Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
Prospective Comparison of Photon-Counting Detector CT and Conventional Energy-Integrating Detector CT for Carotid Atherosclerotic Plaque Assessment in Patients With Carotid Artery Stenosis
研究概览
地位
详细说明
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of carotid atherosclerotic plaques in patients with carotid artery stenosis.
The study will evaluate differences between the two CT techniques in the visualization and quantitative characterization of carotid plaques, including plaque morphology, plaque burden, plaque components, calcification-related artifacts, and degree of carotid artery stenosis. Objective and subjective image quality will also be compared.
The study is intended to determine whether the improved spatial resolution and spectral imaging capabilities of photon-counting CT provide advantages over conventional CT for the characterization of carotid atherosclerotic disease.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Jinhao Lyu, MD
- 电话号码：+8615903562929
- 邮箱：330322990@qq.com
研究联系人备份
- 姓名：Jinying He
- 邮箱：1527012389@qq.com
学习地点
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Beijing Municipality
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Beijing、Beijing Municipality、中国、100853
- 招聘中
- Chinese PLA General Hospital
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接触：
- Jinhao Lyu, MD
- 电话号码：+8615903562929
- 邮箱：330322990@qq.com
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接触：
- Jinying He
- 电话号码：+8613854153820
- 邮箱：1527012389@qq.com
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Age 18 years or older.
- Patients with carotid atherosclerotic plaque or carotid artery stenosis.
- Patients scheduled to undergo carotid artery stenting.
- Patients undergoing preprocedural carotid CTA examination.
- Ability to provide written informed consent.
Exclusion Criteria:
- Known allergy to iodinated contrast material.
- Severe renal insufficiency or other contraindications to contrast-enhanced CT.
- Pregnancy or suspected pregnancy.
- Severe motion or other artifacts resulting in nondiagnostic image quality.
- Incomplete clinical or imaging data.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Patients With Carotid Artery Stenosis
Patients with carotid artery stenosis who undergo preprocedural carotid CT angiography will be prospectively enrolled.
Carotid plaque characteristics and image quality will be evaluated and compared between photon-counting detector CT angiography and conventional energy-integrating detector CT angiography.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Carotid Plaque Visualization and Characterization on PCD-CTA Compared With Conventional EID-CTA
大体时间：1-4 years
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Carotid atherosclerotic plaques will be independently evaluated on photon-counting detector CTA and conventional energy-integrating detector CTA.
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1-4 years
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Contrast-to-noise ratio on PCD-CTA compared with conventional EID-CTA
大体时间：1-4years
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Contrast-to-noise ratio (CNR) will be quantitatively calculated from measurements obtained on PCD-CTA and conventional EID-CTA using a predefined measurement method.
CNR values will be compared between the two CT techniques.
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1-4years
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合作者和调查者
调查人员
- 学习椅：Xin Lou、Chinese PLA General Hospital
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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