PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury
Role and Mechanism of PyroEVs in Regulating Lipid Droplet-Mitochondrial Coupling Via PLIN3 in Sepsis-Induced Vascular Endothelial Cell Injury
Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients.
Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers.
Inclusion Criteria:
- Presence of confirmed or suspected infection;
- Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline;
- Signed informed consent. Exclusion Criteria: Age < 18 or > 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
Primary outcome: 28-day mortality, SOFA score
研究概览
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Fei Peng, Dr. PhD.
- 电话号码：15950565786
- 邮箱：afei0312@163.com
学习地点
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Jiangsu
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Nanjing、Jiangsu、中国、210009
- 招聘中
- Zhongda Hospital, Southeast University
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副研究员：
- Fei Peng, Dr.PhD.
-
接触：
- Fei Fei Peng, PhD. MD.
- 电话号码：15950565786
- 邮箱：afei0312@163.com
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接触：
- Yang
- 邮箱：afei0312@163.com
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首席研究员：
- Yi Yang, Dr.PhD.
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副研究员：
- Zihan Hu, Dr.
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-
参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
① Study Subjects: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers.
② Inclusion Criteria:
- Presence of confirmed or suspected infection;
- Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline;
- Signed informed consent. ③ Exclusion Criteria: Age < 18 or > 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
描述
Inclusion Criteria:
- a. Presence of confirmed or suspected infection; b. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; c. Signed informed consent.
Exclusion Criteria:
- Age < 18 or > 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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败血症
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不干预
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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28天死亡率
大体时间：28天
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28天
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Concentration of pyroptic extracellular vesicles (PyroEVs) in plasma
大体时间：Day 1
|
The concentration of pyroptic extracellular vesicles (PyroEVs) in plasma will be measured using nanoparticle tracking analysis.
Results will be reported as particles per milliliter (particles/mL).
|
Day 1
|
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Concentration of PLIN3 in plasma
大体时间：Day 1
|
Day 1
|
|
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SOFA score
大体时间：28 days
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28 days
|
合作者和调查者
调查人员
- 首席研究员：Yi Yang、Zhongda hospital
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.