Osteoarthritis: Weakness From Inflammation

May 28, 2009 updated by: National Institute on Aging (NIA)

Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Study Overview

Status

Completed

Conditions

Detailed Description

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Study Type

Observational

Enrollment (Anticipated)

88

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Maryland
      • Baltimore, Maryland, United States, 21225
        • Harbor Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

50 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Community - Men and women

Description

Inclusion Criteria:

  • 50 years of age or older
  • Normal body weight (a Body Mass Index (BMI) of 30 or less)
  • Osteoarthritis of the knee (prior to knee surgery)
  • Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria:

  • History of a stroke
  • History of muscle weakness or paralysis
  • History of Rheumatoid Arthritis or
  • Inflammatory Joint Disease
  • History of a Bleeding Disorder
  • History of Gout
  • Diabetes for which you take insulin
  • Polymyalgia rheumatica (total body muscle aching/stiffness)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
1
Participants with symptomatic knee osteoarthritis
2
Participants without symptomatic knee osteoarthritis, age-matched as controls

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Institute on Aging (NIA)

Investigators

  • Principal Investigator: Shari Ling, MD, NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2001

Primary Completion (Actual)

May 1, 2009

Study Completion (Actual)

May 1, 2009

Study Registration Dates

First Submitted

February 24, 2005

First Submitted That Met QC Criteria

February 24, 2005

First Posted (Estimate)

February 25, 2005

Study Record Updates

Last Update Posted (Estimate)

May 29, 2009

Last Update Submitted That Met QC Criteria

May 28, 2009

Last Verified

May 1, 2009

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AG0016

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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