Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery
Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by increasing right ventricular afterload through pulmonary vasoconstriction and elevated pulmonary arterial pressures. This phenomenon leads to increased right ventricular workload, causing dilation, decreased contractility, and ultimately right heart failure. The study aims to evaluate the effect of respiratory acidosis on right ventricular function after cardiac surgery.
研究概览
详细说明
Post hoc analysis of data from two separate studies previously approved by the Research Ethics Board NCT05886413 and NCT06826794. A stratification according to respiratory acidosis defined by a pH <7.35 with PaCO₂ >45mmHg on the first arterial blood gas analysis at the intensive care unit arrival will be done.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Etienne Couture
- 电话号码：1-418-656-8711
- 邮箱：etienne.couture.3@ulaval.ca
学习地点
-
-
Quebec
-
Québec、Quebec、加拿大、G1V4G5
- 招聘中
- Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval
-
接触：
- Etienne Couture
- 电话号码：418-656-8711
- 邮箱：etienne.couture.3@ulaval.ca
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Adult patients who underwent cardiac surgery mechanically ventilated in controlled mode, and had an arterial blood gas within the first hour following admission.
描述
Inclusion Criteria:
- Previously included and complete study NCT05886413 or NCT06826794
Exclusion Criteria:
- Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output
- Absence of arterial blood gas on arrival to the intensive care unit
学习计划
研究是如何设计的？
设计细节
- 观测模型：COHORT
- 时间观点：RETROSPECTIVE
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Retrospective cohort
Completed study. Adult patients who underwent cardiac surgery were included if they were admitted to the intensive care unit immediately after surgery, mechanically ventilated in controlled mode, and had an arterial blood gas within the first hour following admission. |
No intervention |
|
Prospective cohort
Completed study. Adult patient included on open-label randomized study, comparing clinician-chosen initial mechanical ventilation parameters to those recommended by an algorithm immediately after ICU admission. |
No intervention |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Right ventricular function per central hemodynamic assessment
大体时间：At intensive care unit admission - within the first 4 hours
|
Calculation of different predictor: Cardiac index, PAPi (pulmonary artery pulse pressure over central venous pressure) , RVSWI ((mean pulmonary artery pressure- central venous pressure) X stroke volume index X 0.0136) and RV-CPO |
At intensive care unit admission - within the first 4 hours
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Intensive care unit length of stay
大体时间：Up to 28 days
|
Intensive care unit admission through Intensive care unit discharge |
Up to 28 days
|
|
Mechanical ventilation duration
大体时间：Day 28
|
Time spent with invasive mechanical ventilation between intensive care unit admission and hospital discharge |
Day 28
|
|
Vasopressor duration
大体时间：Day 28
|
Duration of vasopressor or inotrope administration |
Day 28
|
|
Acute renal failure
大体时间：Day 28
|
Rate of acute renal failure during coronary unit length of stay. Renal failure will be defined according to the usual criteria, i.e., an increase of >27 umol/L creatinine in 48 hours or 1.5x over the baseline |
Day 28
|
|
Mortality
大体时间：Day 28
|
Mortality in intensive care unit |
Day 28
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2027-4604
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
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