Effect of Turmeric Extract With Black Pepper on Tooth Pain After Root Canal Treatment
EFFECT OF PREOPERATIVE ORAL CURCUMIN WITH PIPERINE ON POSTOPERATIVE PAIN FOLLOWING SINGLE-VISIT PRIMARY ROOT CANAL TREATMENT IN MANDIBULAR MOLARS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS
The purpose of this study is to evaluate the effectiveness of taking a turmeric extract supplement before a root canal to help reduce tooth pain after the procedure.
Patients diagnosed with symptomatic irreversible pulpitis (severe, irreversible tooth nerve inflammation causing significant pain) in their lower back teeth (mandibular molars) will participate in the study. All participants will receive a standard, single visit root canal treatment. Before the procedure begins, one group of patients will receive an oral supplement containing curcumin (the active compound in turmeric) combined with piperine (black pepper extract, which helps the body absorb curcumin). Another group will receive a placebo (an inactive substance).
The investigators will compare the levels of postoperative pain between the two groups in the days following the root canal treatment to see if the turmeric extract supplement successfully provides better pain relief.
研究概览
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Zonash Rashid, BDS
- 电话号码：00923208899790
- 邮箱：zonashrashid005@gmail.com
学习地点
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Punjab Province
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Rawalpindi、Punjab Province、巴基斯坦
- Watim Medical & Dental College
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接触：
- Zonash Rashid, BDS
- 电话号码：00923208899790
- 邮箱：zonashrashid005@gmail.com
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接触：
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首席研究员：
- Zonash Rashid, BDS
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Patients aged 18 to 60 years.
- Mature permanent mandibular first or second molar with clinical diagnosis of symptomatic irreversible pulpitis.
- Moderate to severe preoperative pain on the VAS.
- Willingness to provide written informed consent and complete the 48-hour pain record.
Exclusion Criteria:
- Pregnancy or lactation.
- Known hypersensitivity to curcumin, turmeric or capsule components.
- Analgesic or anti-inflammatory medication within 12 hours before treatment.
- Anticoagulant or antiplatelet therapy, clinically relevant bleeding disorder, or significant hepatic, renal or gastrointestinal disease.
- Acute apical abscess, swelling, sinus tract or radiographic apical periodontitis.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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安慰剂比较：安慰剂组
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An inactive capsule manufactured to be completely identical in appearance, color, size, and weight to the active curcumin capsule, administered preoperatively. |
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实验性的：Curcumin Arm
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An oral administration consisting of curcumin paired with piperine, administered preoperatively to enhance bioavailability prior to the root canal treatment. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Postoperative Pain Score
大体时间：24 Hours
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Postoperative pain will be assessed using a 0-100 mm Visual Analog Scale (VAS), where a score of 0 mm represents "no pain" and a score of 100 mm represents "the worst possible pain." Patients will mark their pain level on a 100 mm line, and higher scores indicate a greater intensity of postoperative pain. |
24 Hours
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Rescue Analgesic Consumption
大体时间：Up to 48 hours post-treatment
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The total amount of rescue medication taken by the participants will be recorded. Patients will be instructed to take Ibuprofen as needed for severe postoperative pain. The outcome will be measured as the average number of Ibuprofen tablets consumed per participant during the follow up period. A lower tablet count indicates better pain management by the preoperative intervention. |
Up to 48 hours post-treatment
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合作者和调查者
出版物和有用的链接
一般刊物
- Pak JG, White SN. Pain prevalence and severity before, during, and after root canal treatment: a systematic review. J Endod. 2011 Apr;37(4):429-38. doi: 10.1016/j.joen.2010.12.016.
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. doi: 10.1055/s-2006-957450.
- Lopresti AL, Smith SJ, Hood SD, et al. Efficacy of curcumin plus piperine co-supplementation in pain management: a systematic review and meta-analysis. Front Nutr. 2024;11:1348329.
- Singhal R, Agarwal A, Rastogi P, et al. Current applications of Curcuma longa in dentistry: a scoping review of literature published after 2019. BMC Oral Health. 2026;26(1):45-58.
- Reddy MS, Ramachandra SS, Shetty SR, Khazi SS, Ur Rahman Tippu MS, Narayanan LA, Shetty RM, Azim SA, Ramana VV, Al-Bayati SAAF, Razooki A, Fouad NN. Analgesic Efficacy of Phytotherapeutic Agents in Dental Pain Management: A Systematic Review. Int J Dent. 2025 Nov 20;2025:5614623. doi: 10.1155/ijod/5614623. eCollection 2025.
- Bucevic Popovic V, Karahmet Farhat E, Banjari I, Jelicic Kadic A, Puljak L. Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study. Pharmaceuticals (Basel). 2024 Jan 28;17(2):164. doi: 10.3390/ph17020164.
- Di Cosola M, Cazzolla AP, Charitos IA, et al. The role of curcumin in oral health and diseases: a systematic review. Dent J (Basel). 2024;12(5):132.
- Hashemi N, Shahsavari F, Mokhtari H, et al. Analgesic effect of a kind of herbal medicine, compared to ibuprofen on post-endodontic pain: a randomized clinical trial study. J Mashhad Dent Sch. 2023;47(3):337-345.
- Abdelnaby MS, Eid GEM, El Nabarawi MA. The effect of premedication with curcumin on post-operative pain in single visit endodontic treatment of acute pulpitis in mandibular molars: a randomized controlled trial. J Dent Oral Epidemiol. 2021;1(3):1-11.
- Khan MK, Khan IA, Liaquat A. Therapeutic Potential of Curcumin with and without Strengthening Exercises in Improving Rheumatoid Arthritis. J Coll Physicians Surg Pak. 2022 Dec;32(12):1640-1643. doi: 10.29271/jcpsp.2022.12.1640.
- Singla R, Gupta C, Gill GS, Jain N, Arora S, Algarni YA, Kader MA, Cicciu M, Minervini G. Effect of Curcuma longa (Turmeric), as an intra-canal medicament, on inter-appointment endodontic pain in patients with symptomatic irreversible pulpitis: A randomized controlled clinical trial. Heliyon. 2024 Jun 28;10(14):e33797. doi: 10.1016/j.heliyon.2024.e33797. eCollection 2024 Jul 30.
- Basu P, Maier C, Basu A. Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review. Int J Mol Sci. 2021 Apr 28;22(9):4666. doi: 10.3390/ijms22094666.
- De Geus JL, Wambier LM, Boing TF, Loguercio AD, Reis A. Effects of Ibuprofen Compared to Other Premedication Drugs on the Risk and Intensity of Postendodontic Pain: A Systematic Review. Eur Endod J. 2018 Oct 9;3(3):123-133. doi: 10.14744/eej.2018.83803. eCollection 2018.
- Elkhadem A, Ezzat K, Ramadan M, AbdelGhaffar S, Khamis D, Hassan A, Abdel-Mawgoud A, Mamdouh A, AbouZeid M, Amin S. The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single-centre randomized controlled trial. Int Endod J. 2018 Apr;51 Suppl 3:e189-e196. doi: 10.1111/iej.12795. Epub 2017 Jul 4.
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- WM&DCR/R&D(IERB)/2026/273
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
IPD 计划说明
he individual participant data will not be shared outside the host institution to maintain patient confidentiality and comply with institutional privacy protocols.
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研究美国 FDA 监管的设备产品
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