Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy. (DYNFDGTEP)
Interest of Early Dynamic Analysis of [18F]-FDG PET Images in the Differential Diagnosis Between Recurrence and Radionecrosis in Brain Metastases.
Various treatment options are available for brain metastases, depending on factors such as lesion site or number lesions. Radiotherapy is a commonly used treatment. Following stereotactic radiotherapy for brain metastases, a potential complication, namely brain radionecrosis, can occur subsequently. It is essential to differentiate between this radionecrosis and lesion recurrence in order to determine the appropriate treatment approach. Contrast-enhanced magnetic resonance imaging (MRI) is the most widely used technique for monitoring brain metastases. Therefore, patients undergo routine MRI at 3 months and during subsequent follow-ups, but if the lesion evolve and if distinguishing between recurrence and radionecrosis is challenging, an [18F]-FDG PET scan is then prescribed by oncologists or radiotherapists during follow-up consultations. As part of the standard patient management protocol, a 10-minute image acquisition begins after a 45-60 minutes wait following the radiotracer injection. A second image acquisition is then conducted 3-4 hours later. For both acquisitions, a low-dose X-ray scanner is synchronously coupled to allow attenuation correction of the PET images.
Patient for whom a [18F]-FDG PET cerebral examination has been prescribed as part of the usual management of brain metastases will be eligible to the protocol. If the patient agrees to participate, an early imaging session is initiated immediately upon radiotracer injection, lasting 15 minutes in addition to the standard acquisition protocol.
研究概览
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Antoine GIRARD
- 电话号码：33+3 22 45 03 81
- 邮箱：Girard.Antoine@chu-amiens.fr
学习地点
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Amiens、法国
- 招聘中
- CHRU Amiens
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副研究员：
- Alexandre COUTTE, MD
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副研究员：
- Mathieu BOONE, MD
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接触：
- Antoine GIRARD, MD
- 电话号码：33+3 22 45 03 81
- 邮箱：Girard.Antoine@chu-amiens.fr
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副研究员：
- Ismaël NEJJAR, MD
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副研究员：
- Marc-Etienne MEYER, Pr
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副研究员：
- Chalabia FERGANI, MD
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副研究员：
- Florent Hives, MD
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参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Patient referred for cerebral [18F]-FDG PET examination prescribed as part of his usual medical care for brain metastasis.
- Age ≥ 18 years old
- Affiliation to a social security program
- Ability of the subject to understand and express his consent
Exclusion Criteria:
- Age under 18 years old
- Person under guardianship or curatorship
- Pregnant or breastfeeding woman
- Primary brain tumors
- Brain metastases from renal, thyroid or other cancers known to have low avidity for [18F]-FDG
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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ratio between lesion maximum activity and controlateral healthy tissue activity
大体时间：day1
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Value of the measurement of the ratio of the maximum activity within the lesion to the average activity within the region of interest of the contralateral healthy tissue.
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day1
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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association between kinetic uptake parameters and diagnosis
大体时间：12 months
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association between kinetic uptake parameters from compartmental models and the differential diagnosis of radionecrosis and recurrence of brain metastases treated by radiotherapy
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12 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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