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Non-Pharmacological Factors on Spinal Block Duration

2026年6月18日更新者：Taksim Egitim ve Arastirma Hastanesi

Analysis of Non-pharmacological Factors on Spinal Anaesthesia Block Duration

The aim of this study is to evaluate the effects of non-pharmacological factors-such as age, sex, body mass index, paraspinal muscle mass, vertebral canal anatomy, patient positioning, and injection technique-on the duration of sensory and motor block in patients undergoing spinal anesthesia, and to investigate the potential relationships between these factors and block duration.

研究概览

地位

招聘中

条件

Paraspinal Muscle Mass and Spinal Anaesthesia

干预/治疗

程序：spinal anaesthesia

详细说明

It is well known that the level of sensory and motor block following spinal anesthesia varies among individuals. This variability is not only related to the dose of local anesthetic but has also been reported to be associated with patient-related non-pharmacological factors. In particular, a relationship has been demonstrated between body mass index (BMI) and both the level and duration of spinal block, with higher block levels and prolonged block duration observed in patients with increased BMI. This phenomenon is thought to be associated with epidural venous distension due to increased intra-abdominal pressure and a reduction in subarachnoid cerebrospinal fluid (CSF) volume. A decrease in CSF volume may facilitate greater cephalad spread of intrathecal local anesthetic agents, thereby prolonging block duration.

Paraspinal muscle mass is also an important anatomical parameter that may influence intra-abdominal pressure and epidural space compliance, and thus may play a determining role in the spread of spinal anesthesia. However, although several studies have investigated the relationship between BMI and body composition and spinal block characteristics, the number of clinical studies directly evaluating the association between ultrasonographically measured paraspinal muscle mass and spinal anesthesia block duration remains limited. Therefore, ultrasonographic measurement of paraspinal muscle thickness may serve as a potential predictor of spinal block duration.

研究类型

观察性的

注册 (估计的)

140

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

姓名：Leyla Sivacigil, MD
电话号码：905065983478
邮箱：veralleyla@hotmail.com

研究联系人备份

姓名：Guray Demir, Proffesor
电话号码：90 5052113989
邮箱：guraydemir@gmail.com

学习地点

土耳其（türkiye）
- - Istanbul、土耳其（türkiye）、34000
    - 招聘中
    - Taksim Training and Research Hospital
    - 接触：
      
      Leyla Sivacigil, MD
      
      电话号码：905065983478
      
      邮箱：veralleyla@hotmail.com
    - 首席研究员：
      
      Leyla Sivacigil, MD
    - 接触：
      
      Guray Demir, Proffesor
      
      电话号码：905052113989
      
      邮箱：guraydemir@gmail.com

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

成人
年长者

接受健康志愿者

不

取样方法

概率样本

研究人群

Patients aged 18-80 years, male and female, classified as ASA physical status I-III, and scheduled for elective lower abdominal surgery.

描述

Inclusion Criteria:

Patients aged 18-80 years
ASA physical status I-III
Patients scheduled for elective lower abdominal surgery.

Exclusion Criteria:

Patient refusal to participate
Coagulopathy
Use of medications or substances known to impair coagulation
Pregnancy, sepsis
Shock
Severe aortic or mitral regurgitation
Peripheral vascular disease
Increased intracranial pressure
Mental disorders
Spinal column deformity
History of previous spinal surgery.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Paraspinal mass measurement with ultrasound. 大体时间：Pre-operative	Ultrasonographic measurement of paraspinal muscle thickness (cm) and its association with duration of spinal block will be investigated.	Pre-operative

次要结果测量

结果测量	措施说明	大体时间
The spread of the spinal block 大体时间：Perioperative/Periprocedural	The speed of the sensational block will be measured after spinal anaesthesia performed. Time(minute) will be recorded when T10 level sensational block is achieved.	Perioperative/Periprocedural

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Taksim Egitim ve Arastirma Hastanesi

调查人员

首席研究员：Leyla Sivacigil、Taksim Training and Research Hospital

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2026年6月16日

初级完成 (估计的)

2026年12月1日

研究完成 (估计的)

2026年12月16日

研究注册日期

首次提交

2026年4月20日

首先提交符合 QC 标准的

2026年6月4日

首次发布 (实际的)

2026年6月10日

研究记录更新

最后更新发布 (实际的)

2026年6月23日

上次提交的符合 QC 标准的更新

2026年6月18日

最后验证

2026年4月1日