Sex Differences in BDNF Study (BDNF-SD)
Investigation of Sex-differences the BDNF Response to Exercise
A single bout of exercise can improve cognitive abilities like memory and attention. These functions help us navigate through everyday life. However, we do not fully understand how exercise improves cognitive abilities. We believe that exercise improves the brain by increasing the amount of BDNF in the blood. BDNF is very important for learning and memory. However, we still do not know if BDNF responds differently to exercise between females and males.
The purpose of this work is to characterize potential sex-differences in the circulating BDNF response to acute exercise. We will test the hypothesis that males will have greater serum and plasma BDNF responses compared to females following a maximal exercise test.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Undersøgelsestype
Tilmelding (Anslået)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiekontakt
- Navn: Jeremy J Walsh, PhD
- Telefonnummer: 23523 905-525-9140
- E-mail: walshj18@mcmaster.ca
Studiesteder
-
-
Ontario
-
Hamilton, Ontario, Canada, L8S 4K1
- Rekruttering
- McMaster University
-
Kontakt:
- Jeremy J Walsh, PhD
- Telefonnummer: 23523 9055259140
- E-mail: walshj18@mcmaster.ca
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Between the ages of 18 and 35
Exclusion Criteria:
- presence of type 2 diabetes
- history of hypoglycaemia
- history of concussion(s) with persistent symptoms
- presence of major depressive disorder
- history of cardiovascular events requiring hospitalization (i.e., heart attack, stroke)
- presence of respiratory disease (e.g. asthma)
- pre-existing injuries that prevent aerobic exercise participation.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: VO2peak Test
Responses will be compared between males and females following a single experimental visit. Participants will complete a incremental ramp test to volitional exhaustion on a cycle ergometer, with venous blood draws characterizing BDNF responses at baseline and during the recovery period up to 1-hour post-exercise. |
Incremental ramp test to volitional exhaustion on a cycle ergometer. |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Plasma and Serum BDNF
Tidsramme: At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
Measured via ELISA analysis of venous samples obtained from a forearm vein |
At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Platelet Count
Tidsramme: At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
Measured from venous samples obtained from a forearm vein |
At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
|
Blood lactate
Tidsramme: At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
Measured from venous samples obtained from a forearm vein |
At baseline and 0, 15, 30, 45, and 60 minutes post-exercise.
|
|
Oxygen uptake
Tidsramme: During incremental ramp test to volitional exhaustion
|
Breath-by-breath analysis performed via metabolic cart |
During incremental ramp test to volitional exhaustion
|
|
Flow-mediated dilation (FMD)
Tidsramme: At baseline and 15 and 60 minutes post-exercise.
|
Measured via brachial artery ultrasound |
At baseline and 15 and 60 minutes post-exercise.
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: Jeremy J Walsh, PhD, McMaster University
Datoer for undersøgelser
Studer store datoer
Studiestart (Anslået)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- BDNF-SD
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
IPD-planbeskrivelse
The investigators will share individual patient data (de-identified) with researchers upon request
IPD-delingstidsramme
Beginning 12 months and ending 36 months following article publication.
IPD-delingsadgangskriterier
Anyone who wishes to access the data.
IPD-deling Understøttende informationstype
- STUDY_PROTOCOL
- SAP
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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