Training-induced Cerebral Reorganization in Schizophrenia

April 12, 2010 updated by: University of Konstanz
The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease.

In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing.

The other training involves a variability of cognitive abilities.

Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Study Type

Interventional

Enrollment (Anticipated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Germany
    • Baden Württenberg
      • Konstanz, Baden Württenberg, Germany, 78457
        • University of Konstanz

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

No older than 60 years (Child, Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Clinical diagnosis of schizophrenia and disorders with psychotic features
  • Intact hearing abilities

Exclusion Criteria:

  • Mental retardation
  • Age over 60
  • Insufficient German language knowledge

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: BFT
20 schizophrenic patients
Behavioral: Brain Fitness Program
Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention
Active Comparator: CP
19 schizophrenic patients
Behavioral: Cogpack
Computer-aided cognitive program for cognitive abilities
No Intervention: HCG
20 healthy age and sex matched subjects

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Event related potential MEG, test scores in word fluency and verbal learning tasks
Time Frame: pre and post intervention
pre and post intervention

Secondary Outcome Measures

Outcome Measure
Time Frame
Symptom severity, GAF score
Time Frame: pre and post intervention
pre and post intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Konstanz

Collaborators

German Research Foundation

Investigators

  • Study Chair: Brigitte Rockstroh, Prof. Dr., University of Konstanz, Department of Psychology

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2008

Primary Completion (Actual)

June 1, 2009

Study Completion (Actual)

January 1, 2010

Study Registration Dates

First Submitted

June 9, 2008

First Submitted That Met QC Criteria

June 9, 2008

First Posted (Estimate)

June 12, 2008

Study Record Updates

Last Update Posted (Estimate)

April 13, 2010

Last Update Submitted That Met QC Criteria

April 12, 2010

Last Verified

June 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RO 805/14

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Subscribe