- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00712517
Propofol Versus Volatile Anesthesia in Post Operative Pain Management
July 18, 2016 updated by: The Cleveland Clinic
Do Patients Anesthetized With Propofol Have Less Pain Than Those Anesthetized With Volatile?
The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups.
Group 1 patients will receive propofol anesthesia.
Group 2 patients will receive sevoflurane anesthesia.
Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals.
Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump.
VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours.
Piritramid dosage and vomiting will be recorded through the first postoperative morning.
Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning
Study Type
Interventional
Enrollment (Actual)
90
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Vienna, Austria
- Olga Plattner , MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Participants will undergo a stripping operation for varicose veins
- Surgery will be performed by one physician only
- Written informed consent
Exclusion Criteria:
- Any contraindications to the proposed interventions
- Procedures done under regional anesthesia
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: 1
Patients will receive propofol anesthesia during varicose vein stripping surgery.
|
propofol anesthesia 3-5mg/kg
Other Names:
|
Active Comparator: 2
Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.
|
sevoflurane anesthesia
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.
Time Frame: first post operative morning
|
first post operative morning
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To determine the average pain score for each group during the first four hours of recovery after surgery.
Time Frame: 30 minute intervals for first 4 hours post operatively
|
30 minute intervals for first 4 hours post operatively
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Olga Plattner, MD, Medical University of Vienna
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2010
Primary Completion (Actual)
May 1, 2014
Study Completion (Actual)
May 1, 2014
Study Registration Dates
First Submitted
July 7, 2008
First Submitted That Met QC Criteria
July 9, 2008
First Posted (Estimate)
July 10, 2008
Study Record Updates
Last Update Posted (Estimate)
July 20, 2016
Last Update Submitted That Met QC Criteria
July 18, 2016
Last Verified
July 1, 2016
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Cardiovascular Diseases
- Vascular Diseases
- Postoperative Complications
- Pain
- Neurologic Manifestations
- Pain, Postoperative
- Varicose Veins
- Physiological Effects of Drugs
- Central Nervous System Depressants
- Anesthetics, Intravenous
- Anesthetics, General
- Anesthetics
- Platelet Aggregation Inhibitors
- Hypnotics and Sedatives
- Anesthetics, Inhalation
- Propofol
- Sevoflurane
Other Study ID Numbers
- 42908
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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