EFT thickness and clinical and anamnestic characteristics;
- Determine threshold values of EFT thickness associated with structural and functional myocardial remodeling;
- Conduct follow-up via telephone to assess study endpoints;
- Evaluate the prognostic value of EFT thickness with respect to a composite endpoint.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Olga Dzhioeva, MD, Associate Professor
- 电话号码：+79166141821
- 邮箱：odzhioeva@gnicpm.ru
研究联系人备份
- 姓名：Elizaveta Rogozhkina, PhD
- 电话号码：+79371047331
- 邮箱：lizarogozkina@gmail.com
学习地点
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Moscow、俄罗斯
- 招聘中
- National Medical Research Center for therapy and preventive medicine
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接触：
- Olga Dzhioeva, MD, Associate Professor
- 电话号码：+79166141821
- 邮箱：odzhioeva@gnicpm.ru
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参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Patients aged 50-70 years undergoing transthoracic echocardiography in inpatient or outpatient settings;
- Ability and willingness to provide informed consent.
Exclusion Criteria:
- Refusal to sign informed consent;
- Inability to perform transthoracic echocardiography or poor image quality;
- Severe psychiatric disorders.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Observational cohort
Patients aged 50-70 years undergoing transthoracic echocardiography (TTE) in inpatient or outpatient
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Composite endpoint - all-cause mortality - hospitalizations - major adverse cardiovascular events (MACE)
大体时间：12 months
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12 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.