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Validity and Reliability of the 2-Minute Step Test in Patients With Lipedema

2026年11月4日更新者：Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Construct Validity and Reliability of the 2-Minute Step Test in Patients With Lipedema: A Cross-Sectional Study

Lipedema is a chronic, progressive adipose tissue disorder that predominantly affects women and is characterized by symmetric, disproportionate subcutaneous fat accumulation in the lower extremities, pain, tenderness, and easy bruising. It is associated with reduced mobility and impaired functional capacity. Although the 2-Minute Step Test (2MST) is a practical, low-cost measure of functional capacity that requires no equipment or large space, its validity and reliability have not been investigated in patients with lipedema. The aim of this study is to evaluate the construct validity and test-retest reliability of the 2MST in women with lipedema.

研究概览

地位

招聘中

条件

脂肪水肿

详细说明

This prospective, cross-sectional study will enroll 55 women diagnosed with lipedema (stage 2 and above) according to the Wold and Halk-Damstra criteria. Participants will undergo the 2-Minute Step Test (2MST), the 6-Minute Walk Test (6MWT), the Timed Up and Go Test (TUGT), the Visual Analog Scale (VAS) for pain, and the Lower Extremity Functional Scale (LEFS). Vital signs (blood pressure, oxygen saturation, heart rate) will be checked before testing. Tests will be administered in a fixed order (2MST, then 6MWT, then TUGT) with at least 30 minutes of rest between them, by the same examiner, at similar times of day. To assess test-retest reliability, the 2MST will be repeated after a 7-day interval by the same examiner. Reliability will be evaluated using the intraclass correlation coefficient (ICC) with 95% confidence intervals, standard error of measurement (SEM), and minimum detectable change (MDC95). Construct validity will be evaluated using Spearman correlation coefficients between the 2MST and the 6MWT, TUGT, LEFS, and VAS.

研究类型

观察性的

注册 (估计的)

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

姓名：Merve Aydın, MD
电话号码：2124445434
邮箱：merveay9702@gmail.com

学习地点

土耳其（türkiye）
- Bahcelievler
  - Istanbul、Bahcelievler、土耳其（türkiye）、34100
    - 招聘中
    - İstanbul Physical Medicine and Rehabilitation Research and Training Hospital
    - 接触：
      
      Merve Aydin, MD

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 65年 (成人、年长者)

接受健康志愿者

不适用

有资格学习的性别

女性

取样方法

非概率样本

研究人群

Patients with lipedema

描述

Inclusion Criteria:

Clinically diagnosed with lipedema according to the Wold and Halk-Damstra criteria, stage 2 and above
Aged 18-65 years, female
No walking-limiting pathology
Willing to participate

Exclusion Criteria:

Uncontrolled hypertension
Decompensated cardiac failure
Systemic, degenerative, neurological, rheumatological, or orthopedic disease affecting lower-extremity function
Lower-extremity surgery within the past 6 months
Peripheral artery disease causing vascular claudication
Severe psychiatric disorder (active psychosis, severe major depression) or cognitive impairment preventing compliance with test instructions
Neuromuscular disease
Pregnancy
Advanced-stage lipo-lymphedema severely restricting ambulation

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

观测模型：CASE_ONLY
时间观点：CROSS_SECTIONAL

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
2-Minute Step Test (2MST) 大体时间：Baseline	Functional exercise capacity assessed by the number of times the participant raises the knee to the required height during 2 minutes. Higher scores indicate better functional exercise capacity.	Baseline

次要结果测量

结果测量	措施说明	大体时间
6-Minute Walk Test (6MWT) 大体时间：Baseline	Functional exercise capacity assessed by the total distance walked in 6 minutes (meters). Greater walking distance indicates better functional capacity and endurance.	Baseline
Timed Up and Go Test (TUGT) 大体时间：Baseline	Functional mobility assessed by the time required to stand up from a chair, walk 3 meters, turn around, walk back, and sit down (seconds). Longer completion times indicate poorer functional mobility and balance.	Baseline
Lower Extremity Functional Scale (LEFS) 大体时间：Baseline	Self-reported lower extremity function assessed using a 20-item questionnaire with a total score ranging from 0 to 80. Higher scores indicate better lower extremity function and less disability.	Baseline
Visual Analog Scale (VAS) 大体时间：Baseline	Pain intensity assessed using a 100-mm visual analog scale ranging from 0 (no pain) to 100 (worst imaginable pain). Higher scores indicate greater pain intensity.	Baseline

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

调查人员

首席研究员：Nurdan Paker, Prof、Istanbul Physical Medicine Rehabilitation Training and Research Hospital

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2026年8月10日

初级完成 (估计的)

2027年4月10日

研究完成 (估计的)

2027年4月10日

研究注册日期

首次提交

2026年8月4日

首先提交符合 QC 标准的

2026年8月4日

首次发布 (实际的)

2026年8月7日

研究记录更新

最后更新发布 (实际的)

2026年11月5日

上次提交的符合 QC 标准的更新

2026年11月4日

最后验证

2026年11月1日