Sex Differences in BDNF Study (BDNF-SD)
Investigation of Sex-differences the BDNF Response to Exercise
A single bout of exercise can improve cognitive abilities like memory and attention. These functions help us navigate through everyday life. However, we do not fully understand how exercise improves cognitive abilities. We believe that exercise improves the brain by increasing the amount of BDNF in the blood. BDNF is very important for learning and memory. However, we still do not know if BDNF responds differently to exercise between females and males.
The purpose of this work is to characterize potential sex-differences in the circulating BDNF response to acute exercise. We will test the hypothesis that males will have greater serum and plasma BDNF responses compared to females following a maximal exercise test.
研究概览
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Jeremy J Walsh, PhD
- 电话号码：23523 905-525-9140
- 邮箱：walshj18@mcmaster.ca
学习地点
-
-
Ontario
-
Hamilton、Ontario、加拿大、L8S 4K1
- 招聘中
- McMaster University
-
接触：
- Jeremy J Walsh, PhD
- 电话号码：23523 9055259140
- 邮箱：walshj18@mcmaster.ca
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Between the ages of 18 and 35
Exclusion Criteria:
- presence of type 2 diabetes
- history of hypoglycaemia
- history of concussion(s) with persistent symptoms
- presence of major depressive disorder
- history of cardiovascular events requiring hospitalization (i.e., heart attack, stroke)
- presence of respiratory disease (e.g. asthma)
- pre-existing injuries that prevent aerobic exercise participation.
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：VO2peak Test
Responses will be compared between males and females following a single experimental visit. Participants will complete a incremental ramp test to volitional exhaustion on a cycle ergometer, with venous blood draws characterizing BDNF responses at baseline and during the recovery period up to 1-hour post-exercise. |
Incremental ramp test to volitional exhaustion on a cycle ergometer. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Plasma and Serum BDNF
大体时间：At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
Measured via ELISA analysis of venous samples obtained from a forearm vein |
At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Platelet Count
大体时间：At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
Measured from venous samples obtained from a forearm vein |
At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
|
Blood lactate
大体时间：At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
Measured from venous samples obtained from a forearm vein |
At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
|
Oxygen uptake
大体时间：During incremental ramp test to volitional exhaustion
|
Breath-by-breath analysis performed via metabolic cart |
During incremental ramp test to volitional exhaustion
|
|
Flow-mediated dilation (FMD)
大体时间：At baseline and 15 and 60 minutes post-exercise.
|
Measured via brachial artery ultrasound |
At baseline and 15 and 60 minutes post-exercise.
|
合作者和调查者
调查人员
- 首席研究员：Jeremy J Walsh, PhD、McMaster University
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
IPD 计划说明
The investigators will share individual patient data (de-identified) with researchers upon request
IPD 共享时间框架
Beginning 12 months and ending 36 months following article publication.
IPD 共享访问标准
Anyone who wishes to access the data.
IPD 共享支持信息类型
- 研究方案
- 树液
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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