Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)

May 25, 2010 updated by: Johns Hopkins University

Coronary Atherosclerosis Evaluation by Arterial Wall MRI

The overall goal of this study is to use MRI to:

Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Procedure: MR Imaging of the Coronary Arteries

Detailed Description

Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes

Study Type

Interventional

Enrollment (Actual)

179

Phase

Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

United States
- Illinois
  - Chicago, Illinois, United States, 60611
    - Northwestern University MESA Field Center
- Maryland
  - Baltimore, Maryland, United States, 21244
    - Johns Hopkins MESA Field Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

45 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Description

Inclusion Criteria:

Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
Male or Female adult equal to or older than 45 years of age
Willing/able to provide informed consent

Exclusion Criteria:

Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
Metal in the eyes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Interventional Model: Single Group Assignment
Masking: None (Open Label)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mean Coronary Wall Thickness Time Frame: n/a (cross sectional analysis)	Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).	n/a (cross sectional analysis)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Johns Hopkins University

Collaborators

Northwestern University

Investigators

Principal Investigator: David A Bluemke, MD PhD, Johns Hopkins University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Multi-Ethnic Study of Atherosclerosis webpage

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2005

Primary Completion (Actual)

June 1, 2008

Study Completion (Actual)

June 1, 2008

Study Registration Dates

First Submitted

July 18, 2006

First Submitted That Met QC Criteria