- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00507663
Elder Surgery - Functional Recovery Following Beta Blockade
This study proposes a prospective randomized study of elders undergoing elective major abdominal surgery to assess recovery following a unique anesthetic regimen incorporating a adrenergic receptor antagonist. The purposes of this study are to:
- to determine if using atenolol, a beta-blocker drug commonly used to treat high blood pressure and heart disease, as part of your anesthetic regimen will decrease complications that sometimes occur in elderly patients who are undergoing surgery and being given anesthesia.
- to see if it improves or quickens your recovery from anesthesia and surgery.
- to help investigators design better ways to administer anesthesia during surgery, especially in elderly patients, so that the complications and the time to recover from surgery and anesthesia can be decreased.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Increasing numbers of aged patients with multiple chronic diseases are undergoing major surgery. In the first third the last century, surgery was considered a desperate measure and patients greater than 50 years of age were felt incapable of sustaining the rigors of an inguinal hernia repair. Advances in anesthesia during the last century have allowed surgeons to develop an extraordinary array of procedures with excellent outcomes. Over 5.5 million patients aged 60 and over had major procedures in 1994. Centenarians routinely undergo surgical procedures.
Notwithstanding the enthusiasm for surgical treatments, morbidity, mortality, and recovery times for elderly patients are still substantially greater than for younger patients. Some morbidities, such as postoperative delirium and cognitive dysfunction appear to predominantly affect elderly patients. In a previous study, Dr. Valerie Lawrence, a co-investigator on this proposal, demonstrated that recovery from major surgery, as measured by the ability to accomplish standard activities of daily living, takes an average of 6 weeks while more complicated instrumental activities of daily living take an average of 3 months to return to baseline in elderly surgical patients. These data have profound implications for initiatives to control length of hospital stay, utilization of resources and costs of care. Evidence suggests that family members are requiring extra time off work to care for family members discharged earlier from hospitals.
Published reports and our preliminary data support the notion that intraoperative administration of adrenergic receptor antagonists (blockers) will improve functional recovery following surgery under general anesthesia. There is value in targeting functional status for elders undergoing surgery, because there is a direct relationship between functional status and utilization of health resources. Maximizing postoperative recovery, as opposed to minimizing morbidity and mortality, associated with surgical interventions in the elderly is consistent with the goal of prolonging "active life expectancy" expounded by Healthy People 2002.
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
Minnesota
-
Rochester, Minnesota, United States, 55905
- The Mayo Clinic
-
-
New York
-
New York, New York, United States, 10029
- Icahn School of Medicine at Mount Sinai
-
New York, New York, United States, 10016
- NYU School of Medicine
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients 65 years of age or older
- Patients undergoing elective major abdominal surgery (including but not limited to bowel, gastric, esophageal, pancreatic, gynecologic, urologic, and major intra-abdominal vascular procedures).
- Procedures requiring general anesthesia
- Laparoscopic-assisted major abdominal procedures
- Procedures requiring a 2-3 day postoperative stay will be included.
Exclusion Criteria:
- Unable to give informed consent to participate
- Folstein Mini-Mental State Examination Score < 17
- Gastrostomy tube placement
- Laparoscopic cholecystectomy, laparoscopic Nissen fundoplication, or any type of Hernia repair
- Appendectomy
- Emergency surgery
- Contraindications to adrenergic antagonists (third-degree heart block, decompensated congestive heart failure, active bronchospasm)
- Surgery within the previous month
- Major systemic infections
- Allergies to or incompatibilities with any drug used in this study
- Principle language other than English or Spanish
- Residence greater than 100 miles away from Manhattan
- Chronic debilitated state from which significant functional improvement following surgery is not anticipated (e.g., some nursing home residents, known metastatic cancer with poor prognosis)
- Chronic opioid usage
- Immunosuppression (subsequent opportunistic infections may obscure postoperative recovery).
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Atenolol
Atenolol given prior to and for up to 7 days after surgery
|
Patients with a standing prescription for β-blockers will be continued on that medication.
Pts not currently receiving a beta blocker will be given 50mg of atenolol on the morning of surgery, 50-100mg, twice per day, on the first postoperative day until postoperative day 7.
