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Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis

19. august 2026 opdateret af: Xin Lou, Chinese PLA General Hospital

Prospective Comparison of Photon-Counting Detector CT and Conventional Energy-Integrating Detector CT for Carotid Atherosclerotic Plaque Assessment in Patients With Carotid Artery Stenosis

This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of carotid atherosclerotic plaques in patients with carotid artery stenosis.

Studieoversigt

Status

Rekruttering

Betingelser

Detaljeret beskrivelse

The study will evaluate differences between the two CT techniques in the visualization and quantitative characterization of carotid plaques, including plaque morphology, plaque burden, plaque components, calcification-related artifacts, and degree of carotid artery stenosis. Objective and subjective image quality will also be compared.

The study is intended to determine whether the improved spatial resolution and spectral imaging capabilities of photon-counting CT provide advantages over conventional CT for the characterization of carotid atherosclerotic disease.

Undersøgelsestype

Observationel

Tilmelding (Anslået)

100

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Navn: Jinhao Lyu, MD
Telefonnummer: +8615903562929
E-mail: 330322990@qq.com

Undersøgelse Kontakt Backup

Navn: Jinying He
E-mail: 1527012389@qq.com

Studiesteder

Kina
- Beijing Municipality
  - Beijing, Beijing Municipality, Kina, 100853
    - Rekruttering
    - Chinese PLA General Hospital
    - Kontakt:
      
      Jinhao Lyu, MD
      
      Telefonnummer: +8615903562929
      
      E-mail: 330322990@qq.com
    - Kontakt:
      
      Jinying He
      
      Telefonnummer: +8613854153820
      
      E-mail: 1527012389@qq.com

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

Barn
Voksen
Ældre voksen

Tager imod sunde frivillige

N/A

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The study population will consist of patients with carotid atherosclerotic stenosis referred for carotid CT angiography. Eligible participants will be prospectively enrolled before carotid artery intervention.

Beskrivelse

Inclusion Criteria:

Age 18 years or older.
Patients with carotid atherosclerotic plaque or carotid artery stenosis.
Patients scheduled to undergo carotid artery stenting.
Patients undergoing preprocedural carotid CTA examination.
Ability to provide written informed consent.

Exclusion Criteria:

Known allergy to iodinated contrast material.
Severe renal insufficiency or other contraindications to contrast-enhanced CT.
Pregnancy or suspected pregnancy.
Severe motion or other artifacts resulting in nondiagnostic image quality.
Incomplete clinical or imaging data.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal grupper/kohorter

Kohorter og interventioner

Gruppe / kohorte
Patients With Carotid Artery Stenosis Patients with carotid artery stenosis who undergo preprocedural carotid CT angiography will be prospectively enrolled. Carotid plaque characteristics and image quality will be evaluated and compared between photon-counting detector CT angiography and conventional energy-integrating detector CT angiography.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Carotid Plaque Visualization and Characterization on PCD-CTA Compared With Conventional EID-CTA Tidsramme: 1-4 years	Carotid atherosclerotic plaques will be independently evaluated on photon-counting detector CTA and conventional energy-integrating detector CTA.	1-4 years

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Contrast-to-noise ratio on PCD-CTA compared with conventional EID-CTA Tidsramme: 1-4years	Contrast-to-noise ratio (CNR) will be quantitatively calculated from measurements obtained on PCD-CTA and conventional EID-CTA using a predefined measurement method. CNR values will be compared between the two CT techniques.	1-4years

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Chinese PLA General Hospital

Efterforskere

Studiestol: Xin Lou, Chinese PLA General Hospital

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

7. januar 2026

Primær færdiggørelse (Anslået)

7. januar 2029

Studieafslutning (Anslået)

7. januar 2029

Datoer for studieregistrering

Først indsendt

8. august 2026

Først indsendt, der opfyldte QC-kriterier