Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up (GlioConnect)
Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of Diffusion Tensor Imaging (DTI) and Resting State Functional MRI (Rs-fMRI) to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up
The aim of this study is to determine whether the diffuse cerebral metabolic disturbances observed in glioblastoma are exclusively linked to the direct and indirect effects of tumor infiltration (particularly structural disconnection), or whether they also reflect a more global alteration of neurometabolic and neurovascular coupling mechanisms.
This approach thus aims to better understand the pathophysiological basis of cognitive impairment in glioblastoma and to characterize the impact of the disease at the level of brain networks.
研究概览
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Claire VIT
- 电话号码：+33 (0)388258529
- 邮箱：promotion-rc@institut-strauss.fr
研究联系人备份
- 姓名：Manon VOEGELIN
- 电话号码：+33 (0)368339523
- 邮箱：promotion-rc@institut-strauss.fr
学习地点
-
-
-
Strasbourg、法国、67033
- Institut public de cancérologie Strauss Europe
-
首席研究员：
- Izzie-Jacques NAMER, MD, PhD
-
接触：
- Claire VIT
- 电话号码：+33 (0)388258529
- 邮箱：promotion-rc@institut-strauss.fr
-
接触：
- Manon VOEGELIN
- 电话号码：+33 (0)368339523
- 邮箱：promotion-rc@institut-strauss.fr
-
-
参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
描述
Inclusion Criteria:
- Adult patients
- Patients with glioblastoma
Patients treated in the Nuclear Medicine & Molecular Imaging Department of the Strauss Institute for PET/MRI scans for:
- Preoperative metabolic evaluation of a brain-expanding lesion
Exclusion Criteria:
- Contraindications to MRI
- Minor or incapacitated adult
- Patient deprived of liberty
- Patient under legal guardianship
- Patient unable to consent
- Pregnant or breastfeeding woman
学习计划
研究是如何设计的？
设计细节
- 主要用途：其他
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
其他：Patients with glioblastoma treated in the Department of Nuclear Medicine & Molecular Imaging
|
fluorodeoxyglucose (Fluor18) (18F-FDG) PET/MRI with additional DTI and rs-fMRI sequences correlation with neuropsychological tests
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance before surgery
大体时间：Before surgery
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Before surgery
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance after surgery
大体时间：After surgery, through the study, i.e. for a maximum of 2 years
|
After surgery, through the study, i.e. for a maximum of 2 years
|
合作者和调查者
调查人员
- 首席研究员：Izzie-Jacques NAMER, MD, PhD、Institut public de cancérologie Strauss Europe
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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