Other Names:
|
No Intervention: routine care
routine clinical care
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Long Term Functional Recovery
Time Frame: at 3 weeks after surgery
|
self reported Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL).
|
at 3 weeks after surgery
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Timed Up and Go test
Time Frame: preoperatively
|
assesses basic functional mobility
|
preoperatively
|
Timed Up and Go test
Time Frame: once at 7-10 days postoperatively
|
assesses basic functional mobility
|
once at 7-10 days postoperatively
|
Timed Up and Go test
Time Frame: 1 month postoperatively
|
assesses basic functional mobility
|
1 month postoperatively
|
Timed Up and Go test
Time Frame: 3 months postoperatively
|
assesses basic functional mobility
|
3 months postoperatively
|
Timed Up and Go test
Time Frame: 6 months postoperatively
|
assesses basic functional mobility
|
6 months postoperatively
|
Hand grip strength
Time Frame: preoperatively
|
performance-based measure of upper extremity strength.
|
preoperatively
|
Hand grip strength
Time Frame: once at 7-10 days postoperatively
|
performance-based measure of upper extremity strength.
|
once at 7-10 days postoperatively
|
Hand grip strength
Time Frame: 1 month postoperatively
|
performance-based measure of upper extremity strength.
|
1 month postoperatively
|
Hand grip strength
Time Frame: 3 months postoperatively
|
performance-based measure of upper extremity strength.
|
3 months postoperatively
|
Hand grip strength
Time Frame: 6 months postoperatively
|
performance-based measure of upper extremity strength.
|
6 months postoperatively
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Jefrey H. Silverstein, MD, Icahn School of Medicine at Mount Sinai
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Mental Disorders
- Pathologic Processes
- Postoperative Complications
- Neurocognitive Disorders
- Cognition Disorders
- Cognitive Dysfunction
- Postoperative Cognitive Complications
- Physiological Effects of Drugs
- Adrenergic beta-Antagonists
- Adrenergic Antagonists
- Adrenergic Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Autonomic Agents
- Peripheral Nervous System Agents
- Sympatholytics
- Adrenergic beta-1 Receptor Antagonists
- Atenolol
Other Study ID Numbers
- GCO 00-0100
- AG018772 (Other Grant/Funding Number: National Institute on Aging (NIA))
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Post Operative Cognitive Dysfunction
-
Attikon HospitalCompleted
-
Xijing HospitalFirst Affiliated Hospital Xi'an Jiaotong University; Shanghai 10th People's... and other collaboratorsTerminatedPost Operative Cognitive DysfunctionChina
-
HealthPartners InstituteCompletedPost Operative Cognitive DysfunctionUnited States
-
Burcu Ozalp HorsanaliCompletedPost Operative Cognitive Dysfunction
-
Assistance Publique - Hôpitaux de ParisMinistry of Health, FranceCompleted
-
Massachusetts General HospitalCompletedPost Operative Cognitive Dysfunction | Emergence From AnesthesiaUnited States
-
University of PadovaMaran EleonoraUnknownEmergence Delirium | Post-Operative Cognitive Dysfunction
-
University of PadovaRecruitingEmergence Delirium | Post-Operative Cognitive DysfunctionItaly
-
Charite University, Berlin, GermanyTerminatedDelirium and Post-operative Cognitive Dysfunction (POCD)Germany
-
Albert Einstein College of MedicineNational Institute on Aging (NIA)CompletedPost-operative Delirium | Post-operative Cognitive DeclineUnited States
Clinical Trials on Atenolol
-
Vanderbilt UniversityNational Heart, Lung, and Blood Institute (NHLBI); National Center for Research...Completed
-
Seoul National University HospitalCompleted
-
Shanghai Jiao Tong University School of MedicineRecruiting
-
SandozCompletedHypertension | Angina
-
Brigham and Women's HospitalUniversity of UtahWithdrawnHypertensionUnited States
-
Saini FoundationMedtronic - MITGUnknown
-
National Taiwan University HospitalUnknown
-
Sundeep Khosla, M.D.Columbia University; University of California, San Francisco; MaineHealthActive, not recruiting
-
Ranbaxy Laboratories LimitedCompleted