Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension

Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension.

The investigators propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Study Overview

• Status: Completed
• Conditions: Pulmonary Hypertension
• Intervention / Treatment: Other: No Intervention

Detailed Description

Pulmonary hypertension (PH) is an insidious disorder that can occur in isolation or as a result of various other pulmonary and systemic conditions. If left untreated PH may progress to right heart failure and death. Numerous tests are suggestive but not diagnostic of PH including cardiac echo, pulmonary function testing and chest x-ray. Definitive diagnosis requires right heart catheterization that is invasive, costly and time consuming. The fractal dimension (FD) is an index of the space-filling properties of an object so that the closer the dimension is to the topological dimension in which the object is embedded, the greater the space filling properties. No investigations have been performed to analyze the fractal dimension of pulmonary arteries in patients with PH. We propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

• Study Type: Observational
• Enrollment (Actual): 6

Contacts and Locations

Study Locations

• United States
  • Ohio
    • Columbus, Ohio, United States, 43210
      • The Ohio State University Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients having a right heart catheterization and CT pulmonary angiogram

Description

Inclusion Criteria:

• Patients having a right heart catheterization and CT pulmonary angiogram

Exclusion Criteria:

• None

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Pulmonary Hypertension; Patients having a right heart catheterization and CT pulmonary angiogram with a diagnosis of Pulmonary Hypertension	Other: No Intervention; This study does not include an intervention but is observational in nature.
Non Pulmonary Hypertension; Patients having a right heart catheterization and CT pulmonary angiogram without a diagnosis of Pulmonary Hypertension.	Other: No Intervention; This study does not include an intervention but is observational in nature.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
FD of the pulmonary artery in patients with PH will be lower when compared to patients without PH.	24 Months

Secondary Outcome Measures

Outcome Measure	Time Frame
FD will correlate with the degree of PH as quantified by the MPAP obtained during RHC.	24 Months
FD will correlate with the functional capacity of the PH patients as quantified by distance during six-minute walk and NYHA functional class.	24 Months

Collaborators and Investigators

• Sponsor: Ohio State University
• Investigators: Principal Investigator: Karen Wood, M.D., Ohio State University

Study record dates

Study Major Dates

• Study Start: April 1, 2010
• Primary Completion (Actual): February 1, 2012
• Study Completion (Actual): February 1, 2012

Study Registration Dates

• First Submitted: May 20, 2010
• First Submitted That Met QC Criteria: June 2, 2010
• First Posted (Estimate): June 3, 2010

Study Record Updates

• Last Update Posted (Estimate): November 1, 2012
• Last Update Submitted That Met QC Criteria: October 31, 2012
• Last Verified: October 1, 2012

More Information

Terms related to this study

• Keywords: Pulmonary Hypertension; Fractal dimension
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Respiratory Tract Diseases; Lung Diseases; Hypertension; Hypertension, Pulmonary
• Other Study ID Numbers: 2010H0097