Multicentre Evaluation of Spinal Bone Pathologies Using Zero Echo Time (ZTE) Pseudo-CT MRI Sequences: a Clinical Implementation Study (MULTILUMBAR)
Innovative sequences known as "pseudo-CT"-such as Ultrashort Echo Time (UTE) and Zero Echo Time (ZTE)-enable good visualization of mineralized bone. These new sequences appear to enhance MRI performance in the detection of fractures, spondylolysis, and other bone abnormalities.
We would like to offer patients referred for a CT scan due to lumbar spine bone pathology the option of undergoing an MRI study, in order to compare the performance of the two techniques.
研究概览
详细说明
Magnetic resonance imaging (MRI) is the gold-standard modality for examining the bone marrow and soft tissues of the spine, thanks to its excellent contrast resolution. It enables precise visualization of the intervertebral discs, nerve roots, and spinal cord. However, its ability to visualize bone mineral remains limited due to the rapid decay of the T2 signal and the inability of conventional sequences to capture signals from tissues with very short relaxation times. Consequently, assessing bone structures-such as cortical or trabecular bone, osteophytes, or fractures-remains challenging, particularly in cases of complex pathologies.
Innovative sequences known as "pseudo-CT" sequences-such as Ultrashort Echo Time (UTE) and Zero Echo Time (ZTE)-enable the capture of signals from tissues with very short T2 relaxation times and provide good visualization of mineralized bone. These new sequences appear to enhance MRI performance in the detection of fractures, spondylolysis, and other bone abnormalities.
Despite the promising potential of "pseudo-CT" sequences, studies comparing them to conventional CT and MRI sequences remain limited, as do data regarding their overall clinical benefit. Further research is therefore needed to evaluate their diagnostic value, their ability to improve patient management, and their potential to reduce the need for other imaging examinations.
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Frédéric Emmanuel Lecouvet, MD-PhD
- 电话号码：003227642793
- 邮箱：frederic.lecouvet@saintluc.uclouvain.be
研究联系人备份
- 姓名：Perrine Elizabeth Triqueneaux, Msc
- 电话号码：003227642935
- 邮箱：perrine.triqueneaux@saintluc.uclouvain.be
学习地点
-
-
-
Brussels、比利时、1200
- 招聘中
- Cliniques Universitaires Saint Luc
-
接触：
- Frédéric E Lecouvet, MD-PhD
- 电话号码：003227642793
- 邮箱：frederic.lecouvet@saintluc.ucouvain.be
-
接触：
- Perrine E Triqueneaux, Msc
- 邮箱：perrine.triqueneaux@saintluc.uclouvain.be
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Adults requiring a CT scan as part of their clinical assessment for lumbar spine imaging who also provide informed consent to participate in the study.
- Patients presenting with acute or chronic low back pain and requiring a CT scan for diagnostic purposes.
Exclusion Criteria:
- Contraindications to MRI, such as pacemakers, metal implants, severe claustrophobia, or pregnancy
- Spinal surgery within the last six months.
- Patients who cannot or do not wish to provide informed consent.
学习计划
研究是如何设计的？
设计细节
- 主要用途：诊断
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：All patients
Each patient has a lumbar spine CT scan scheduled as part of their clinical follow-up. We are adding a lumbar spine MRI for the purposes of the study. |
Lumbar spine MRI using innovative sequences known as "pseudo-CT," enabling the capture of signals from tissues with very short T2 relaxation times and providing good visualization of mineralized bone. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
sensitivity and specificity of pseudo-CT MRI
大体时间：One MRI of 30 min
|
To evaluate the sensitivity and specificity of pseudo-CT MRI for the detection of bone lesions. |
One MRI of 30 min
|
合作者和调查者
调查人员
- 首席研究员：Frédéric E Lecouvet, MD-PhD、Cliniques universitaires Saint-Luc- Université Catholique de Louvain
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2025/05MAI/177
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.