Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients (PRE-COCO)

Inclusion Criteria:

• Age ≥ 18 years
• Patients who have been on haemodialysis for at least 6 months
• Elevated troponin levels > 40 ng/L in a sample taken whilst the patient was in a stable condition, dated within the last 3 months
• Patients capable of understanding the protocol and who have given their written informed consent to participate in the research
• Patients registered with the National Health Service or eligible for it

Exclusion Criteria:

• Age > 90 years
• Patient undergoing daily home haemodialysis
• Symptomatic stage 3 or 4 peripheral arterial disease
• Severe hypertrophic cardiomyopathy (genetic or amyloid)
• Severe valvular heart disease leading to left ventricular remodelling (surgically contraindicated severe aortic stenosis, severe mitral regurgitation, severe aortic regurgitation)
• Hospitalisation for decompensation/acute heart failure within the last month
• Acute coronary syndrome and any coronary artery disease requiring angioplasty and/or stent implantation within the last 3 months
• Contraindication to METHERGIN and DOBUTAMINE
• Patients participating in another clinical research protocol that may affect the research objectives
• Patients already included in the study
• Patients under guardianship, curatorship or deprived of their liberty
• Patients under an activated future protection order
• Patients under family authorisation
• Patient under judicial protection
• Pregnant patient